US5340361A — Implantable pacemaker having adaptive AV interval…

Claim 1

Independent Claim 338 words

A dual-chamber pacemaker providing atrioventricular pacing in order to increase cardiac output in a patient suffering from a cardiomyopathy, comprising: an atrial channel and a ventricular channel; an atrial sense amplifier that senses a P-wave in the atrial channel, said P-wave representing natural atrial activity; a ventricular sense amplifier that senses an R-wave in the ventricular channel, said R-wave representing natural ventricular activity; pulse generator means for generating an atrial stimulation pulse (A-pulse) in the atrial channel in the absence of a sensed P-wave by said atrial sense amplifier within an atrial escape interval, and a ventricular stimulation pulse (V-Pulse) in the ventricular channel in the absence of a sensed R-wave by said ventricular sense amplifier within an AV time interval; a control system that defines said AV time interval and said atrial escape interval, said AV time interval beginning upon the sensing of a P-wave or the generation of an A-pulse, whichever event occurs first in the atrial channel, and said atrial escape interval beginning upon the sensing of an R-wave or the generation of a V-pulse, whichever event occurs first in the ventricular channel; and timing means as part of said control system for measuring a conduction time interval as the time period between atrial activity in the atrial channel and the sensing of an R-wave in the ventricular channel, and for automatically setting said AV time interval to a value that for ventricular pacing is always less than the measured conduction time interval by a prescribed amount, said atrial activity comprising the generation of an A-pulse or the sensing of a P-wave, whichever event occurs first, in the atrial channel; whereby, in the absence of a decreasing conduction time interval, said pulse generator means generates said V-pulse in the ventricular channel prior to the occurrence of an R-wave, thereby providing ventricular pacing for increasing cardiac output; and further whereby, in the presence of a decreasing conduction time interval, said AV time interval is automatically adjusted to a value less than the shortest conduction time interval.

Claim 2

Dependent Claim 338 words

A dual-chamber pacemaker providing atrioventricular pacing in order to increase cardiac output in a patient suffering from a cardiomyopathy, comprising: an atrial channel and a ventricular channel; an atrial sense amplifier that senses a P-wave in the atrial channel, said P-wave representing natural atrial activity; a ventricular sense amplifier that senses an R-wave in the ventricular channel, said R-wave representing natural ventricular activity; pulse generator means for generating an atrial stimulation pulse (A-pulse) in the atrial channel in the absence of a sensed P-wave by said atrial sense amplifier within an atrial escape interval, and a ventricular stimulation pulse (V-Pulse) in the ventricular channel in the absence of a sensed R-wave by said ventricular sense amplifier within an AV time interval; a control system that defines said AV time interval and said atrial escape interval, said AV time interval beginning upon the sensing of a P-wave or the generation of an A-pulse, whichever event occurs first in the atrial channel, and said atrial escape interval beginning upon the sensing of an R-wave or the generation of a V-pulse, whichever event occurs first in the ventricular channel; and timing means as part of said control system for measuring a conduction time interval as the time period between atrial activity in the atrial channel and the sensing of an R-wave in the ventricular channel, and for automatically setting said AV time interval to a value that for ventricular pacing is always less than the measured conduction time interval by a prescribed amount, said atrial activity comprising the generation of an A-pulse or the sensing of a P-wave, whichever event occurs first, in the atrial channel; whereby, in the absence of a decreasing conduction time interval, said pulse generator means generates said V-pulse in the ventricular channel prior to the occurrence of an R-wave, thereby providing ventricular pacing for increasing cardiac output; and further whereby, in the presence of a decreasing conduction time interval, said AV time interval is automatically adjusted to a value less than the shortest conduction time interval.

Claim 3

Dependent Claim 98 words

The dual-chamber pacemaker, as set forth in claim 1, wherein said timing means of said control system further automatically increases said AV time interval by a prescribed amount in the event a prescribed number of consecutive cardiac cycles occur without an R-wave being sensed by said ventricular sense amplifier; a cardiac cycle comprising the time period between consecutive atrial activity, whereby said AV time interval does not remain adjusted to a value less than the shortest conduction time interval in the absence of sensed R-waves for a period of time longer than said prescribed number of cardiac cycles.

Claim 4

Dependent Claim 62 words

The dual-chamber pacemaker, as set forth in claim 2, further comprising a memory circuit coupled to said control system, said memory circuit having prescribed minimum and maximum AV interval values stored therein, said minimum and maximum AV interval values being usable by said control system to limit the adjustment of said AV time interval between said minimum and maximum AV interval values.

Claim 5

Dependent Claim 50 words

The dual-chamber pacemaker, as set forth in claim 3, wherein said control system comprises a state logic circuit that changes states in response to the occurrence of prescribed events, said prescribed events including the timing-out of specified time intervals, and the sensing of activity in the atrial or ventricular channels.

Claim 6

Dependent Claim 96 words

The dual-chamber pacemaker, as set forth in claim 3, wherein said control system comprises a programmable timer circuit and a clock circuit, said programmable timer circuit having a time interval value loaded therein, said clock circuit generating a clock signal that counts said programmable timer circuit for the number of counts represented by said time interval value, whereupon said programmable timer circuit issues a time-out signal; said time interval value being adaptively changed by logic circuits within said control system to represent the AV time interval, whereby said programmable timer circuit defines said AV time interval.

Claim 7

Dependent Claim 204 words

A dual-chamber implantable pacemaker programmed to operate in a DDD or DDDR mode of operation so as to generate a ventricular stimulation pulse (V-pulse) during a given cardiac cycle prior to natural ventricular activity, yet at a time delayed sufficiently from any preceding atrial activity to assure efficient cardiac output, said pacemaker comprising: sensing means for sensing P-waves and R-waves; stimulation means for generating V-pulses and A-pulses; measurement means for measuring the natural conduction time, t PR , or t AR , of a heart to which the pacemaker is coupled, where t PR represents the natural conduction time following a natural atrial event (P-wave), and t AR represents the natural conduction time of the heart following an atrial stimulation pulse (A-pulse); and timing means for automatically setting a PV interval for use by said pacemaker following a P-wave, and an AV interval for use by said pacemaker following an A-pulse, to a prescribed amount less than said natural conduction time, t PR or t AR , respectively, said PV and AV intervals being used by said timing means to define the time period between a P-wave and a V-pulse, and between an A-pulse and a V-pulse, respectively, during the operation of said pacemaker.

Claim 8

Dependent Claim 204 words

A dual-chamber implantable pacemaker programmed to operate in a DDD or DDDR mode of operation so as to generate a ventricular stimulation pulse (V-pulse) during a given cardiac cycle prior to natural ventricular activity, yet at a time delayed sufficiently from any preceding atrial activity to assure efficient cardiac output, said pacemaker comprising: sensing means for sensing P-waves and R-waves; stimulation means for generating V-pulses and A-pulses; measurement means for measuring the natural conduction time, t PR , or t AR , of a heart to which the pacemaker is coupled, where t PR represents the natural conduction time following a natural atrial event (P-wave), and t AR represents the natural conduction time of the heart following an atrial stimulation pulse (A-pulse); and timing means for automatically setting a PV interval for use by said pacemaker following a P-wave, and an AV interval for use by said pacemaker following an A-pulse, to a prescribed amount less than said natural conduction time, t PR or t AR , respectively, said PV and AV intervals being used by said timing means to define the time period between a P-wave and a V-pulse, and between an A-pulse and a V-pulse, respectively, during the operation of said pacemaker.

Claim 9

Dependent Claim 57 words

The dual-chamber implantable pacemaker, as set forth in claim 6, wherein said timing means automatically adjusts said PV and AV intervals to make them a prescribed amount less than the PV or AV interval used by said pacemaker in a most recent cardiac cycle in the event an R-wave is sensed during said most recent pacing cycle.

