US4645828A
Expired / Lapsed
US
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Platelet related growth regulator
Assignee: Oncogen LP
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Filing: 1985-03-15
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Granted: 1987-02-24
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Expires: 2005-03-15
Abstract
Abstract Novel polypeptide compositions are provided which inhibit human tumor cell growth, which may or may not stimulate autophosphorylation of pp60 src and induce the release of a 52 kDal polypeptide from neoplastic cells. Individual polypeptides may be isolated from mammalian blood platelets by selected extraction and purification procedures, may be synthesized or produced by hybrid DNA technology.
Inventors
- 👤 Daniel R. Twardzik
- 👤 George J. Todaro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:00
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/521; C07K14/522; A; A61; A61P; A61P35/00; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12; Y10S930/14; Y10S930/26
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
72 words
A composition comprising a compound having the following amino acid sequence: ##STR18## wherein: aa* is V, L or I; aa 45 is V, L, I, K or R; aa 47 is N, O, S or T; aa 55 is V, L, I, N or Q; aa 57 is G, A, K or R; and aa 70 is G, A, S or T, or a fragment of at least 15 amino acids thereof.
Claim 2
Dependent Claim
72 words
A composition comprising a compound having the following amino acid sequence: ##STR18## wherein: aa* is V, L or I; aa 45 is V, L, I, K or R; aa 47 is N, O, S or T; aa 55 is V, L, I, N or Q; aa 57 is G, A, K or R; and aa 70 is G, A, S or T, or a fragment of at least 15 amino acids thereof.
Claim 3
Dependent Claim
16 words
The composition of claim 1, wherein said compound contains at least the 8-amino acid sequence Lys-Lys-Ile-Ile-Lys-Lys-Leu-Leu.
Claim 4
Dependent Claim
27 words
The composition of claim 1, wherein said compound has the following amino acid sequence: Gin-Leu-Ile-Ala-Thr-Leu-Lys- Asp-Gly-Arg-Lys-Ile-Cys-Leu-Asp-Leu-Gln-Ala-Pro-Leu-Tyr-Lys- Lys-Ile-Ile-Lys-Lys-Leu-Leu-Glu-Ser or a fragment of at least 2 amino acids thereof.
Claim 5
Dependent Claim
11 words
The composition of claim 3, wherein said compound has said sequence.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-23 | 1990-08-25 | 1991-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-23 | 1994-08-25 | 1995-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-23 | 1998-08-25 | 1999-02-24 | $7700.00 | Window Closed / Lapsed |