US5399158A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of lysing thrombi
Assignee: United States Department of the Army
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Filing: 1993-01-27
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Granted: 1995-03-21
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Expires: 2013-01-27
Abstract
Abstract This invention relates to the prevention and treatment of thrombi using plasminogen activators, including t-PA, urokinases, and streptokinases, in conjunction with intermittent (pulsed mode) ultrasound. A preferred modality interposes liquid-containing interface between the skin of the patient and the transducer of the ultrasound generator.
Inventors
- 👤 Carl G. Lauer
- 👤 Barbara Alving
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:35
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/22; A61B17/22004; A61B2017/22082; A61B2017/22084
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
94 words
A non-invasive method of lysing thrombi comprising the steps of: 1) adminstering a plasminogen activating effective amount of at least one plasminogen activating factor to a patient suffering from thrombosis; 2) placing aganist a body surface of said patient which is near said thrombus a liquid-containing structure or a material to form an interface aganist which the contact surface of the transducer of an ultrasound generator is placed; and 3) adminstering intermittent (pluse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 2
Dependent Claim
94 words
A non-invasive method of lysing thrombi comprising the steps of: 1) adminstering a plasminogen activating effective amount of at least one plasminogen activating factor to a patient suffering from thrombosis; 2) placing aganist a body surface of said patient which is near said thrombus a liquid-containing structure or a material to form an interface aganist which the contact surface of the transducer of an ultrasound generator is placed; and 3) adminstering intermittent (pluse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 3
Dependent Claim
13 words
A method of claim 1 wherein the plasminogen activating agent is a t-PA.
Claim 4
Dependent Claim
13 words
A method of claim 1 wherein the plasminogen activating agent is a streptokinase.
Claim 5
Dependent Claim
13 words
A method of claim 1 wherein the plasminogen activating agent is a urokinase.
Claim 6
Dependent Claim
21 words
A method of claim 1 wherein the frequency is 0.1 to 3MHz and the power range is 0.5-3 watts/cm 2 .
Claim 7
Dependent Claim
96 words
A non-invasive method of preventing formation of thrombi comprising the steps of: 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a mammal; 2) placing aganist a body surface of said mammal which is near an area likely to develop a thrombus a liquid-containing structure or a material to form an interface aganist which the contact surface of an ultrasound generator transducer is placed; and 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 8
Dependent Claim
96 words
A non-invasive method of preventing formation of thrombi comprising the steps of: 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a mammal; 2) placing aganist a body surface of said mammal which is near an area likely to develop a thrombus a liquid-containing structure or a material to form an interface aganist which the contact surface of an ultrasound generator transducer is placed; and 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 9
Dependent Claim
13 words
A method of claim 6 wherein the plasminogen activating agent is a t-PA.
Claim 10
Dependent Claim
13 words
A method of claim 6 wherein the plasminogen activating agent is a streptokinase.
Claim 11
Dependent Claim
13 words
A method of claim 6 wherein the plasminogen activating agent is a urokinase.
Claim 12
Dependent Claim
21 words
A method of claim 6 wherein the frequency is 0.1 to 3MHz and the power range is 0.5-3 watts/cm 2 .
Claim 13
Dependent Claim
78 words
A non-invasive method of lysing thrombi comprising the steps of: 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a patient suffering from thrombosis; 2) placing aganist a body surface of said patient which is near said thrombus a contact surface of an ultrasound generator transducer and 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 14
Dependent Claim
78 words
A non-invasive method of lysing thrombi comprising the steps of: 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a patient suffering from thrombosis; 2) placing aganist a body surface of said patient which is near said thrombus a contact surface of an ultrasound generator transducer and 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 15
Dependent Claim
13 words
A method of claim 11 wherein the plasminogen activating agent is a t-PA.
Claim 16
Dependent Claim
13 words
A method of claim 11 wherein the plasminogen activating agent is a streptokinase.
Claim 17
Dependent Claim
13 words
A method of claim 11 wherein the plasminogen activating agent is a urokinase.
Claim 18
Dependent Claim
21 words
A method of claim 11 wherein the frequency is 0.1 to 3MHz and the power range is 0.5-3 watts/cm 2 .
Claim 19
Dependent Claim
80 words
A non-invasive method of preventing formation of thrombi comprising the steps of: 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a mammal; 2) placing aganist surface of mammal which is near said the area likely to develop a thrombus a contact surface of an ultrasound generator transducer; and 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 20
Dependent Claim
80 words
A non-invasive method of preventing formation of thrombi comprising the steps of: 1) administering a plasminogen activating effective amount of at least one plasminogen activating factor to a mammal; 2) placing aganist surface of mammal which is near said the area likely to develop a thrombus a contact surface of an ultrasound generator transducer; and 3) administering intermittent (pulse mode) ultrasound at a thrombus lysing effective frequency and power such that said frequency and power are acoustic streaming-inducing and non-cavitational.
Claim 21
Dependent Claim
13 words
A method of claim 16 wherein the plasminogen activating agent is a t-PA.
Claim 22
Dependent Claim
13 words
A method of claim 16 wherein the plasminogen activating agent is a streptokinase.
Claim 23
Dependent Claim
13 words
A method of claim 16 wherein the plasminogen activating agent is a urokinase.
Claim 24
Dependent Claim
21 words
A method of claim 16 wherein the frequency is 0.1 to 3MHz and the power range is 0.5-3 watts/cm 2 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-03-20 | 1998-09-19 | 1999-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-20 | 2002-09-19 | 2003-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-20 | 2006-09-19 | 2007-03-21 | $7700.00 | Window Closed / Lapsed |