US5470831A
Expired / Lapsed
US
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Angiogenic peptides
Assignee: Cytomedix Inc
•
Filing: 1993-03-24
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Granted: 1995-11-28
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Expires: 2013-03-24
Abstract
Abstract The present invention relates to peptides and peptide derivatives related to platelet factor 4 which exhibit angiogenic activity, to pharmaceutical compositions comprising said peptides, and to methods for promoting angiogenesis utilizing said peptides. It is based, in part, on the discovery that an octapeptide derived from platelet factor 4 and seven structurally related peptides (depicted in FIG. 1) are capable of inducing an angiogenic response in vivo as measured by neovascularization in rabbit corneal implant assay and by measurement of capillary endothelial cell chemoattraction. The angiogenic peptides of the invention may be particularly useful in promoting wound healing, including incisional healing, bone repair, burn healing, and post-infarction repair in myocardial injury, and in facilitating the assimilation of grafted tissues, particularly in persons suffering from vascular insufficiency, such as diabetic patients.
Inventors
- 👤 Russell B. Whitman
- 👤 Robert Wohl
- 👤 Ronald G. Duff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:55
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K38/07; C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/101; A61P; A61P43/00; C07K14/00; C07K14/435; C07K14/52
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg.
Claim 2
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg.
Claim 3
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 1 in a pharmacologically suitable carrier.
Claim 4
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Val-Lys-Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg.
Claim 5
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Val-Lys-Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg.
Claim 6
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 3 in a pharmacologically suitable carrier.
Claim 7
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Ser-Gln-Val-Arg-Pro-Arg.
Claim 8
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Ser-Gln-Val-Arg-Pro-Arg.
Claim 9
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 5 in a pharmacologically suitable carrier.
Claim 10
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Val-Arg-Pro-Arg.
Claim 11
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Val-Arg-Pro-Arg.
Claim 12
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 7 in a pharmacologically suitable carrier.
Claim 13
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-His-Ile-Thr.
Claim 14
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-His-Ile-Thr.
Claim 15
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 9 in a pharmacologically suitable carrier.
Claim 16
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gln-Val.
Claim 17
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gln-Val.
Claim 18
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 11 in a pharmacologically suitable carrier.
Claim 19
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Ser-Gln-Val-Arg.
Claim 20
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Ser-Gln-Val-Arg.
Claim 21
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 13 in a pharmacologically suitable carrier.
Claim 22
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gly-Ile-His-Pro-Lys.
Claim 23
Dependent Claim
10 words
An angiogenic peptide consisting of the amino acid sequence Thr-Thr-Ser-Gly-Ile-His-Pro-Lys.
Claim 24
Dependent Claim
14 words
A pharmaceutical composition comprising the peptide of claim 15 in a pharmacologically suitable carrier.
References Cited (Backward Citations)
US4645828A
Cited
EP0378364A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-11-27 | 1999-05-29 | 1999-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-11-27 | 2003-05-29 | 2003-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-11-27 | 2007-05-29 | 2007-11-28 | $7700.00 | Window Closed / Lapsed |