Patent US5342940A successfully refreshed from Google Patents.
US5342940A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyethylene glycol derivatives, process for preparing the same
Assignee: Seikagaku Corp
•
Filing: 1993-09-13
•
Granted: 1994-08-30
•
Expires: 2013-09-13
Abstract
Abstract High purity polyethylene glycol derivatives of formula (I) are useful as protein modifiers of interferons, t-PA, EGF, various hormones, etc. The thus modified protein has minimized antigenicity, prolonged plasma half life, or improved transfer to tissue. A novel process for preparing high purity polyethylene glycol derivatives is also disclosed.
Inventors
- 👤 Keiichi Ono
- 👤 Yoshiyuki Kai
- 👤 Hiroo Maeda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:54
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/96; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; C07; C07D; C07D251/00; C07D251/02; C07D251/12; C07D251/26; C07K; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/333; A61K38/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
72 words
A process for preparing a polyethylene glycol derivative represented by formula (I): ##STR7## wherein R represents an alkyl group and n represents an optionally variable positive integer, which comprises reacting a polyethylene glycol mono-alkyl ether compound represented by the formula (II): R--(OCH.sub.2 CH.sub.2).sub.n --OH (II) wherein R and n have the same significances as described above, with cyanuric chloride in the presence of an oxide of a metal belonging to Group IIB.
Claim 2
Dependent Claim
72 words
A process for preparing a polyethylene glycol derivative represented by formula (I): ##STR7## wherein R represents an alkyl group and n represents an optionally variable positive integer, which comprises reacting a polyethylene glycol mono-alkyl ether compound represented by the formula (II): R--(OCH.sub.2 CH.sub.2).sub.n --OH (II) wherein R and n have the same significances as described above, with cyanuric chloride in the presence of an oxide of a metal belonging to Group IIB.
Claim 3
Dependent Claim
24 words
A process according to claim 1, wherein said metal oxide is selected from the group consisting of zinc oxide, cadmium oxide and mercury oxide.
References Cited (Backward Citations)
US4179337A
Cited
JPS5623587A
Cited
EP0149520A2
Cited
JPS61178926A
Cited
JPS6142558A
Cited
EP0210761A1
Cited
JPS62115280A
Cited
JPS62175175A
Cited
JPS6310800A
Cited
JPH01316400A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-29 | 1998-02-28 | 1998-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-29 | 2002-02-28 | 2002-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-29 | 2006-02-28 | 2006-08-30 | $7700.00 | Window Closed / Lapsed |