US5344456A
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Materials for living hard tissue replacements
Assignee: TDK Corp
•
Filing: 1992-04-21
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Granted: 1994-09-06
•
Expires: 2012-04-21
Abstract
Abstract The materials for living hard tissue replacements of the present invention comprise a ceramic material which contain Cao and SiO2 as essential components, and MgO as an optional components, are substantially free from calcium phosphate and are capable of forming a compound based on calcium phosphate by contact with an aqueous solution containing phosphorus, and show high biological affinity.
Inventors
- 👤 Tohru Nonami
- 👤 Hiroyasu Noma
- 👤 Shinya Nakajima
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:25
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/10; C; C04; C04B; C04B35/00; C04B35/01; C04B35/16; C04B35/22; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
88 words
A material for living hard tissue replacement, prepared by a process comprising the steps of: coating a substrate with a layer of a ceramic material comprising CaO and SiO 2 in a weight ratio of CaO to SiO 2 of between 1:4 and 6:1, said ceramic material being substantially free from calcium phosphate and being selected from the group consisting of diopside, wollastonite, alite, belite, akermanite, monticellite, forsterite, protoenstatite and tridymite; and contacting said coated substrate with an aqueous solution containing phosphorus to form a calcium phosphate-based compound.
Claim 2
Dependent Claim
88 words
A material for living hard tissue replacement, prepared by a process comprising the steps of: coating a substrate with a layer of a ceramic material comprising CaO and SiO 2 in a weight ratio of CaO to SiO 2 of between 1:4 and 6:1, said ceramic material being substantially free from calcium phosphate and being selected from the group consisting of diopside, wollastonite, alite, belite, akermanite, monticellite, forsterite, protoenstatite and tridymite; and contacting said coated substrate with an aqueous solution containing phosphorus to form a calcium phosphate-based compound.
Claim 3
Dependent Claim
86 words
A material for living hard tissue replacement, comprising: a metal or plastic substrate; and a coat layer of a ceramic material comprising CaO and SiO 2 in a weight ratio of CaO to SiO 2 of between 1:4 and 6:1, said ceramic material being substantially free from calcium phosphate and being selected from the group consisting of diopside, wollastonite, alite, belite, akermanite, monticellite, forsterite, protoenstatite and tridymite, said ceramic material being capable of forming a calcium phosphate-based compound upon contact with an aqueous solution containing phosphorus.
Claim 4
Dependent Claim
86 words
A material for living hard tissue replacement, comprising: a metal or plastic substrate; and a coat layer of a ceramic material comprising CaO and SiO 2 in a weight ratio of CaO to SiO 2 of between 1:4 and 6:1, said ceramic material being substantially free from calcium phosphate and being selected from the group consisting of diopside, wollastonite, alite, belite, akermanite, monticellite, forsterite, protoenstatite and tridymite, said ceramic material being capable of forming a calcium phosphate-based compound upon contact with an aqueous solution containing phosphorus.
Claim 5
Dependent Claim
25 words
The material for living hard tissue replacement of claim 1 or 2, wherein said ceramic material contains from 50 to 100% by volume of diopside.
Claim 6
Dependent Claim
27 words
The material as claimed in claim 1 or 2, wherein said ceramic material contains MgO in addition to the essential components of CaO and SiO 2 .
Claim 7
Dependent Claim
35 words
The material as claimed in claim 4, wherein said ceramic material contains 10 to 88% by weight of CaO, 10 to 80% by weight of SiO 2 and 2 to 35% by weight of MgO.
Claim 8
Dependent Claim
35 words
The material as claimed in claim 5, wherein said ceramic material contains 18 to 47% by weight of CaO, 37 to 68% by weight of SiO 2 and 10 to 25% by weight of MgO.
Claim 9
Dependent Claim
23 words
The material as claimed in claim 2, wherein said ceramic material belongs to the field of diopside, wollastonite, alite, belite, akermanite or monticellite.
Claim 10
Dependent Claim
32 words
The material as claimed in claim 7, wherein said ceramic material contains at least 40% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions.
Claim 11
Dependent Claim
21 words
The material as claimed in claim 8, wherein said ceramic material contains at least 40% by volume of a diopside composition.
Claim 12
Dependent Claim
32 words
The material as claimed in claim 8, wherein said ceramic material contains at least 50% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions.
Claim 13
Dependent Claim
32 words
The material as claimed in claim 10, wherein said ceramic material contains 70% to 100% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions.
Claim 14
Dependent Claim
21 words
The material as claimed in claim 1 or 2, wherein said coat layer has a thickness of 1 to 5000 μm.
Claim 15
Dependent Claim
19 words
The material as claimed in claim 12, wherein said coat layer has a thickness of 10 to 2000 μm.
Claim 16
Dependent Claim
19 words
The material as claimed in claim 13, wherein said coat layer has a thickness of 20 to 1000 μm.
Claim 17
Dependent Claim
22 words
The material as claimed in claim 1 or 2, wherein said coat layer has a surface roughness of 1 to 200 μm.
Claim 18
Dependent Claim
20 words
The material as claimed in claim 15, wherein said coat layer has a surface roughness of 5 to 100 μm.
Claim 19
Dependent Claim
15 words
The material as claimed in claim 1 or 2, wherein said coat layer is porous.
Claim 20
Dependent Claim
21 words
The material as claimed in claim 17, wherein said porous coat layer has a pore diameter of 5 to 2000 μm.
