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US5457092A
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Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone
Assignee: Helmholtz Centre for Infection Research
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Filing: 1993-09-13
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Granted: 1995-10-10
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Expires: 2013-09-13
Abstract
Abstract pPTH, bPTH or hPTH is modified by deletions from the natural C- and/or N-terminus. The modified compounds are useful active ingredients in therapeutic compositions. The therapeutic compositions do not stimulate renal adenylate cyclase but, rather, effect chondrocyte proliferation, that is to say, they exhibit a mitogenic and bone-specific effect.
Inventors
- 👤 Klaus-Dieter Schluter
- 👤 Hubert Mayer
- 👤 Edgar Wingender
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:23
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/635; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
55 words
A method of promoting bone growth in a mammal, which comprises: administering systemically to the mammal an effective amount for mitogenesis, of a parathyroid hormone selected from the group consisting of: pPTH, bPTH and hPTH, each modified by deletion of the N-terminus and the C-terminus thereof and each comprising amino acid residues +28 to +34.
Claim 2
Independent Claim
55 words
A method of promoting bone growth in a mammal, which comprises: administering systemically to the mammal an effective amount for mitogenesis, of a parathyroid hormone selected from the group consisting of: pPTH, bPTH and hPTH, each modified by deletion of the N-terminus and the C-terminus thereof and each comprising amino acid residues +28 to +34.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the hormone selected is one of bPTH and hPTH.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the hormone selected comprises amino acid residues +20 to +48.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the hormone selected is bPTH comprising amino acid residues +3 to +34.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein the hormone selected is hPTH comprising amino acid residues +28 to +48.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-09 | 1999-04-10 | 1999-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-09 | 2003-04-10 | 2003-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-09 | 2007-04-10 | 2007-10-10 | $7700.00 | Window Closed / Lapsed |