US5401730A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for reducing platelet aggregation
Assignee: Hope Heart Institute
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Filing: 1993-04-22
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Granted: 1995-03-28
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Expires: 2013-04-22
Abstract
Abstract Patients having a predisposition for thrombus formation are effectively treated with compositions of acetylsalicylic acid, citric acid, thiamine and/or a zinc salt. The combination of aspirin and citric acid has been found to be significantly more effective in inhibiting platelet aggregability than aspirin alone, and thiamine contributes to the reduction in thrombotic potential by reducing plasma fibrinogen levels. Accordingly, new methods and compositions are disclosed for reducing the thrombotic potential of human or animal subjects, such as in the prophylaxis or treatment of atherosclerosis, vascular surgery patients or other cardiovascular diseases.
Inventors
- 👤 Lester R. Sauvage
- 👤 Svetlana Kaplan
- 👤 Alexander Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/506; A61K31/51; A61K31/618; A61K31/621; A61K33/00; A61K33/24; A61K33/30; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
72 words
A method of treating a patient comprising administering to the patient a composition comprising at least about 0.5 mg of acetylsalicylic acid per kg of body weight of the patient per day, and at least about 0.5 mg of citric acid per kg of body weight of the patient per day, whereby the platelet aggregation of the patient is reduced more than if the patient had been treated with acetylsalicylic acid alone.
Claim 2
Independent Claim
72 words
A method of treating a patient comprising administering to the patient a composition comprising at least about 0.5 mg of acetylsalicylic acid per kg of body weight of the patient per day, and at least about 0.5 mg of citric acid per kg of body weight of the patient per day, whereby the platelet aggregation of the patient is reduced more than if the patient had been treated with acetylsalicylic acid alone.
Claim 3
Dependent Claim
31 words
The method of claim 1 wherein from about 2 to about 4 mg of acetylsalicylic acid per kg of body weight of the patient per day is administered to the patient.
Claim 4
Dependent Claim
31 words
The method of claim 1 wherein from about 2 to about 4 mg of citric acid per kg of body weight of the patient per day is administered to the patient.
Claim 5
Dependent Claim
30 words
The method of claim 1 which further comprises administering to the patient an amount of a pharmaceutically acceptable zinc salt effective to reduce the platelet aggregation activity of the patient.
Claim 6
Dependent Claim
29 words
The method of claim 4 wherein at least about 0.01 mg of a pharmaceutically acceptable zinc salt per kg of body weight per day is administered to the patient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-03-27 | 1998-09-26 | 1999-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-27 | 2002-09-26 | 2003-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-27 | 2006-09-26 | 2007-03-28 | $7700.00 | Window Closed / Lapsed |