Patent US5709877A successfully refreshed from Google Patents.
US5709877A
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Gels in the form of highly hydrated self-supporting film, the process for their preparation, and their use in the therapy of cutaneous lesions and/or pathologies
Assignee: Fidia SpA
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Filing: 1995-06-07
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Granted: 1998-01-20
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Expires: 2015-06-07
Abstract
Abstract This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
Inventors
- 👤 Francesco Della Valle
- 👤 Alessandro Rastrelli
- 👤 Gabriella Calderini
- 👤 Aurelio Romeo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; C; C08; C08L; C08L5/00; C08L5/08; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/28; A61L15/42; A61L15/44; C08L5/04; A61L2300/00; Y; Y10; Y10S; Y10S424/00; Y10S424/13
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
94 words
A hydrated self-supporting gel film for use as wound medication or covering material to be applied in direct contact with the area to be treated in the therapeutic treatment of cutaneous lesions and/or cutaneous pathologies, consisting essentially of a quantity of between 1% and 7.5% of at least one alkaline alginate, between 0.1% and 5% of alkaline earth alginate, between 0.1% and 10% of a polyhydric alcohol and between 0.05% and 10% of a polymer of hydrophilic character selected from the group consisting of hyaluronic acid and derivatives thereof, the remaining constituent being water.
Claim 2
Dependent Claim
94 words
A hydrated self-supporting gel film for use as wound medication or covering material to be applied in direct contact with the area to be treated in the therapeutic treatment of cutaneous lesions and/or cutaneous pathologies, consisting essentially of a quantity of between 1% and 7.5% of at least one alkaline alginate, between 0.1% and 5% of alkaline earth alginate, between 0.1% and 10% of a polyhydric alcohol and between 0.05% and 10% of a polymer of hydrophilic character selected from the group consisting of hyaluronic acid and derivatives thereof, the remaining constituent being water.
Claim 3
Dependent Claim
16 words
The gel film as claimed in claim 1 containing 3.5% of at least one alkaline alginate.
Claim 4
Dependent Claim
27 words
The gel film as claimed in claim 1 in which the alkaline alginate is selected from the group consisting of sodium alginate, potassium alginate and ammonium alginate.
Claim 5
Dependent Claim
14 words
The gel film as claimed in claim 1 which comprises 1% of calcium alginate.
Claim 6
Dependent Claim
15 words
The gel film as claimed in claim 1 which comprises 5% of a polyhydric alcohol.
Claim 7
Dependent Claim
15 words
The gel film as claimed in claim 1 in which the polyhydric alcohol is glycerol.
Claim 8
Dependent Claim
15 words
The gel film as claimed in claim 1 which comprises 0.5% of the hydrophilic polymer.
Claim 9
Dependent Claim
16 words
The gel film as claimed in claim 1 in which the hydrophilic polymer is sodium hyaluronate.
Claim 10
Dependent Claim
21 words
The gel film as claimed in claim 1, in which the hydrophilic polymer is hyaluronic acid 75% esterified with ethyl alcohol.
Claim 11
Dependent Claim
25 words
The gel film as claimed in claim 1, in which the hydrophilic polymer is the neomycin salt of hyaluronic acid 75% esterified with ethyl alcohol.
Claim 12
Dependent Claim
40 words
The gel film as claimed in claim 1, in which the hydrophilic polymer is a mixed total ester of hyaluronic acid, 80% of the carboxy groups being esterified with ethanol and 20% of the carboxy groups being esterified with hydrocortisone.
Claim 13
Dependent Claim
32 words
A therapeutic method for treating cutaneous lesions and/or cutaneous pathologies which comprises the application in direct contact to the area to be treated of a hydrated self-supporting gel film of claim 1.
Claim 14
Dependent Claim
18 words
The method according to claim 12, wherein the gel film comprises 3.5% of at least one alkaline alginate.
Claim 15
Dependent Claim
15 words
The method according to claim 12 wherein the gel film comprises 1% of calcium alginate.
Claim 16
Dependent Claim
15 words
The method according to claim 12 wherein the gel film comprises 5% of polyhydric alcohol.
Claim 17
Dependent Claim
12 words
The method according to claim 12 wherein the polyhydric alcohol is glycerol.
