Patent US5455039A successfully refreshed from Google Patents.
US5455039A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extraluminal regulation of the growth and repair of tubular structures in vivo
Assignee: Harvard University
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Filing: 1994-04-08
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Granted: 1995-10-03
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Expires: 2014-04-08
Abstract
Abstract A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
Inventors
- 👤 Elazer R. Edelman
- 👤 David H. Adams
- 👤 Morris J. Karnovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:18
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K9/0024; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
148 words
A method of regulating repair of a patient's blood vessel wall following surgical anastomosis at a location along said blood vessel, said method comprising, administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate of less than 100 mg/day and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 2
Independent Claim
148 words
A method of regulating repair of a patient's blood vessel wall following surgical anastomosis at a location along said blood vessel, said method comprising, administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate of less than 100 mg/day and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said heparin is non-anticoagulant heparin.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said heparin is anticoagulant heparin.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said blood vessel is an artery.
Claim 6
Independent Claim
136 words
A method of regulating repair of tissue at a location in a patient's blood vessel wall comprising administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 7
Independent Claim
136 words
A method of regulating repair of tissue at a location in a patient's blood vessel wall comprising administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 8
Dependent Claim
11 words
The method of claim 5 wherein said heparin is non-anticoagulant heparin.
Claim 9
Dependent Claim
11 words
The method of claim 5 wherein said heparin is anticoagulant heparin.
Claim 10
Dependent Claim
12 words
The method of claim 5 wherein said blood vessel is an artery.
Claim 11
Dependent Claim
19 words
The method of claim 8 wherein said biocompatible polymer based heparin releasing system comprises an aqueous gel or foam.
Claim 12
Dependent Claim
21 words
The method of claim 5 comprising treating said tissue to promote healing after surgical repair of said vessel at said location.
References Cited (Backward Citations)
US3797485A
Cited
US3993071A
Cited
US4391797A
Cited
US4495174A
Cited
US4808402A
Cited
US4898732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-02 | 1999-04-03 | 1999-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-02 | 2003-04-03 | 2003-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-02 | 2007-04-03 | 2007-10-03 | $7700.00 | Window Closed / Lapsed |