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US5346993A
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Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
Assignee: Ludwig Cancer Research
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Filing: 1993-07-15
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Granted: 1994-09-13
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Expires: 2013-07-15
Abstract
Abstract The invention relates to large latent complexes of TGF-β2 and TGF-β3, and methods for isolating these. The complex consists of a dimerized form of TGF-β2 or TGF-β3, the appropriate latency associated peptide, and the latent TGF-β1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-β1, TGF-β2 and TGF-β3, but is immunologically distinct from LTBP, referred to as LTBP-2.
Inventors
- 👤 Kohei Miyazono
- 👤 Carl-Henrik Heldin
- 👤 Anders Olofsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:22
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
63 words
Isolated molecular complex consisting of; (i) a molecule of LTBP-2 binding protein, which is immunologically distinct from latent, TGF-β1 binding protein and has a molecular mass of about 150 KDa as determined by SDS-PAGE; (ii) dimerized, beta latency associated peptide linked to said LTBP-2 binding protein via a disulphide bond, and; (iii) dimerized TGF-β, non-covalently associated with said dimerized, beta latency associated peptide.
Claim 2
Dependent Claim
63 words
Isolated molecular complex consisting of; (i) a molecule of LTBP-2 binding protein, which is immunologically distinct from latent, TGF-β1 binding protein and has a molecular mass of about 150 KDa as determined by SDS-PAGE; (ii) dimerized, beta latency associated peptide linked to said LTBP-2 binding protein via a disulphide bond, and; (iii) dimerized TGF-β, non-covalently associated with said dimerized, beta latency associated peptide.
Claim 3
Dependent Claim
13 words
The isolated molecular complex of claim 1, wherein said TGF-β molecule is TGF-β1.
Claim 4
Dependent Claim
13 words
The isolated molecular complex of claim 1, wherein said TGF-β molecule is TGF-β2.
Claim 5
Dependent Claim
13 words
The isolated molecular complex of claim 1, wherein said TGF-β molecule is TGF-β3.
References Cited (Backward Citations)
US4931548A
Cited
US5177197A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-12 | 1998-03-14 | 1998-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-12 | 2002-03-14 | 2002-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-12 | 2006-03-14 | 2006-09-13 | $7700.00 | Window Closed / Lapsed |