Abstract The present invention describes a catheter suitable for introduction into a tubular tissue for dissolving blockages in such tissue. The catheter is particularly useful for removing thrombi within blood vessels. In accordance with the preferred embodiments, a combination of vibrating motion and injection of a lysing agent is utilized to break up blockages in vessels. The vessels may be veins, arteries, ducts, intestines, or any lumen within the body that may become blocked from the material that flows through it. As a particular example, dissolution of vascular thrombi is facilitated by advancing a catheter through the occluded vessel, the catheter causing a vibrating, stirring action in and around the thrombus usually in combination with the dispensing of a thrombolytic agent such as urokinase into the thrombus. The catheter has an inflatable or expandable member near the distal tip which, when inflated or expanded, prevents the passage of dislodged thrombus around the catheter. The dislodged portions of thrombus are directed through a perfusion channel in the catheter, where they are removed by filtration means housed with the perfusion channel before the blood exits the tip of the catheter. Catheters that allow both low frequency (1-1000 Hz) vibratory motion and delivery of such agents to a blockage and a method for using such catheters are disclosed.
An apparatus for the removal of an obstruction in tubular tissue of a patient comprising an elongate tubular catheter having a proximal end and a distal end and a body portion therebetween, said body portion having at least two lumens and an outer tissue-contacting surface substantially coextensive therewith, said outer tissue-contacting surface being dimensioned to fit within said tubular tissue and said tissue-contacting surface having at least one lysing agent dispensing opening therein and an inflatable member coextensive and coaxial with at least a portion thereof, said inflatable member being distal to said at least one lysing agent dispensing opening; the proximal end of the catheter being trifurcated to form first, second and third projections, the first projection being in material vibratory communication with said tissue-contacting surface and adapted to receive and matingly engage a vibrating element; the second projection providing an injection port which is in fluid communication with said inflatable member, and said third projection forming a lysing agent injection port which is in fluid communication with at least one lysing agent dispensing opening; and wherein said vibrating element produces translational and/or rotational mechanical vibrations between 1-1000 Hz.
Claim 2
Independent Claim
190 words
An apparatus for the removal of an obstruction in tubular tissue of a patient comprising an elongate tubular catheter having a proximal end and a distal end and a body portion therebetween, said body portion having at least two lumens and an outer tissue-contacting surface substantially coextensive therewith, said outer tissue-contacting surface being dimensioned to fit within said tubular tissue and said tissue-contacting surface having at least one lysing agent dispensing opening therein and an inflatable member coextensive and coaxial with at least a portion thereof, said inflatable member being distal to said at least one lysing agent dispensing opening; the proximal end of the catheter being trifurcated to form first, second and third projections, the first projection being in material vibratory communication with said tissue-contacting surface and adapted to receive and matingly engage a vibrating element; the second projection providing an injection port which is in fluid communication with said inflatable member, and said third projection forming a lysing agent injection port which is in fluid communication with at least one lysing agent dispensing opening; and wherein said vibrating element produces translational and/or rotational mechanical vibrations between 1-1000 Hz.
Claim 3
Dependent Claim
20 words
The apparatus of claim 1 wherein said tubular tissue is a blood vessel and said obstruction is a blood clot.
Claim 4
Dependent Claim
24 words
The apparatus of claim 1 further comprising a reservoir for containing said lysing agent and a pump for metering said lysing agent injection port.
Claim 5
Dependent Claim
72 words
A method of removing a clot from an obstructed blood vessel comprising the steps of inserting the apparatus of claim 1 into said obstructed blood vessel and advancing the distal tip of the catheter along the vessel until the inflatable member is beyond the clot, inflating said inflatable member by injecting a fluid into said second projection then dispensing lysing agent into or around the clot while the distal tip is vibrating.