Patent US5461124A successfully refreshed from Google Patents.
US5461124A
Expired / Lapsed
US
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Reactive systems and/or polymer composition for tissue contact with the living body
Assignee: Henkel AG and Co KGaA
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Filing: 1994-03-30
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Granted: 1995-10-24
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Expires: 2014-03-30
Abstract
Abstract Described is the use of physiologically compatible tocopherols and especially of vitamin E as an inhibitor against premature polymerization initiation in reactive systems capable of undergoing a free radical-initiated polymerization, which systems before and/or after the polymerization thereof are placed in tissue contact with the living human or animal body and, more specifically, are implanted into the living organism thereby. The reactive systems and the polymers formed therefrom may be degradation resistant. However, a special embodiment relates to compositions or molded bodies which are decomposed by the living organism, and especially so under time-controlled conditions. The invention further relates to surgical binder systems which are suitable for adhesion bonding endogenous body tissue and which have been based on an adhesive component capable of being activated by free radicals, said adhesive component being present in admixture with a free radical inhibitor and being characterized in that the inhibitor or at least the predominant portion of the inhibitor is vitamin E. It is preferred that the described compositions are free from physiologically unacceptable solvents or residual amounts of solvents left from the preparation process.
Inventors
- 👤 Wolfgang Ritter
- 👤 Hans-Dieter Sitz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:21
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61L24/0015; A61L24/04; A61L24/06; A61L2300/00; A61L2300/40; A61L2300/428
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
47 words
A surgical adhesive or cement free from physiologically unacceptable solvents for the adhesion-bonding of endogenous hard tissue or implants in a human or other animal body comprising A) one or more polymerizable monofunctional or polyfunctional olefinically unsaturated compounds; and B) a polymerization inhibiting quantity of Vitamin E.
Claim 2
Dependent Claim
47 words
A surgical adhesive or cement free from physiologically unacceptable solvents for the adhesion-bonding of endogenous hard tissue or implants in a human or other animal body comprising A) one or more polymerizable monofunctional or polyfunctional olefinically unsaturated compounds; and B) a polymerization inhibiting quantity of Vitamin E.
Claim 3
Dependent Claim
24 words
The surgical adhesive or cement of claim 1 wherein the polymerization inhibiting quantity of Vitamin E is from about 200 to about 10,000 ppm.
Claim 4
Dependent Claim
22 words
The surgical adhesive or cement of claim 2 wherein said quantity of Vitamin E is from about 300 to about 4,000 ppm.
Claim 5
Dependent Claim
25 words
The surgical adhesive or cement of claim 1 wherein said polymerizable monofunctional or polyfunctional olefinically unsaturated compounds are multifunctional or polyfunctional (meth)acrylates or combinations thereof.
Claim 6
Dependent Claim
50 words
The surgical adhesive or cement of claim 1 wherein the adhesive or cement is a two-component system wherein the first component is a monomer resin component containing the one or more polymerizable monofunctional or polyfunctional olefinically unsaturated compounds and the Vitamin E, and the second component is an initiator component.
Claim 7
Dependent Claim
40 words
The surgical adhesive or cement of claim 1 wherein the polymerizable monofunctional or polyfunctional olefinically unsaturated compounds are (meth)acrylic acid esters containing from 2 to 4 (meth)acrylate ester groups on a polyesteroligomer chain formed from at least one hydroxycarboxylic acid.
Claim 8
Dependent Claim
30 words
The surgical adhesive or cement of claim 6 wherein said polyester-oligomer chain is a hydroxyl-terminated oligomer chain produced by the reaction of hydroxycarboxylic acids, polyfunctional alcohols, and polyfunctional carboxylic acids.
Claim 9
Dependent Claim
29 words
The surgical adhesive or cement of claim 7 wherein two (meth)acrylate ester groups are present, one on each terminal hydroxy group at each end of the polyester oligomer chain.
Claim 10
Dependent Claim
25 words
The surgical adhesive or cement of claim 6 wherein the at least one hydroxycarboxylic acid is glycolic acid, lactic acid, hydroxybutyric acid, or combinations thereof.
Claim 11
Dependent Claim
27 words
The surgical adhesive or cement of claim 7 wherein said hydroxycarboxylic acid is lactic acid or glycolic acid and said polyfunctional alcohol is ethylene glycol or glycerol.
Claim 12
Dependent Claim
26 words
The surgical adhesive or cement of claim 6 wherein the (meth)acrylic acid esters have a number average molecular weight of from about 200 to about 600.
Claim 13
Dependent Claim
21 words
The surgical adhesive or cement of claim 11 wherein said number average molecular weight is from about 300 to about 500.
Claim 14
Dependent Claim
27 words
The surgical adhesive or cement of claim 6 wherein the (meth)acrylic acid esters have a viscosity of from about 500 to about 70,000 mPa's at room temperature.
Claim 15
Dependent Claim
19 words
The surgical adhesive or cement of claim 13 wherein said viscosity is from about 3,000 to about 50,000 mPa's.
Claim 16
Dependent Claim
83 words
A two-component surgical adhesive composition free from physiologically unacceptable solvents for the adhesion-bonding of endogenous hard tissue in a human or other animal body, wherein the adhesive when cured is resorbable by the body, consisting essentially of A) a monomer resin component comprising a) at least one (meth)acrylic acid ester containing from 2 to 4 (meth)acrylate ester groups on a polyesteroligomer chain formed from at least one hydroxycarboxylic acid, and b) a polymerization inhibiting quantity of Vitamin E; and B) an initiator component.
Claim 17
Dependent Claim
83 words
A two-component surgical adhesive composition free from physiologically unacceptable solvents for the adhesion-bonding of endogenous hard tissue in a human or other animal body, wherein the adhesive when cured is resorbable by the body, consisting essentially of A) a monomer resin component comprising a) at least one (meth)acrylic acid ester containing from 2 to 4 (meth)acrylate ester groups on a polyesteroligomer chain formed from at least one hydroxycarboxylic acid, and b) a polymerization inhibiting quantity of Vitamin E; and B) an initiator component.
Claim 18
Dependent Claim
50 words
The surgical adhesive composition of claim 15 wherein said polyester-oligomer chain is a hydroxyl-terminated oligomer chain produced by the reaction of hydroxycarboxylic acids, polyfunctional alcohols, and polyfunctional carboxylic acids, and wherein two (meth)acrylate ester groups are present, one on each terminal hydroxy group at each end of the polyesteroligomer chain.
Claim 19
Dependent Claim
25 words
The surgical adhesive of claim 16 wherein said hydroxycarboxylic acid is lactic acid or glycolic acid and said polyfunctional alcohol is ethylene glycol or glycerol.
Claim 20
Dependent Claim
24 words
The surgical adhesive of claim 16 wherein the (meth)acrylic acid esters have a number average molecular weight of from about 300 to about 500.
Claim 21
Dependent Claim
25 words
The surgical adhesive of claim 15 wherein the methacrylic acid esters have a viscosity of from about 500 to about 70,000 mPa's at room temperature.
Claim 22
Dependent Claim
17 words
The surgical adhesive of claim 19 wherein said viscosity is from about 3,000 to about 50,000 mPa's.
References Cited (Backward Citations)
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