US5480644A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of injectable biomaterials for the repair and augmentation of the anal sphincters
Assignee: JSF Consultants Ltd
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Filing: 1992-02-28
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Granted: 1996-01-02
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Expires: 2012-02-28
Abstract
Abstract This invention discloses methods of repairing structurally defective or inadequately functioning muscles of the anal sphincter and methods of improving the competency of incompetent anal sphincters by administering an effective amount of an injectable biomaterial into the defect or into the anal sinuses. Preferred biomaterials to be used in this invention are collagen formulations.
Inventors
- 👤 Jeffrey S. Freed
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:49
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61F; A61F2/00; A61F2/0004; A61P; A61P1/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
57 words
A method of improving the competency of incompetent anal sphincters comprising (1) selecting an injectable biomaterial capable of persisting at a site of its injection for at least three months, and (2) injecting an effective amount of the injectable material into the anal sinuses between the blood vessels, sufficient to improve competency of the incompetent anal sphincter.
Claim 2
Independent Claim
57 words
A method of improving the competency of incompetent anal sphincters comprising (1) selecting an injectable biomaterial capable of persisting at a site of its injection for at least three months, and (2) injecting an effective amount of the injectable material into the anal sinuses between the blood vessels, sufficient to improve competency of the incompetent anal sphincter.
Claim 3
Dependent Claim
16 words
The method of claim 1, wherein said injectable biomaterial comprises atelopeptide fibrillar, crosslinked or non-crosslinked collagen.
Claim 4
Dependent Claim
48 words
The method of claim 1, wherein said injectable biomaterial is an aqueous suspension of a material selected from the group consisting of atelopeptide fibrillar, crosslinked collagen, non-crosslinked collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, hydrogen beads, silicon carbide beads and glass beads, with a biocompatible fluid lubricant.
Claim 5
Dependent Claim
41 words
The method of claim 3 wherein said biocompatible fluid lubricant is selected from the group consisting of: hyaluronic acid, dextran sulfate, dextran, succinylated non-crosslinked collagen, methylated non-crosslinked collagen, glycogen, glycerol, dextrose, maltose, triglycerides of fatty acids, egg yolk phospholipids, and heparin.
Claim 6
Dependent Claim
14 words
The method of claim 1, wherein said injectable biomaterial is a second nucleation collagen.
Claim 7
Dependent Claim
15 words
The method of claim 2 wherein said collagen is conjugated to a chemically activated polymer.
Claim 8
Dependent Claim
13 words
The method of claim 6 wherein said chemically activated polymer is polyethylene glycol.
Claim 9
Dependent Claim
15 words
The method of claim 2 wherein said collagen is crosslinked with a bifunctional activated polymer.
Claim 10
Dependent Claim
16 words
The method of claim 8 wherein said collagen and said bifunctional activated polymer crosslink in situ.
Claim 11
Dependent Claim
13 words
The method of claim 8 wherein said bifunctional activated polymer is polyethylene glycol.
Claim 12
Dependent Claim
15 words
The method of claim 2 wherein said biomaterial further comprises a ceramic and/or mineral material.
Claim 13
Dependent Claim
20 words
The method of claim 11 wherein said ceramic material comprises ceramic particles in the size range of about 50-250 microns.
Claim 14
Dependent Claim
15 words
The method of claim 1 wherein said biomaterial further comprises an antimicrobial additive and/or antibiotic.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-01-01 | 1999-07-03 | 2000-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-01-01 | 2003-07-03 | 2004-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-01-01 | 2007-07-03 | 2008-01-02 | $7700.00 | Window Closed / Lapsed |