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US5653744A
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Device and method for vascular anastomosis
Assignee: Khouri Biomedical Res Inc
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Filing: 1995-04-27
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Granted: 1997-08-05
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Expires: 2015-04-27
Abstract
Abstract A temporary stent and method for vascular anastomosis are disclosed. The method comprises placing, in a vessel to be anastomosed, a stent comprising a biocompatible material; applying staples to anastomose the vessel; and converting the stent material into a liquid that is miscible with blood by melting with warmed saline or pulsed radiation. Also disclosed is a method and composition for delivery of a drug that prevents thrombus formation and/or intimal hyperplasia at the anastomosis.
Inventors
- 👤 Roger K. Khouri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:35
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/11; A61B17/064; A61B17/08; A61B17/083; A61F; A61F2/00; A61F2/82; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
72 words
A method for vascular anastomosis in a subject comprising the steps of: (a) first, placing, in a vessel to be anastomosed, a stent comprising a biocompatible material; (b) second, applying staples to evert the edges of the vessel by pressing the staples against the vessel edges to thereby use the stent as an anvil to anastomose the vessel; and (c) third, converting the stent into a liquid that is miscible with blood.
Claim 2
Independent Claim
72 words
A method for vascular anastomosis in a subject comprising the steps of: (a) first, placing, in a vessel to be anastomosed, a stent comprising a biocompatible material; (b) second, applying staples to evert the edges of the vessel by pressing the staples against the vessel edges to thereby use the stent as an anvil to anastomose the vessel; and (c) third, converting the stent into a liquid that is miscible with blood.
Claim 3
Dependent Claim
33 words
The method according to claim 1 wherein the stent comprises a material which melts upon applying heat and the step of converting the stent to a liquid includes the step of applying heat.
Claim 4
Dependent Claim
23 words
The method according to claim 2 wherein the step of applying heat includes the step of irrigating the anastomosed vessel with warmed saline.
Claim 5
Dependent Claim
34 words
The method according to claim 3 wherein the stent comprises a material selected from the group consisting of a mixture of monoglycerides, diglycerides and triglycerides; a polyglycolic acid; a polyethylene glycol; and mixtures thereof.
Claim 6
Dependent Claim
14 words
The method according to claim 4 wherein the stent material comprises WITEPSOL® H 37.
Claim 7
Dependent Claim
35 words
The method according to claim 1 wherein the stent comprises a material which melts on applying pulsed radiation and the step of converting the stent to a liquid includes the step of applying pulsed radiation.
Claim 8
Dependent Claim
34 words
The method according to claim 6 wherein the stent comprises a material selected from the group consisting of a mixture of monoglycerides, diglycerides and triglycerides; a polyglycolic acid; a polyethylene glycol; and mixtures thereof.
Claim 9
Dependent Claim
33 words
The method according to claim 1 wherein the anastomosis is an end-to-end anastomosis and the stent has a center and two opposite ends, and a lengthwise tapering from the center to each end.
Claim 10
Dependent Claim
25 words
The method according to claim 1 wherein the anastomosis is an end-to-side anastomosis and the stent is in an L-shape, a T-shape or a Y-shape.
Claim 11
Dependent Claim
19 words
The method according to claim 1 wherein the stent contains a substance that prevents thrombus formation or intimal hyperplasia.
Claim 12
Dependent Claim
22 words
The method according to claim 10 wherein the substance that prevents thrombus formation or intimal hyperplasia comprises Tissue Factor Pathway Inhibitor (TFPI).
Claim 13
Independent Claim
77 words
A method for vascular anastomosis in a subject comprising the steps of: (a) first, everting the vessel edges by advancing a stent comprising a biocompatible material into the vessel to be anastomosed; (b) second, applying staples to the everted edges of the vessel by pressing the staples against the vessel edges to thereby use the stent as an anvil to anastomose the vessel; and (c) third, converting the stent into a liquid that is miscible with blood.
Claim 14
Independent Claim
77 words
A method for vascular anastomosis in a subject comprising the steps of: (a) first, everting the vessel edges by advancing a stent comprising a biocompatible material into the vessel to be anastomosed; (b) second, applying staples to the everted edges of the vessel by pressing the staples against the vessel edges to thereby use the stent as an anvil to anastomose the vessel; and (c) third, converting the stent into a liquid that is miscible with blood.
Claim 15
Dependent Claim
23 words
The method according to claim 12 wherein the stent has a portion with a cross-sectional area sized to fit snugly within said vessel.
Claim 16
Dependent Claim
33 words
The method according to claim 13 wherein the stent has a center and two opposite ends, and a lengthwise tapering from the center to each end, said center comprising said snugly fitting portion.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-04 | 2001-02-03 | 2001-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-04 | 2005-02-03 | 2005-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-04 | 2009-02-03 | 2009-08-05 | $7700.00 | Window Closed / Lapsed |