Claim 21
Dependent Claim
21 words
The material as claimed in claim 18, wherein said porous coat layer has a pore diameter of 10 to 1000 μm.
Claim 22
Dependent Claim
19 words
The material as claimed in claim 17, wherein said porous coat layer has a porosity of 10 to 80%.
Claim 23
Dependent Claim
19 words
The material as claimed in claim 20, wherein said porous coat layer has a porosity of 20 to 70%.
Claim 24
Dependent Claim
20 words
The material as claimed in claim 21, where n said porous coat layer has a porosity of 25 to 60%.
Claim 25
Dependent Claim
16 words
The material as claimed in claim 1, wherein said substrate comprises metal, ceramic, glass or plastic.
Claim 26
Dependent Claim
50 words
The material as claimed in claim 23 or 2, wherein said substrate comprises a metal selected from the group consisting of Ti, W, Ni--Cr alloy, Fe--Cr--Al alloy, Ti--Zr alloy, Fe--Ni--Cr alloy, Mo, Ti--Al--V alloy, Co--Cr--Mo alloy, Ti--Mo alloy, Co--Cr--Ni alloy, stainless steel 304, stainless steel 310 and stainless steel 316.
Claim 27
Dependent Claim
18 words
The material as claimed in claim 23 or 2, wherein said substrate comprises Ti or an alloy thereof.
Claim 28
Dependent Claim
28 words
The material as claimed in claim 23, wherein said substrate comprises a ceramic selected from the group consisting of alumina, zirconia, silicon carbide, tungsten nitride and silicon nitride.
Claim 29
Dependent Claim
96 words
A material for living hard tissue replacement comprising a ceramic material which (i) contains CaO and SiO 2 as essential components, (ii) is substantially free from calcium phosphate and (iii) is capable of forming a compound based in calcium phosphate by contact with an aqueous solution containing phosphorous, said CaO and SiO 2 being present in a weight ratio of CaO to SiO 2 of between 1:4 and 6:1; said ceramic material being in the form of a porous body having a pore diameter of 5 to 2000 μm and a porosity of 10 to 80%.
Claim 30
Dependent Claim
96 words
A material for living hard tissue replacement comprising a ceramic material which (i) contains CaO and SiO 2 as essential components, (ii) is substantially free from calcium phosphate and (iii) is capable of forming a compound based in calcium phosphate by contact with an aqueous solution containing phosphorous, said CaO and SiO 2 being present in a weight ratio of CaO to SiO 2 of between 1:4 and 6:1; said ceramic material being in the form of a porous body having a pore diameter of 5 to 2000 μm and a porosity of 10 to 80%.
Claim 31
Dependent Claim
25 words
The material as claimed in claim 27, wherein said ceramic material contains MgO in addition to the essential components of CaO and SiO 2 .
Claim 32
Dependent Claim
35 words
The material as claimed in claim 28, wherein said ceramic material contains 10 to 88% by weight of CaO, 10 to 80% by weight of SiO 2 and 2 to 35% by weight of MgO.
Claim 33
Dependent Claim
35 words
The material as claimed in claim 29, wherein said ceramic material contains 18 to 47% by weight of CaO, 37 to 68% by weight of SiO 2 and 10 to 25% by weight of MgO.
Claim 34
Dependent Claim
23 words
The material as claimed in claim 30, wherein said ceramic material belongs to the field of diopside, wollastonite, alite, belite, akermanite or monticellite.
Claim 35
Dependent Claim
32 words
The material as claimed in claim 31, wherein said ceramic material contains at least 40% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite compositions.
Claim 36
Dependent Claim
21 words
The material as claimed in claim 32, wherein said ceramic material contains at least 40% by volume of a diopside composition.
Claim 37
Dependent Claim
32 words
The material as claimed in claim 32, wherein said ceramic material contains at least 50% by volume of a diopside composition, a wollastonite composition or a mixture of diopside and wollastonite composition.
Claim 38
Dependent Claim
35 words
The material as claimed in claim 34, wherein said ceramic material contains 70% to 100% by volume of a diopside composition, a wollastonite composition, a wollastonite composition or a mixture of diopside and wollastonite composition.
Claim 39
Dependent Claim
20 words
The material as claimed in claim 27, wherein said porous body has a pore diameter of 10 to 1000 μm.
Claim 40
Dependent Claim
18 words
The material as claimed in claim 27, wherein said porous body has a porosity of 20 to 70%.
Claim 41
Dependent Claim
18 words
The material as claimed in claim 27, wherein said porous body has a porosity of 25 to 60%.
Claim 42
Dependent Claim
27 words
The material as claimed in claim 27, wherein said porous body is in the form of granules having diameters in the range of 0.05 to 5 mm.
Claim 43
Dependent Claim
19 words
The material as claimed in claim 39, wherein said diameters are in the range of 0.1 to 3 mm.
Claim 44
Dependent Claim
19 words
The material as claimed in claim 40, wherein said diameters are in the range of 0.1 to 2 mm.
References Cited (Backward Citations)
US4073999A
Cited
US4145764A
Cited
US4146936A
Cited
US4171544A
Cited
US4352890A
Cited
EP0145210A2
Cited
EP0206726A2
Cited
EP0389713A1
Cited
US5204106A
Cited
US5125971A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-05 | 1998-03-07 | 1998-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-05 | 2002-03-07 | 2002-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-05 | 2006-03-07 | 2006-09-06 | $7700.00 | Window Closed / Lapsed |