US5100689A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Surface modified surgical instruments, devices, implants, contact lenses and the like
Assignee: University of Florida Research Foundation Inc
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Filing: 1990-10-05
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Granted: 1992-03-31
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Expires: 2010-10-05
Abstract
Abstract Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma-irradiation or electron beam-irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted for contacting living tissue,the improvement comprising carrying out the graft polymerization in an aqueous solution under specific combinations of the following conditions: 1) monomer concentration in the range of from about 0.1% to about 50%, by weight; 2) total gamma or electron beam irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and 3) gamma dose rate in the range of from about 10 to about 2500 rads/min or electron beam-irradiation dose rate in the range of from about 10 to about 108 rads/min.
Inventors
- 👤 Eugene P. Goldberg
- 👤 James W. Burns
- 👤 G. Sudesh Kumar
- 👤 David C. Osborn
- 👤 Jeffrey A. Larson
- 👤 John W. Sheets
- 👤 Ali Yahiaoui
- 👤 Richard Robinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:33
CPC Classifications
C; C08; C08L; C08L33/00; C08L33/04; C08L33/14; A; A61; A61L; A61L27/00; A61L27/14; A61L27/16; A61L33/00; A61L33/0076; A61L33/0088; C08J; C08J7/00; C08J7/12; C08J7/16; C08J7/18; C08L39/00; C08L39/04; C08L39/06; G; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/145; A61F2/16; A61F2/0077; A61F2002/009; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2400/00; A61L2400/18; A61L2430/00; A61L2430/16; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
193 words
In a method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethylmethacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt. %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising: conducting said gamma-irradiation induced graft polymerization in an aqueous solution under the following conditions: a) monomer concentration in the range of from about 0.1% to about 50%, by weight; b) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad; and c) gamma dose rate in the range of from about 10 to about 2500 rads/min.
Claim 2
Dependent Claim
193 words
In a method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethylmethacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt. %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising: conducting said gamma-irradiation induced graft polymerization in an aqueous solution under the following conditions: a) monomer concentration in the range of from about 0.1% to about 50%, by weight; b) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad; and c) gamma dose rate in the range of from about 10 to about 2500 rads/min.
Claim 3
Dependent Claim
72 words
The method of claim 1 further including one or more of the following conditions: d) substantially excluding free oxygen from said graft polymerization solution; e) maintaining the thickness of said polymer coating in the range of from about 100 Å to about 100 microns; f) including a free radical scavenger in said aqueous graft polymerization solution; and g) including in said aqueous graft polymerization solution a swelling solvent for said plastic surface.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said article is a surgical instrument.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said article is a medical device.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said article is a prosthetic implant.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein said article is a soft or hard contact lens.
Claim 8
Dependent Claim
20 words
The method of claim 1 wherein said ionic monomer is a vinylsulfonic acid, a vinylcarboxylic acid or a salt thereof.
Claim 9
Dependent Claim
15 words
The method of claim 7 wherein said vinyl-carboxylic acid is acrylic, methacrylic or crotonic acid.
Claim 10
Dependent Claim
18 words
The method of claim 7 wherein said vinylsulfonic acid is sulfoethylmethacrylate, sulfopropylmethacrylate, styrene sulfonic acid or vinylsulfonic acid.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein said ionic monomer is an amino-functional monomer.
Claim 12
Dependent Claim
19 words
The method of claim 10 wherein said amino-functional monomer is a vinylpyridine, an amino-styrene, an aminoacrylate or an aminomthacrylate.
Claim 13
Dependent Claim
35 words
The method of claim 1 wherein said plastic is selected from the group consisting of polyacrylates, polymethacrylates, polyolefins, ethylene-propylene copolymers, polybutadiene, styrene-butadiene copolymers, styrene-ethylene-butadiene copolymers, polycarbonates, fluorocarbon polymers, polysiloxanes, polyurethanes, polyvinylchloride, polyesters and mixtures thereof.
Claim 14
Independent Claim
198 words
A method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by electron beam-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethylmethacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt. %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface comprising: conducting said electron beam-irradiation induced graft polymerization in an aqueous solution under the following conditions: a) monomer concentration in the range of from about 0.1% to about 50%, by weight; b) total electron beam irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and c) an electron beam irradiation dose rate in the a range of from about 10 to about 10 8 rads/min.
Claim 15
Independent Claim
198 words
A method for modifying a plastic surface of an article, said surface adapted for contact with living tissue of a human or non-human animal, by electron beam-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethylmethacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt. %, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophilic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), or IV. a copolymer of (NVP), (HEMA) or (NVP-HEMA) and said ionic monomer, on said surface comprising: conducting said electron beam-irradiation induced graft polymerization in an aqueous solution under the following conditions: a) monomer concentration in the range of from about 0.1% to about 50%, by weight; b) total electron beam irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and c) an electron beam irradiation dose rate in the a range of from about 10 to about 10 8 rads/min.
Claim 16
Dependent Claim
12 words
An article prepared according to the method of claim 1 or 13.
Claim 17
Dependent Claim
17 words
An article according to claim 14 comprising a surgical instrument, medical device, prosthetic implant or contact lens.
References Cited (Backward Citations)
US4897433A
Cited
US4961954A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-03-31 | 1995-09-30 | 1996-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-31 | 1999-09-30 | 2000-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-31 | 2003-09-30 | 2004-03-31 | $7700.00 | Window Closed / Lapsed |