US5531735A
Expired / Lapsed
US
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Medical devices containing triggerable disintegration agents
Assignee: Boston Scientific Scimed Inc
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Filing: 1994-09-27
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Granted: 1996-07-02
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Expires: 2014-09-27
Abstract
Abstract The invention discloses temporary medical devices such as stent implants which can be disintegrated in-vivo upon demand by release of an agent held trapped within the device. The device is fabricated from a matrix polymer material which is essentially insoluble in body fluids and a disintegration agent which acts to initiate decomposition of the matrix polymer when contacted therewith. The disintegration agent is trapped within and chemically isolated from the matrix polymer such as by encapsulation, and is releasable within the matrix polymer upon contact of the device with a releasing agent which liberates the encapsulated disintegration agent.
Inventors
- 👤 Samuel A. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61L29/00; A61L29/14; A61L29/148; A61L31/00; A61L31/14; A61L31/148; A61F; A61F2210/00; A61F2210/0004
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
99 words
A composition suitable for use in the fabrication of medical devices comprising: a) a matrix polymer which is essentially insoluble in body fluids and; b) a disintegration agent which acts to decompose said matrix polymer when contacted therewith, said disintegration agent being contained within and chemically isolated from said matrix polymer by encapsulation in an ionically crosslinked second polymer or by presence in an interpolyelectrolyte complex, wherein said disintegration agent is selected from the group consisting of enzymes, acids, bases and electrolytes, and wherein said interpolyelectrolyte complex is a complex of the disintegration agent with an oppositely charged partner.
Claim 2
Dependent Claim
99 words
A composition suitable for use in the fabrication of medical devices comprising: a) a matrix polymer which is essentially insoluble in body fluids and; b) a disintegration agent which acts to decompose said matrix polymer when contacted therewith, said disintegration agent being contained within and chemically isolated from said matrix polymer by encapsulation in an ionically crosslinked second polymer or by presence in an interpolyelectrolyte complex, wherein said disintegration agent is selected from the group consisting of enzymes, acids, bases and electrolytes, and wherein said interpolyelectrolyte complex is a complex of the disintegration agent with an oppositely charged partner.
Claim 3
Dependent Claim
24 words
The composition of claim 1 wherein said disintegration agent is chemically isolated from said matrix polymer by encapsulation in an ionically crosslinked second polymer.
Claim 4
Dependent Claim
21 words
The composition of claim 2 wherein said disintegration agent is selected from the group consisting of enzymes, acids, bases and electrolytes.
Claim 5
Dependent Claim
13 words
The composition of claim 2 wherein said matrix polymer is crosslinked ionic polymer.
Claim 6
Dependent Claim
46 words
The composition of claim 4 wherein said matrix polymer comprises an ionically crosslinked anionic polymer selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 7
Dependent Claim
37 words
The composition of claim 5 wherein said matrix polymer is an ionically crosslinked anionic polymer comprising at least one polymer selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, and salts thereof.
Claim 8
Dependent Claim
12 words
The composition of claim 4 wherein said matrix polymer is a polysaccharide.
Claim 9
Dependent Claim
29 words
The composition of claim 4 wherein said matrix polymer comprises an ionically crosslinked cationic polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 10
Dependent Claim
17 words
The composition of claim 2 wherein said ionically crosslinked second polymer contains carboxylic, sulfate or amine functionality.
Claim 11
Dependent Claim
28 words
The composition of claim 9 wherein said ionically crosslinked second polymer is selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, chitosan and salts thereof.
Claim 12
Dependent Claim
23 words
The composition of claim 2 wherein said ionically crosslinked second polymer is selected from the group consisting of calcium alginate and calcium pectinate.
Claim 13
Dependent Claim
28 words
The composition of claim 2 wherein said matrix polymer is selected from the group consisting of chitosan, alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid and their salts.
Claim 14
Dependent Claim
12 words
The composition of claim 2 wherein said disintegration agent is an enzyme.
