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US5410516A Expired / Lapsed US ⏱️ 0.0 years remaining

Ultrasonic processes and circuits for performing them

Assignee: Bayer Intellectual Property GmbH
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Filing: 1993-06-14
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Granted: 1995-04-25
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Expires: 2013-06-14
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Abstract

Abstract A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examination area to be acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.

Inventors

  • 👤 Volkmar Uhlendorf
  • 👤 Thomas Fritzsch
  • 👤 Joachim Siegert

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:40
CPC Classifications
G; G01; G01S; G01S7/00; G01S7/52; G01S7/52017; G01S7/52023; G01S7/52036; G01S7/52038; A; A61; A61B; A61B8/00; G01N; G01N2291/00; G01N2291/02; G01N2291/024; G01N2291/02491; G01S15/00; G01S15/88; G01S15/89; G01S15/8906; G01S15/8979

Claims Analysis

Total Claims: 19
Claim 1
Independent Claim 196 words
An ultrasonic process for imaging and, optionally, for evaluation of a Doppler spectrum, of an object having limited resistance to sonic energy, in an inspection zone, which comprises: introducing into the inspection zone, the object to be imaged and an ultrasonic contrast medium that contains microbubbles as scattering bodies or that produces microbubbles upon exposure to ultrasonic waves, such that the contrast agent provides nonlinear vibrations of the microbubbles when irradiated in the inspection zone by irradiated ultrasonic waves, applying an HF burst of excitation frequency, f o , to electrically excite a wide-band, acoustically highly damped, electrically matched ultrasonic transducer having a transducer element or having several transducer elements, controllable individually or in groups, and thereby exposing the inspection zone to ultrasonic waves, f o , of 1 MHz to 22 MHz, and receiving by the ultrasonic transducer, the ultrasonic signal reflected from the inspection zone and scattered back from that zone, and processing the received ultrasonic signal for further evaluation, evaluating from the reflected and backscattered ultrasonic signal at least one of the harmonics, the subharmonics and the ultraharmonics of the excitation frequency, f o , and, optionally, the excitation frequency f o .
Claim 2
Dependent Claim 196 words
An ultrasonic process for imaging and, optionally, for evaluation of a Doppler spectrum, of an object having limited resistance to sonic energy, in an inspection zone, which comprises: introducing into the inspection zone, the object to be imaged and an ultrasonic contrast medium that contains microbubbles as scattering bodies or that produces microbubbles upon exposure to ultrasonic waves, such that the contrast agent provides nonlinear vibrations of the microbubbles when irradiated in the inspection zone by irradiated ultrasonic waves, applying an HF burst of excitation frequency, f o , to electrically excite a wide-band, acoustically highly damped, electrically matched ultrasonic transducer having a transducer element or having several transducer elements, controllable individually or in groups, and thereby exposing the inspection zone to ultrasonic waves, f o , of 1 MHz to 22 MHz, and receiving by the ultrasonic transducer, the ultrasonic signal reflected from the inspection zone and scattered back from that zone, and processing the received ultrasonic signal for further evaluation, evaluating from the reflected and backscattered ultrasonic signal at least one of the harmonics, the subharmonics and the ultraharmonics of the excitation frequency, f o , and, optionally, the excitation frequency f o .
Claim 3
Dependent Claim 194 words
An ultrasonic process for imaging and, optionally, for evaluation of a Doppler spectrum, of an object having limited resistance to sound energy, in an inspection zone, which comprises: introducing into the inspection zone the object to be imaged and an ultrasonic contrast agent that contains microbubbles as scattering bodies or that produces microbubbles upon exposure to ultrasonic waves, such that the contrast agent provides nonlinear vibrations of the microbubbles when irradiated in the inspection zone by ultrasonic waves, applying two HF bursts of excitation frequencies, f o and f p , to electrically excite a wide-band, acoustically highly damped, electrically matched ultrasonic transducer having a transducer element or having several transducer elements, controllable individually or in groups, wherein the excitation frequencies, f o and f p , are different and are each less than half the upper frequency limit of the working range of the ultrasonic transducer, and receiving by the ultrasonic transducer the ultrasonic signal reflected from the inspection zone and scattered back from that zone, and processing the received ultrasonic signal for further evaluation, evaluating from the reflected and backscattered ultrasonic signal the sum or the difference of the two excitation frequencies.
Claim 4
Dependent Claim 194 words
An ultrasonic process for imaging and, optionally, for evaluation of a Doppler spectrum, of an object having limited resistance to sound energy, in an inspection zone, which comprises: introducing into the inspection zone the object to be imaged and an ultrasonic contrast agent that contains microbubbles as scattering bodies or that produces microbubbles upon exposure to ultrasonic waves, such that the contrast agent provides nonlinear vibrations of the microbubbles when irradiated in the inspection zone by ultrasonic waves, applying two HF bursts of excitation frequencies, f o and f p , to electrically excite a wide-band, acoustically highly damped, electrically matched ultrasonic transducer having a transducer element or having several transducer elements, controllable individually or in groups, wherein the excitation frequencies, f o and f p , are different and are each less than half the upper frequency limit of the working range of the ultrasonic transducer, and receiving by the ultrasonic transducer the ultrasonic signal reflected from the inspection zone and scattered back from that zone, and processing the received ultrasonic signal for further evaluation, evaluating from the reflected and backscattered ultrasonic signal the sum or the difference of the two excitation frequencies.
