Patent US3591482A successfully refreshed from Google Patents.
US5350583A
Expired / Lapsed
US
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Cell-penetrable medical material and artificial skin
Assignee: OSferionBiomaterials Corp
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Filing: 1992-11-03
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Granted: 1994-09-27
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Expires: 2012-11-03
Abstract
Abstract Cell-penetrable medical material made of denatured collagen which is prepared by heating, in the presence of water is disclosed, the collagen having cross-linking structure. Artificial skin prepared by using this medical material as a wound-contacting layer (2) is also disclosed.
Inventors
- 👤 Katsutoshi Yoshizato
- 👤 Jun Konishi
- 👤 Mikio Koide
- 👤 Kaori Oyamada
- 👤 Ken-ichi Ohsaki
- 👤 Takeo Katakura
- 👤 Yuichi Mori
- 👤 Ken Tatebe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/56; A61L27/60; C; C12; C12N; C12N5/00; C12N5/0062; C12N5/0068; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
83 words
Artificial skin which is suitable for application to the site of a wound comprising: a wound-contacting layer; and a water permeation-controlling area laminated on one side said wound-contacting layer for controlling water permeation; said wound-contacting layer being made of denatured collagen obtained by heating cross-linked collagen in the presence of water at a temperature ranging from about 50° to about 125° C. and wherein said denatured collagen lacks antigenicity as the antigenic moiety at the terminus of the collagen molecule has been removed.
Claim 2
Dependent Claim
83 words
Artificial skin which is suitable for application to the site of a wound comprising: a wound-contacting layer; and a water permeation-controlling area laminated on one side said wound-contacting layer for controlling water permeation; said wound-contacting layer being made of denatured collagen obtained by heating cross-linked collagen in the presence of water at a temperature ranging from about 50° to about 125° C. and wherein said denatured collagen lacks antigenicity as the antigenic moiety at the terminus of the collagen molecule has been removed.
Claim 3
Dependent Claim
15 words
Artificial skin according to claim 1, in which said wound-contacting layer comprises a sponge form.
Claim 4
Dependent Claim
20 words
Artificial skin according to claim 1, in which said denatured collagen has a helix content rate of 0 to 80%.
Claim 5
Dependent Claim
31 words
Artificial skin according to claim 1, in which said water permeation-controlling layer is made of non-toxic material selected from the group consisting of silicone resin, polyacrylate ester, polymethacrylate ester and polyurethane.
Claim 6
Dependent Claim
23 words
Artificial skin according to claim 1, in which said water permeation-controlling layer has water flux of about 0.1 to 1 mg/cm 2 /hour.
Claim 7
Dependent Claim
24 words
Artificial skin according to claim 2, in which at least one of wound-contacting layer, supporting layer and water permeation-controlling layer contains an antibacterial agent.
Claim 8
Dependent Claim
24 words
Artificial skin according to claim 6, in which said antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamycin and silver nitrate.
Claim 9
Dependent Claim
13 words
Artificial skin according to claim 1, in which said collagen is fibrous collagen.
Claim 10
Dependent Claim
24 words
Artificial skin according to claim 1, in which at least one of said wound-contacting layer and said water permeation-controlling layer contains an antibacterial agent.
Claim 11
Dependent Claim
24 words
Artificial skin according to claim 9, in which said antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamicin and silver nitrate.
Claim 12
Dependent Claim
22 words
The artificial skin of claim 1, wherein said heating is effected at a temperature ranging from about 90° to about 121° C.
Claim 13
Dependent Claim
98 words
Artificial skin which is suitable for application to the site of a wound comprising: a supporting layer having a top and bottom side; a wound contacting layer laminated to said bottom side of said supporting layer; and a water permeation-controlling layer laminated to said top side of said supporting layer, said wound-contacting layer comprising denatured collagen obtained by heating cross-linked collagen in the presence of water at a temperature ranging from about 50° to about 125° C. and wherein said denatured collagen lacks antigenicity as the antigenic moiety at the terminus of the collagen molecule has been removed.
Claim 14
Dependent Claim
98 words
Artificial skin which is suitable for application to the site of a wound comprising: a supporting layer having a top and bottom side; a wound contacting layer laminated to said bottom side of said supporting layer; and a water permeation-controlling layer laminated to said top side of said supporting layer, said wound-contacting layer comprising denatured collagen obtained by heating cross-linked collagen in the presence of water at a temperature ranging from about 50° to about 125° C. and wherein said denatured collagen lacks antigenicity as the antigenic moiety at the terminus of the collagen molecule has been removed.
Claim 15
Dependent Claim
15 words
Artificial skin according to claim 12, in which said wound-contacting layer comprise a sponge form.
Claim 16
Dependent Claim
20 words
Artificial skin according to claim 12, in which said denatured collagen has a helix content rate of 0 to 80%.
Claim 17
Dependent Claim
31 words
Artificial skin according to claim 12, in which said water permeation-controlling layer is made of non-toxic material selected from the group consisting of silicone resin, polyacrylate ester, polymethacrylate ester and polyurethane
Claim 18
Dependent Claim
24 words
Artificial skin according to claim 12, in which said water permeation-controlling layer has a water flux of about 0.1 to 1 mg/cm 2 /hour.
Claim 19
Dependent Claim
13 words
Artificial skin according to claim 12, in which said supporting layer is fibroin.
Claim 20
Dependent Claim
20 words
Artificial skin according to claim 12, in which said water permeation controlling layer is about 5 to 200 μm thick.
Claim 21
Dependent Claim
22 words
The artificial skin of claim 12, wherein said heating is effected at a temperature ranging from about 90° to about 121° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-26 | 1998-03-28 | 1998-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-26 | 2002-03-28 | 2002-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-26 | 2006-03-28 | 2006-09-27 | $7700.00 | Window Closed / Lapsed |