Claim 15
Dependent Claim
38 words
The composition of claim 1 wherein said disintegration agent is chemically isolated from said matrix polymer by presence in an interpolyelectrolyte complex, wherein said interpolyelectrolyte complex is a complex of the disintegration agent with an oppositely charged partner.
Claim 16
Dependent Claim
10 words
A shaped medical device having the composition of claim 2.
Claim 17
Dependent Claim
10 words
A shaped medical device having the composition of claim 14.
Claim 18
Dependent Claim
35 words
A process for the in vivo decomposition of the device of claim 15 comprising contacting said device in vivo with a releasing agent capable of displacing crosslinking ions present in said ionically crosslinked second polymer.
Claim 19
Dependent Claim
33 words
A process for the in vivo decomposition of the device of claim 16 comprising contacting said device in vivo with a releasing agent capable of displacing crosslinking ions present in said interpolyelectrolyte complex.
Claim 20
Dependent Claim
21 words
The process of claim 17 wherein said disintegration agent is selected from the group consisting of enzymes, acids, bases and electrolytes.
Claim 21
Dependent Claim
44 words
The process of claim 17 wherein said releasing agent is selected from the group consisting of ethylene diamine tetraacetic acid, ethylene diamine tetraacetate, citrate, organic phosphates, inorganic phosphates, trisodium carboxymethyloxysuccinate, nitrilotriacetic acid, maleic acid, oxalate, polyacrylic acid, and sodium, potassium, calcium and magnesium ions.
Claim 22
Dependent Claim
14 words
The process of claim 17 wherein said matrix polymer is a crosslinked ionic polymer.
Claim 23
Dependent Claim
12 words
The process of claim 21 wherein said matrix polymer is a polysaccharide.
Claim 24
Dependent Claim
28 words
The process of claim 17 wherein said ionically crosslinked second polymer is selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, chitosan and salts thereof.
Claim 25
Dependent Claim
23 words
The process of claim 17 wherein said ionically crosslinked second polymer is selected from the group consisting of calcium alginate and calcium pectinate.
Claim 26
Dependent Claim
15 words
The process of claim 24 wherein said releasing agent is a source of phosphate ions.
Claim 27
Dependent Claim
28 words
The process of claim 17 wherein said matrix polymer is selected from the group consisting of chitosan, alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid and their salts.
Claim 28
Dependent Claim
21 words
The process of claim 18 wherein said releasing agent is an electrolyte capable of displacing ions present in said interpolyelectrolyte complex.
Claim 29
Dependent Claim
17 words
The composition of claim 14 wherein the disintegration agent comprises an enzyme with an overall cationic charge.
Claim 30
Dependent Claim
15 words
The composition of claim 14 wherein said matrix polymer comprises an ionically crosslinked ionic polymer.
Claim 31
Dependent Claim
37 words
The composition of claim 29 wherein said matrix polymer is an ionically crosslinked anionic polymer comprising at least one polymer selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, and salts thereof.
Claim 32
Dependent Claim
14 words
The composition of claim 29 wherein said matrix polymer is an ionically crosslinked polysaccharide.
Claim 33
Dependent Claim
29 words
The composition of claim 29 wherein the matrix polymer is an ionically crosslinked cationic polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 34
Dependent Claim
29 words
The medical device of claim 15 wherein the medical device is a shaped medical device selected from the group consisting of stents, catheter components, cannula components, plugs and constrictors.
Claim 35
Dependent Claim
29 words
The medical device of claim 16 wherein the medical device is a shaped medical device selected from the group consisting of stents, catheter components, cannula components, plugs and constrictors.
Claim 36
Dependent Claim
15 words
The process of claim 18 wherein the releasing agent is a source of phosphate ions.
Claim 37
Dependent Claim
41 words
The process of claim 17 wherein the releasing agent is contacted with the medical device in vivo by means of introduction through the diet, parenteral feeding, insertion of a catheter which injects the agent within the device, or through an enema.
Claim 38
Dependent Claim
41 words
The process of claim 18 wherein the releasing agent is contacted with the medical device in vivo by means of introduction through the diet, parenteral feeding, insertion of a catheter which injects the agent within the device, or through an enema.
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