Claim 5
Dependent Claim 20 words
The ultrasonic process according to claim 1, wherein the ultrasonic contrast agent is a solution, an emulsion or a suspension.
Claim 6
Dependent Claim 35 words
The ultrasonic process according to claim 3, wherein the contrast agent is a microbubble suspension having a concentration of from 10 -3 % by weight to 30% by weight dry substance in the suspension medium.
Claim 7
Dependent Claim 47 words
The ultrasonic process of claim 1, wherein the ultrasonic transducer is electrically excited by at least one function generator by means of which HF bursts of adjustable amplitude and adjustable excitation frequency, f o , 1 MHz to 22 MHz, with 0.5 to 30 cycles are generated.
Claim 8
Dependent Claim 26 words
The ultrasonic process of claim 5, wherein the excitation frequency, f o , is 1 MHz to 11 MHz and 1 to 5 cycles are generated.
Claim 9
Dependent Claim 63 words
The ultrasonic process of claim 2, wherein the two HF bursts are generated by two function generators and fed either to one ultrasonic transducer element or to two ultrasonic transducer elements, and wherein each function generator generates HF bursts of adjustable amplitude and adjustable excitation frequency, f o or f p , of 0.5 to 20 MHz with from 1 to 25 cycles.
Claim 10
Dependent Claim 28 words
The ultrasonic process of claim 7, wherein the excitation frequency, f o or f p , is 1 to 5 MHz and 1 to 10 cycles are generated.
Claim 11
Dependent Claim 29 words
The ultrasonic process of claim 1, wherein, from the reflected and backscattered ultrasonic signal, frequencies that are lower than the after frequency (f.sub.τ) of the ultrasonic transducer are evaluated.
Claim 12
Dependent Claim 38 words
The ultrasonic process of claim 1, wherein the evaluation is carried out by means of a computer-controlled gate circuit, at least one time window being selected and the associated frequency spectrum being determined in analog or digital manner.
Claim 13
Dependent Claim 31 words
The ultrasonic process of claim 10, wherein the length of the time window and the number of cycles per burst are adjusted according to a selected frequency resolution and spatial resolution.
Claim 14
Dependent Claim 20 words
The ultrasonic process according to claim 2, wherein the ultrasonic contrast agent is a solution, an emulsion or a suspension.
Claim 15
Dependent Claim 35 words
The ultrasonic process according to claim 12, wherein the contrast agent is a microbubble suspension having a concentration of from 10 -3 % by weight to 30% by weight dry substance in the suspension medium.
Claim 16
Dependent Claim 38 words
The ultrasonic process of claim 2, wherein the evaluation is carried out by means of a computer-controlled gate circuit, at least one time window being selected and the associated frequency spectrum being determined in analog or digital manner.
Claim 17
Dependent Claim 31 words
The ultrasonic process of claim 14, wherein the length of the time window and the number of cycles per burst are adjusted according to a selected frequency resolution and spatial resolution.
Claim 18
Dependent Claim 172 words
A circuit for carrying out the ultrasonic process of claim 1 comprising: an ultrasonic transducer having n ultrasonic transducer elements which receive signals in phase-delayed manner, a function generator, the output (2) of which is connected by way of an n-way signal divider (5), to n computer-controlled time-delay circuits (7.1.1 . . . 7.n.1) and n transmitter/receiver switches (3.1.1 . . . 3.n.1) controlled by the function generator (1) or by a computer, connected to the inputs of the ultrasonic transducer elements, the outputs of the ultrasonic transducer elements connected, by way of the n transmitter/receiver switches (3.1.1 . . . 3.1.n), each to a further m-way signal divider (10) which divides the signals m number of ways, the m-way signal dividers (10) being connected by way of m time-delay circuits (11), by way of m fixed or variable circuits (12) for frequency band selection and by way of a circuit for phase-correct summation and signal division to a system for the selective further processing individually or in parallel--of m frequency bands.
Claim 19
Dependent Claim 171 words
A circuit for carrying out the ultrasonic process of claim 2 comprising: an ultrasonic transducer having n ultrasonic transducer elements which receive signals in phase-delayed manner, first and second function generators, the outputs of which are connected by way of two n-way signal dividers, to n computer-controlled time-delay circuits (7.1.1 . . . 7.n.1) and n transmitter/receiver switches (3.1.1 . . . 3.n.1) controlled by the function generator (1) or by a computer, connected to the inputs of the ultrasonic transducer elements, the outputs of the ultrasonic transducer elements connected, by way of the n transmitter/receiver switches (3.1.1 . . . 3.1.n), each to a further m-way signal divider (10) which divides the signals m number of ways, the m-way signal dividers (10) being connected by way of m time-delay circuits (11), by way of m fixed or variable circuits (12) for frequency band selection and by way of a circuit for phase-correct summation and signal division to a system for the selective further processing--individually or in parallel--of m frequency bands.

References Cited (Backward Citations)

US3640271A Cited
US4452082A Cited
US4483345A Cited
US4532812A Cited
US4610255A Cited
US5255683A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1998-04-24 1998-10-24 1999-04-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2002-04-24 2002-10-24 2003-04-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2006-04-24 2006-10-24 2007-04-25 $7700.00 Window Closed / Lapsed

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