Patent US5460939A successfully refreshed from Google Patents.
US5460939A
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Temporary living skin replacement
Assignee: Advanced BioHealing Inc
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Filing: 1994-02-18
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Granted: 1995-10-24
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Expires: 2014-02-18
Abstract
Abstract The present invention relates to a living skin replacement. In particular, it relates to a biosynthetic dressing material composed of a living stromal tissue prepared from stromal cells such as fibroblasts cultured upon a three-dimensional framework and a transitional covering which acts as an epidermal replacement. Such a living skin replacement provides long-term biologic coverage of full-thickness wound defects. Since human fibroblasts are known to be relatively non-antigenic when transferred to allogeneic hosts, a temporary living skin replacement made up of such cells attached to a transitional covering may replace the use of cadaveric skin allografts for achieving temporary wound closure in cases where the patients lack enough healthy skin for autografts.
Inventors
- 👤 John F. Hansbrough
- 👤 Gail K. Naughton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:33
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/06; C12N5/0697; C12N5/0698; A; A61; A61B; A61B90/00; A61K; A61K35/00; A61K35/12; A61K35/28; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/38; A61L27/50; A61L27/60; A61B10/00; A61B10/02; A61B10/0233; A61B10/025; A61B2010/0258; A61K2035/124; C12N2500/00; C12N2500/30; C12N2500/34; C12N2501/00; C12N2501/10; C12N2501/11; C12N2501/30; C12N2501/33; C12N2501/335; C12N2501/38; C12N2501/39; C12N2502/00; C12N2502/08; C12N2502/09; C12N2502/094; C12N2502/11; C12N2502/13; C12N2502/1323; C12N2503/00; C12N2503/04; C12N2510/00; C12N2533/00; C12N2533/30; C12N2533/40; C12N2533/70
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
69 words
A temporary living skin replacement comprising a living stormal tissue substantially enveloping a framework which is prepared in vitro and a transitional covering bonded to the living stromal tissue, which stromal tissue comprises stromal cells and connective tissue proteins naturally secreted by the stromal cells and which framework is composed of a biocompatible, non-living material formed into a three dimensional structure having interstitial spaces bridged by said stromal cells.
Claim 2
Dependent Claim
69 words
A temporary living skin replacement comprising a living stormal tissue substantially enveloping a framework which is prepared in vitro and a transitional covering bonded to the living stromal tissue, which stromal tissue comprises stromal cells and connective tissue proteins naturally secreted by the stromal cells and which framework is composed of a biocompatible, non-living material formed into a three dimensional structure having interstitial spaces bridged by said stromal cells.
Claim 3
Dependent Claim
15 words
The temporary living skin replacement of claim 1 in which the stromal cells are fibroblasts.
Claim 4
Dependent Claim
30 words
The temporary living skin replacement of claim 1 in which the stromal cells are a combination of fibroblasts, endothelial cells, pericytes, macrophages, monocytes, leukocytes, plasma cells, mast cells and adipocytes.
Claim 5
Dependent Claim
18 words
The temporary living skin replacement of claim 1 in which the framework is composed of a biodegradable material.
Claim 6
Dependent Claim
28 words
The temporary living skin replacement of claim 4 in which the biodegradable material is polyglactic acid, chitin, chitosan, cotton, polyglycolic acid, cat gut structures, cellulose, gelatin or dextran.
Claim 7
Dependent Claim
18 words
The temporary living skin replacement of claim 1 in which the framework is composed of a non-biodegradable material.
Claim 8
Dependent Claim
33 words
The temporary living skin replacement of claim 6 in which the non-biodegradable material is a polyamide, a polyester, a polystyrene, a polypropylene, a polyacrylate, a polyvinyl, a polycarbonate, a polytetrafluorethylene or nitrocellulose compound.
Claim 9
Dependent Claim
20 words
The temporary living skin replacement of claim 4, 5, 6 or 7 in which the framework is pre-coated with collagen.
Claim 10
Dependent Claim
15 words
The temporary living skin replacement of claim 8 in which the framework is a mesh.
Claim 11
Dependent Claim
22 words
The temporary living skin replacement of claims 1, 2, 3, 4, 5, 6 or 7 in which the framework is a mesh.
Claim 12
Dependent Claim
17 words
The temporary living skin replacement of claim 1 in which the transitional covering is made of silicone.
Claim 13
Dependent Claim
17 words
The temporary living skin replacement of claim 1 in which the transitional covering is made of polyurethane.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-23 | 1999-04-24 | 1999-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-23 | 2003-04-24 | 2003-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-23 | 2007-04-24 | 2007-10-24 | $7700.00 | Window Closed / Lapsed |