US5670558A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical instruments that exhibit surface lubricity when wetted
Assignee: Terumo Corp
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Filing: 1995-07-06
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Granted: 1997-09-23
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Expires: 2015-07-06
Abstract
Abstract This invention provides a medical instrument having on a surface a layer (surface lubricating layer) that forms a hydrogel when wetted and that is composed of an insolubilized water-soluble or water-swellable polymer having a reactive functional group in the molecule. The surface having outstanding surface lubricity and, optionally, the ability to prevent the formation of thrombi.
Inventors
- 👤 Makoto Onishi
- 👤 Kenichi Shimura
- 👤 Naoki Ishii
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:32
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/1027; A61L; A61L27/00; A61L27/28; A61L27/34; A61L29/00; A61L29/08; A61L29/085; A61L29/14; A61L29/145; A61L31/00; A61L31/08; A61L31/10; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L2400/00; A61L2400/10; A61M25/0043; A61M25/0045; A61M2025/0046; A61M2025/1043; A61M2025/1088
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A medical instrument exhibiting surface lubricity when wetted, comprising a surface coated with a surface lubricating layer, said surface lubricating layer comprising a block or graft copolymer having a hydrophilic domain and a reactive domain, said reactive domain having a reactive functional group selected from the group consisting of epoxy and isocyanate, and wherein said functional group is cross-linked with another functional group.
Claim 2
Dependent Claim
63 words
A medical instrument exhibiting surface lubricity when wetted, comprising a surface coated with a surface lubricating layer, said surface lubricating layer comprising a block or graft copolymer having a hydrophilic domain and a reactive domain, said reactive domain having a reactive functional group selected from the group consisting of epoxy and isocyanate, and wherein said functional group is cross-linked with another functional group.
Claim 3
Dependent Claim
40 words
A medical instrument according to claim 1, wherein said surface lubricating layer further comprises a polymer having a functional group selected from the group consisting of a carboxyl group, an amino group, a hydroxyl group, and a maleic anhydride group.
Claim 4
Dependent Claim
98 words
A medical instrument exhibiting surface lubricity when wetted, comprising a matrix material surfaced with a surface lubricating layer comprising a block or graft copolymer having a hydrophilic domain and a reactive domain, said reactive domain having a reactive functional group selected from the group consisting of an epoxy group and an isocyanate group, wherein said surface lubricating layer is formed by dipping the matrix material in a solution of said block or graft copolymer; and wherein said functional group is cross-linked with another functional group to form an interpenetrating network structure between the matrix material and the copolymer.
Claim 5
Dependent Claim
98 words
A medical instrument exhibiting surface lubricity when wetted, comprising a matrix material surfaced with a surface lubricating layer comprising a block or graft copolymer having a hydrophilic domain and a reactive domain, said reactive domain having a reactive functional group selected from the group consisting of an epoxy group and an isocyanate group, wherein said surface lubricating layer is formed by dipping the matrix material in a solution of said block or graft copolymer; and wherein said functional group is cross-linked with another functional group to form an interpenetrating network structure between the matrix material and the copolymer.
Claim 6
Dependent Claim
17 words
A medical instrument according to claim 1, wherein said surface lubricating layer further comprises an antithrombotic agent.
Claim 7
Dependent Claim
21 words
A medical instrument according to claim 1, wherein the molar ratio of said hydrophilic domains to said reactive domains is 1:50.
Claim 8
Dependent Claim
37 words
A medical instrument according to claim 1, wherein said surface lubricating layer is formed by coating said block or graft copolymer on the surface of the medical instrument; and heating said coating to at least 40° C.
Claim 9
Dependent Claim
59 words
A medical instrument according to claim 3, wherein the swelled ratio of the matrix surface is within the range of 1 to 100% as defined by equation (1): ##EQU5## wherein W o =the weight of the matrix material before dipping the matrix material into the solution; and ΔW=the increased weight of the matrix material after dipping into the solution.
References Cited (Backward Citations)
US4119094A
Cited
US4100309A
Cited
GB2064556A
Cited
US4373009A
Cited
US4459317A
Cited
US4487808A
Cited
US4666437A
Cited
JPS60241448A
Cited
EP0166998B1
Cited
US4876126A
Cited
GB2190387A
Cited
EP0389632A1
Cited
US5079093A
Cited
US5091205A
Cited
US5135516A
Cited
WO1993011751A1
Cited
JPH067426A
Cited
EP0611576A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-22 | 2001-03-24 | 2001-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-22 | 2005-03-24 | 2005-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-22 | 2009-03-24 | 2009-09-23 | $7700.00 | Window Closed / Lapsed |