US5455039A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extraluminal regulation of the growth and repair of tubular structures in vivo
Assignee: Harvard University
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Filing: 1994-04-08
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Granted: 1995-10-03
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Expires: 2014-04-08
Abstract
Abstract A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
Inventors
- 👤 Elazer R. Edelman
- 👤 David H. Adams
- 👤 Morris J. Karnovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:54
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K9/0024; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
148 words
A method of regulating repair of a patient's blood vessel wall following surgical anastomosis at a location along said blood vessel, said method comprising, administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate of less than 100 mg/day and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 2
Independent Claim
148 words
A method of regulating repair of a patient's blood vessel wall following surgical anastomosis at a location along said blood vessel, said method comprising, administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate of less than 100 mg/day and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said heparin is non-anticoagulant heparin.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said heparin is anticoagulant heparin.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said blood vessel is an artery.
Claim 6
Independent Claim
136 words
A method of regulating repair of tissue at a location in a patient's blood vessel wall comprising administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 7
Independent Claim
136 words
A method of regulating repair of tissue at a location in a patient's blood vessel wall comprising administering outside said blood vessel at said location, a biocompatible polymer based heparin releasing system, said biocompatible polymer based heparin releasing system releasing said heparin into the wall of said vessel at said location, said administration taking place over a period of at least 24 hours and being characterized by a rate and dosage selected to be: a) high enough to control proliferation of smooth muscle cells in said vessel wall at said location; and b) low enough to avoid transport of said heparin through said vessel wall to establish a heparin level in the blood system equivalent to an anticoagulant heparin level that would have a discernable effect on clotting function as measured by activated prothrombin time (aPTT).
Claim 8
Dependent Claim
11 words
The method of claim 5 wherein said heparin is non-anticoagulant heparin.
Claim 9
Dependent Claim
11 words
The method of claim 5 wherein said heparin is anticoagulant heparin.
Claim 10
Dependent Claim
12 words
The method of claim 5 wherein said blood vessel is an artery.
Claim 11
Dependent Claim
19 words
The method of claim 8 wherein said biocompatible polymer based heparin releasing system comprises an aqueous gel or foam.
Claim 12
Dependent Claim
21 words
The method of claim 5 comprising treating said tissue to promote healing after surgical repair of said vessel at said location.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-10-02 | 1999-04-03 | 1999-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-02 | 2003-04-03 | 2003-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-02 | 2007-04-03 | 2007-10-03 | $7700.00 | Window Closed / Lapsed |