X-ray contrast compositions containing an organic crystalline X-ray contrast agent and a cellulose derivative

Claim 1

An x-ray contrast composition for oral or retrograde examination of the gastrointestinal tract comprising: (a) from about 40 to 160 mg of iodine per ml of the composition of crystalline contrast agent selected from the group consisting of diatrizoic acid, metrizoic acid, iothalamic acid, trimesic acid, urokonic acid, ioxathalamic acid, tetraiodoterephthalic acid, ioxaglic acid, iodipamide, ethyl-3,5-diacetamido-2,4,6triiodobenzoate, ethyl-2-(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)butyrate, and ethyl(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)-acetate, said crystalline contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of from about 0.5 μ to about 100 μ; and said surface modifier is selected from the group consisting of a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine; (b) from 0.1 to 4% w/v of a cellulose derivative selected from the group consisting of methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxyethyl methylcellulose, hydroxypropyl methylcellulose and microcrystalline cellulose; (c) from 0.1 to 25% w/v of an oily vehicle; (d) from 0.1 to 10% w/v of a surfactant selected from the group consisting of nonionic, anionic, cationic and zwitterionic surfactants; (e) from 0.001 to 4% w/v of a viscosity modifying excipient; and (f) water to make 100% by volume.

Claim 8

A method of carrying out x-ray examination of the gastrointestinal tract of a patient, said method comprises the oral or rectal administration to the patient an x-ray contrast composition comprising: (a) from about 40 to 160 mg of iodine per ml of the composition of crystalline contrast agent selected from the group consisting of diatrizoic acid, metrizoic acid, iothalamic acid, trimesic acid, urokonic acid, ioxathalamic acid, tetraiodoterephthalic acid, ioxaglic acid, iodipamide, ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, ethyl-2-(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)butyrate, and ethyl(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)-acetate, said crystalline contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of from about 0.5 μ to about 100 μ; and said surface modifier is selected from the group consisting of a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine; (b) from 0.1 to 4% w/v of a cellulose derivative selected from the group consisting of methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxyethyl methylcellulose, hydroxypropyl methylcellulose and microcrystalline cellulose; (c) from 0.1 to 25% w/v of an oily vehicle; (d) from 0.1 to 10% w/v of a surfactant selected from the group consisting of nonionic, anionic, cationic and zwitterionic surfactants; (e) from 0.001 to 4% w/v of a viscosity modifying excipient; and (f) water to make 100% by volume.

Claim 9

A method of carrying out x-ray examination of the gastrointestinal tract of a patient, said method comprises the oral or rectal administration to the patient an x-ray contrast composition comprising: (a) from about 40 to 160 mg of iodine per ml of the composition of crystalline contrast agent selected from the group consisting of diatrizoic acid, metrizoic acid, iothalamic acid, trimesic acid, urokonic acid, ioxathalamic acid, tetraiodoterephthalic acid, ioxaglic acid, iodipamide, ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, ethyl-2-(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)butyrate, and ethyl(3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)-acetate, said crystalline contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of from about 0.5 μ to about 100 μ; and said surface modifier is selected from the group consisting of a tetrafunctional block copolymer derived from sequential addition of propylene oxide and ethylene oxide to ethylenediamine; (b) from 0.1 to 4% w/v of a cellulose derivative selected from the group consisting of methylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxyethyl methylcellulose, hydroxypropyl methylcellulose and microcrystalline cellulose; (c) from 0.1 to 25% w/v of an oily vehicle; (d) from 0.1 to 10% w/v of a surfactant selected from the group consisting of nonionic, anionic, cationic and zwitterionic surfactants; (e) from 0.001 to 4% w/v of a viscosity modifying excipient; and (f) water to make 100% by volume.