Claim 18
Dependent Claim
17 words
The method according to claim 12 wherein the gel film further comprises 0.5% of the hydrophilic polymer.
Claim 19
Dependent Claim
14 words
The method according to claim 12, wherein the gel film further comprises a medicament.
Claim 20
Dependent Claim
21 words
The method according to claim 18, wherein the medicament is selected from the group consisting of antiseptic, antibiotic and anti-inflammatory drugs.
Claim 21
Dependent Claim
16 words
The method as claimed in claim 18, wherein the medicament quantity is between 0.01% and 10%.
Claim 22
Dependent Claim
36 words
The method according to claim 12 wherein the gel film comprises a mixed total ester of hyaluronic acid, 80% of the carboxy groups being esterified with ethanol and 20% of the carboxy groups esterified with hydrocortisone.
Claim 23
Dependent Claim
19 words
The method according to claim 12 wherein the polymer of hydrophilic character is hyaluronic acid esterified with ethyl alcohol.
Claim 24
Dependent Claim
13 words
The method according to claim 22 wherein the degree of esterification is 75%.
Claim 25
Dependent Claim
23 words
The method as claimed in claim 12, wherein the hydrophilic polymer is the neomycin salt of hyaluronic acid 75% esterified with ethyl alcohol.
Claim 26
Dependent Claim
25 words
The method as claimed in claim 12, wherein the alkaline alginate is selected from the group consisting of sodium alginate, potassium alginate and ammonium alginate.
Claim 27
Dependent Claim
14 words
The method as claimed in claim 12, wherein the hydrophilic polymer is sodium hyaluronate.
Claim 28
Dependent Claim
101 words
A hydrated self-supporting gel film for use as wound medication or covering material to be applied in direct contact with the area to be treated in the therapeutic treatment of cutaneous lesions and/or cutaneous pathologies, consisting essentially of a quantity of between 1% and 7.5% of at least one alkaline alginate, between 0.1% and 5% of alkaline earth alginate, between 0.1% and 10% of a polyhydric alcohol, between 0.05% and 10% of a polymer of hydrophilic character selected from the group consisting of hyaluronic acid and derivatives thereof, and between 0.01% and 10% of a medicament, the remaining constituent being water.
Claim 29
Dependent Claim
101 words
A hydrated self-supporting gel film for use as wound medication or covering material to be applied in direct contact with the area to be treated in the therapeutic treatment of cutaneous lesions and/or cutaneous pathologies, consisting essentially of a quantity of between 1% and 7.5% of at least one alkaline alginate, between 0.1% and 5% of alkaline earth alginate, between 0.1% and 10% of a polyhydric alcohol, between 0.05% and 10% of a polymer of hydrophilic character selected from the group consisting of hyaluronic acid and derivatives thereof, and between 0.01% and 10% of a medicament, the remaining constituent being water.
Claim 30
Dependent Claim
16 words
The gel film as claimed in claim 27 containing 3.5% of at least one alkaline alginate.
Claim 31
Dependent Claim
27 words
The gel film as claimed in claim 27 in which the alkaline alginate is selected from the group consisting of sodium alginate, potassium alginate and ammonium alginate.
Claim 32
Dependent Claim
14 words
The gel film as claimed in claim 27 which comprises 1% of calcium alginate.
Claim 33
Dependent Claim
15 words
The gel film as claimed in claim 27 which comprises 5% of a polyhydric alcohol.
Claim 34
Dependent Claim
15 words
The gel film as claimed in claim 27 in which the polyhydric alcohol is glycerol.
Claim 35
Dependent Claim
15 words
The gel film as claimed in claim 27 which comprises 0.5% of the hydrophilic polymer.
Claim 36
Dependent Claim
16 words
The gel film as claimed in claim 27 in which the hydrophilic polymer is sodium hyaluronate.
Claim 37
Dependent Claim
23 words
The gel film as claimed in claim 27, wherein the medicament is selected from the group consisting of antiseptic, antibiotic and anti-inflammatory drugs.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-19 | 2001-07-21 | 2002-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-19 | 2005-07-21 | 2006-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-19 | 2009-07-21 | 2010-01-20 | $7700.00 | Window Closed / Lapsed |