US5342940A
Expired / Lapsed
US
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Polyethylene glycol derivatives, process for preparing the same
Assignee: Seikagaku Corp
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Filing: 1993-09-13
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Granted: 1994-08-30
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Expires: 2013-09-13
Abstract
Abstract High purity polyethylene glycol derivatives of formula (I) are useful as protein modifiers of interferons, t-PA, EGF, various hormones, etc. The thus modified protein has minimized antigenicity, prolonged plasma half life, or improved transfer to tissue. A novel process for preparing high purity polyethylene glycol derivatives is also disclosed.
Inventors
- 👤 Keiichi Ono
- 👤 Yoshiyuki Kai
- 👤 Hiroo Maeda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:53
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/96; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; C07; C07D; C07D251/00; C07D251/02; C07D251/12; C07D251/26; C07K; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/333; A61K38/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
72 words
A process for preparing a polyethylene glycol derivative represented by formula (I): ##STR7## wherein R represents an alkyl group and n represents an optionally variable positive integer, which comprises reacting a polyethylene glycol mono-alkyl ether compound represented by the formula (II): R--(OCH.sub.2 CH.sub.2).sub.n --OH (II) wherein R and n have the same significances as described above, with cyanuric chloride in the presence of an oxide of a metal belonging to Group IIB.
Claim 2
Dependent Claim
72 words
A process for preparing a polyethylene glycol derivative represented by formula (I): ##STR7## wherein R represents an alkyl group and n represents an optionally variable positive integer, which comprises reacting a polyethylene glycol mono-alkyl ether compound represented by the formula (II): R--(OCH.sub.2 CH.sub.2).sub.n --OH (II) wherein R and n have the same significances as described above, with cyanuric chloride in the presence of an oxide of a metal belonging to Group IIB.
Claim 3
Dependent Claim
24 words
A process according to claim 1, wherein said metal oxide is selected from the group consisting of zinc oxide, cadmium oxide and mercury oxide.
References Cited (Backward Citations)
US4179337A
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JPS5623587A
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EP0149520A2
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JPS61178926A
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JPS6142558A
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EP0210761A1
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JPS62115280A
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JPS62175175A
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JPS6310800A
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JPH01316400A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-29 | 1998-02-28 | 1998-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-29 | 2002-02-28 | 2002-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-29 | 2006-02-28 | 2006-08-30 | $7700.00 | Window Closed / Lapsed |