US4080446A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Suppression of thrombocyte aggregation
Assignee: Merck Patent GmbH
•
Filing: 1976-11-04
•
Granted: 1978-03-21
•
Expires: 1996-11-04
Abstract
Abstract 2-(4,5-BIS-P-CHLOROPHENYLOXAZOL-2-YL-MERCAPTO)-PROPIONIC ACID AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS IS USEFUL FOR SUPPRESSING AGGREGATION OF THROMBOCYTES, PARTICULARLY WHEN ADMINISTERED IN COMBINATION WITH ASPIRIN.
Inventors
- 👤 Gotz Leopold
- 👤 Reinhard Lissner
- 👤 Jurgen Maisenbacher
- 👤 Werner Mehrhof
- 👤 Joachim Gante
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:35
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/42; A61K31/60; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
48 words
A pharmaceutical composition comprising a mixture of (a) a thrombocyte aggregation inhibiting amount per unit dosage of 2-(4,5-bis-p-chlorophenyl-oxazol-2-yl-mercapto)-propionic acid, or a physiologically acceptable salt thereof, and (b) acetylsalicylic acid or a physiologically acceptable salt thereof, in a molar ratio of (b) to (a) of from 60:1 to 0.1:1.
Claim 2
Dependent Claim
48 words
A pharmaceutical composition comprising a mixture of (a) a thrombocyte aggregation inhibiting amount per unit dosage of 2-(4,5-bis-p-chlorophenyl-oxazol-2-yl-mercapto)-propionic acid, or a physiologically acceptable salt thereof, and (b) acetylsalicylic acid or a physiologically acceptable salt thereof, in a molar ratio of (b) to (a) of from 60:1 to 0.1:1.
Claim 3
Dependent Claim
20 words
A composition according to claim 1 wherein the molar ratio therein of (b) to (a) is from 2:1 to 0.5:1.
Claim 4
Dependent Claim
18 words
A composition according to claim 1 wherein the molar ratio therein of (b) to (a) is about 1:1.
Claim 5
Dependent Claim
25 words
A composition according to claim 1 adapted for oral administration containing per dosage unit 5 to 300 mg of (b) and 5 to 40 (a).
Claim 6
Dependent Claim
14 words
A composition according to claim 4 in the form of tablets, dragees or capsules.
Claim 7
Dependent Claim
17 words
A composition according to claim 5 wherein both (a) and (b) are present therein as free acids.
Claim 8
Independent Claim
41 words
A method of inhibiting thrombocyte aggregation in human patients in which there exists a high risk of arterial or venous thrombosis, which comprises administering thereto an amount of 2-(4,5-bis-p-chlorophenyl-oxazol-2-yl-mercapto)-propionic acid or a physiologically acceptable salt thereof, effective to inhibit thrombocyte aggregation.
Claim 9
Independent Claim
41 words
A method of inhibiting thrombocyte aggregation in human patients in which there exists a high risk of arterial or venous thrombosis, which comprises administering thereto an amount of 2-(4,5-bis-p-chlorophenyl-oxazol-2-yl-mercapto)-propionic acid or a physiologically acceptable salt thereof, effective to inhibit thrombocyte aggregation.
Claim 10
Dependent Claim
16 words
A method according to claim 7 wherein the propionic acid or salt thereof is administered orally.
Claim 11
Dependent Claim
16 words
A method according to claim 7 wherein the propionic acid or salt thereof is administered daily.
Claim 12
Dependent Claim
41 words
A method according to claim 7 wherein the propionic acid or salt thereof is administered in admixture with acetylsalicylic acid or a physiologically acceptable salt thereof in a molar ratio of the latter to the former of from 2:1 to 0.5:1.
Claim 13
Dependent Claim
13 words
A method according to claim 10 wherein the molar ratio is about 1:1.
Claim 14
Dependent Claim
12 words
A method according to claim 10 wherein the mixture is administered orally.
Claim 15
Dependent Claim
12 words
A method according to claim 10 wherein the mixture is administered daily.
References Cited (Backward Citations)
US3933840A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |