Patent US5413989A successfully refreshed from Google Patents.
US5413989A
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US
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Method and activin compositions for inducing bone growth
Assignee: Celtrix Pharmaceuticals Inc
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Filing: 1993-05-03
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Granted: 1995-05-09
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Expires: 2013-05-03
Abstract
Abstract Activin is administered systemically and locally to induce the growth of mature bone. Activin enhances the level of bone formation and the quality of the bone formed when administered locally with BMP or bone marrow. Administration of activin by subcutaneous route promotes systemic increase in the bone mass.
Inventors
- 👤 Yasushi Ogawa
- 👤 David K. Schmidt
- 👤 Rosa Armstrong
- 👤 Ranga Nathan
- 👤 Andrea Y. Thompson
- 👤 Saeid M. Seyedin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:25
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; A; A61; A61K; A61K35/00; A61K35/12; A61K35/28; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1841; A61K38/1875; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/45
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
53 words
A composition for inducing deposition and maturation of bone in a subject in need thereof, comprising an osteogenically effective amount of activin in a pharmaceutically acceptable excipient and an effective amount of a BMP, wherein said BMP and said activin are present in a ratio of about 1:0.01 to about 1:100 by weight.
Claim 2
Dependent Claim
53 words
A composition for inducing deposition and maturation of bone in a subject in need thereof, comprising an osteogenically effective amount of activin in a pharmaceutically acceptable excipient and an effective amount of a BMP, wherein said BMP and said activin are present in a ratio of about 1:0.01 to about 1:100 by weight.
Claim 3
Dependent Claim
30 words
The composition of claim 1, further comprising an effective amount of bone marrow, wherein said activin and said bone marrow are present in a ratio of about 0.001 μg:1 g.
Claim 4
Dependent Claim
24 words
The composition of claim 1, wherein said BMP and said activin are present in a ratio of about 1:0.01 to about 1:1 by weight.
Claim 5
Dependent Claim
18 words
The composition of claim 1 wherein the pharmaceutically acceptable excipient comprises a mixture of collagen and calcium phosphate.
Claim 6
Dependent Claim
51 words
A composition for inducing deposition and maturation of bone in a subject in need thereof, comprising an osteogenically effective amount of activin in a pharmaceutically acceptable excipient and an effective amount of bone marrow, wherein said activin and said bone marrow are present in a ratio of about 0.001 μg:1 g.
Claim 7
Dependent Claim
51 words
A composition for inducing deposition and maturation of bone in a subject in need thereof, comprising an osteogenically effective amount of activin in a pharmaceutically acceptable excipient and an effective amount of bone marrow, wherein said activin and said bone marrow are present in a ratio of about 0.001 μg:1 g.
Claim 8
Dependent Claim
29 words
The composition of claim 5, wherein said activin and said bone marrow are present in a ratio of about 0.001 μg:1 g to about 100 mg:1 g by weight.
Claim 9
Independent Claim
32 words
A method for inducing deposition and maturation of bone in a subject in need thereof, comprising locally administering to the subject an osteogenically effective amount of activin in a pharmaceutically acceptable excipient.
Claim 10
Independent Claim
32 words
A method for inducing deposition and maturation of bone in a subject in need thereof, comprising locally administering to the subject an osteogenically effective amount of activin in a pharmaceutically acceptable excipient.
Claim 11
Dependent Claim
37 words
The method of claim 7, further comprising locally administering to the subject an effective amount of a BMP, wherein said BMP and said activin are present in a ratio of about 1:0.01 to about 1:100 by weight.
Claim 12
Dependent Claim
35 words
The method of claim 7, further comprising locally administering to the subject an effective amount of bone marrow, wherein said activin and said bone marrow are present in a ratio of about 0.001 μg:1 g.
Claim 13
Dependent Claim
24 words
The method of claim 9 wherein said activin and said bone marrow are administered locally to an area of bone in need of treatment.
Claim 14
Independent Claim
37 words
A method for inducing deposition and maturation of bone in a subject in need thereof, comprising administering to the subject an osteogenically effective amount of activin in a pharmaceutically acceptable excipient in a dental or orthopedic implant.
Claim 15
Independent Claim
37 words
A method for inducing deposition and maturation of bone in a subject in need thereof, comprising administering to the subject an osteogenically effective amount of activin in a pharmaceutically acceptable excipient in a dental or orthopedic implant.
Claim 16
Dependent Claim
38 words
The method of claim 11, further comprising administering an effective amount of TGF-β to the subject in a dental or orthopedic implant, wherein said activin and said TGF-β are present in a ratio of about 1:1 by weight.
Claim 17
Dependent Claim
42 words
The method of claim 11, further comprising administering an effective amount of a BMP to the subject in a dental or orthopedic implant, wherein said BMP and said activin are present in a ratio of about 1:0.01 to about 1:100 by weight.
Claim 18
Dependent Claim
38 words
The method of claim 13, further comprising administering an effective amount of TGF-β to the subject in a dental or orthopedic implant, wherein said activin and said TGF-β are present in a ratio of about 1:1 by weight.
Claim 19
Dependent Claim
40 words
The method of claim 11, further comprising administering to the subject an effective amount of bone marrow in a dental or orthopedic implant, wherein said activin and said bone marrow are present in a ratio of about 0.001 μg:1 g.
References Cited (Backward Citations)
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