Claim 10

Dependent Claim 70 words

The dual-chamber implantable pacemaker, as set forth in claim 7, wherein said timing means further automatically adjusts said PV and AV intervals to make them a prescribed amount greater than the PV or AV interval used by said pacemaker in a most recent cardiac cycle, up to a predetermined maximum PV or AV interval, in the event no R-wave is sensed for a specified number of consecutive prior cardiac cycles.

Claim 11

Dependent Claim 70 words

The dual-chamber implantable pacemaker, as set forth in claim 6, wherein said measurement means includes means for measuring one of said t PR or t AR natural conduction times, depending upon which of said A-pulse or P-wave occurs first, and computing the other of said t PR or t AR natural conduction times as a function of said measured one of said t PR or t AR natural conduction times.

Claim 12

Dependent Claim 98 words

The dual-chamber implantable pacemaker, as set forth in claim 9, wherein said means for computing the other of said t PR or t AR natural conduction times once one has been measured comprises means for defining t AR to be a prescribed amount greater than t PR , whereby once one of said t PR or t AR natural conduction times has been measured, the other of said t PR or t AR natural conduction times is computed to be less than or greater than the measured value of t PR or t AR by said prescribed amount.

Claim 13

Dependent Claim 63 words

The dual-chamber implantable pacemaker, as set forth in claim 6, wherein said measurement means includes means for measuring both t PR and t AR , where t PR is measured as the time interval between the occurrence of a P-wave and a subsequent R-wave, and t AR is measured as the time interval between the generation of an A-pulse and a subsequent R-wave.

Claim 14

Dependent Claim 45 words

The dual-chamber implantable pacemaker, as set forth in claim 6, wherein said timing means sets the PV interval to be a first prescribed amount less than t PR , and sets the AV interval to be a second prescribed amount less than t AR .

Claim 15

Dependent Claim 47 words

The dual-chamber implantable pacemaker, as set forth in claim 12, wherein said first prescribed amount is the same as said second prescribed amount, whereby the difference between said PV interval and said AV interval is the same as the difference between t AR and t PR .

Claim 16

Dependent Claim 39 words

The dual-chamber implantable pacemaker, as set forth in claim 12, wherein said first prescribed amount and said second prescribed amount are computed as a function of the most recent measured values of t PR and t AR , respectively.

Claim 17

Dependent Claim 148 words

A dual chamber pacemaker comprising: means for sensing and pacing in both an atrial and ventricular channel; timing means for setting an AV interval, said AV interval comprising the maximum time period allowed by the pacemaker between atrial channel activity, which atrial channel activity includes sensing or pacing in the atrial channel, and pacing in the ventricular channel; measurement means for measuring a first time interval as the time interval between atrial channel activity and sensing in the ventricular channel; adjustment means for automatically setting the AV interval of said pacemaker to a value that for pacing in the ventricular channel is always less than the most recently measured first time interval; and control means for pacing in the ventricular channel at the conclusion of said AV interval in the event that no sensing occurs in the ventricular channel during said AV interval, whereby ventricular pacing is provided.

Claim 18

Dependent Claim 148 words

A dual chamber pacemaker comprising: means for sensing and pacing in both an atrial and ventricular channel; timing means for setting an AV interval, said AV interval comprising the maximum time period allowed by the pacemaker between atrial channel activity, which atrial channel activity includes sensing or pacing in the atrial channel, and pacing in the ventricular channel; measurement means for measuring a first time interval as the time interval between atrial channel activity and sensing in the ventricular channel; adjustment means for automatically setting the AV interval of said pacemaker to a value that for pacing in the ventricular channel is always less than the most recently measured first time interval; and control means for pacing in the ventricular channel at the conclusion of said AV interval in the event that no sensing occurs in the ventricular channel during said AV interval, whereby ventricular pacing is provided.

Claim 19

Dependent Claim 27 words

The dual-chamber pacemaker, as set forth in claim 15, wherein said measurement means measures said first time interval each time that sensing occurs in the ventricular channel.

Claim 20

Dependent Claim 59 words

The dual-chamber pacemaker, as set forth in claim 15, wherein said adjustment means also increases said AV interval by a specified amount in the event that no sensing occurs in the ventricular channel for a prescribed number of cardiac cycles, where a cardiac cycle comprises the consecutive occurrence of atrial channel activity followed by pacing in the ventricular channel.

Claim 21

Independent Claim 232 words

A method of operating a dual-chamber implantable pacemaker to provide ventricular stimulation pulses at a time within a cardiac cycle that is just prior to when a natural ventricular contraction would occur, said implantable pacemaker including means for sensing natural atrial contractions (P-waves), means for sensing natural ventricular contractions (R-waves), means for generating atrial stimulation pulses (A-pulses), means for generating ventricular stimulation pulses (V-pulses), and timing means for defining an AV interval that commences with the generation of an A-pulse, and a PV interval that commences with the sensing of a P-wave, said method comprising: (a) electronically measuring a first time interval within a given cardiac cycle that comprises the time between an atrial event and an R-wave, said atrial event comprising either an A-pulse or a P-wave, whichever event occurs first in the given cardiac cycle; (b) automatically setting said AV interval to be equal to said first time interval less a first prescribed amount; (c) automatically setting said PV interval to be equal to said first time interval less a second prescribed amount; and (d) issuing a V-pulse at the conclusion of said AV interval, in the event an A-pulse has first been generated, or at the conclusion of said PV interval, in the event a P-wave has first been sensed; whereby said V-pulse is always generated at the conclusion of said AV or PV interval following said atrial event.

Claim 22

Independent Claim 232 words

A method of operating a dual-chamber implantable pacemaker to provide ventricular stimulation pulses at a time within a cardiac cycle that is just prior to when a natural ventricular contraction would occur, said implantable pacemaker including means for sensing natural atrial contractions (P-waves), means for sensing natural ventricular contractions (R-waves), means for generating atrial stimulation pulses (A-pulses), means for generating ventricular stimulation pulses (V-pulses), and timing means for defining an AV interval that commences with the generation of an A-pulse, and a PV interval that commences with the sensing of a P-wave, said method comprising: (a) electronically measuring a first time interval within a given cardiac cycle that comprises the time between an atrial event and an R-wave, said atrial event comprising either an A-pulse or a P-wave, whichever event occurs first in the given cardiac cycle; (b) automatically setting said AV interval to be equal to said first time interval less a first prescribed amount; (c) automatically setting said PV interval to be equal to said first time interval less a second prescribed amount; and (d) issuing a V-pulse at the conclusion of said AV interval, in the event an A-pulse has first been generated, or at the conclusion of said PV interval, in the event a P-wave has first been sensed; whereby said V-pulse is always generated at the conclusion of said AV or PV interval following said atrial event.

Claim 23

Dependent Claim 42 words

The method, as set forth in claim 18, wherein steps (a) to (c) are performed periodically at a prescribed interval, and step (d) is performed every cardiac cycle using the most recent AV or PV interval set by steps (b) and (c).

Claim 24

Dependent Claim 33 words

The method, as set forth in claim 19, wherein the prescribed interval at which steps (a)-(c) are performed comprises an interval defined by the occurrence of a programmed number of consecutive cardiac cycles.

Claim 25

Dependent Claim 24 words

The method, as set forth in claim 18, wherein steps (a) to (c) are performed during each cardiac cycle in which an R-wave occurs.

Claim 26

Dependent Claim 46 words

The method, as set forth in claim 21, further including increasing said AV and PV intervals by a third prescribed amount up to a maximum AV and PV interval in the event a predetermined number of consecutive cardiac cycles occurs without the occurrence of an R-wave.

Claim 27

Dependent Claim 304 words

In a dual-chamber implantable pacemaker programmed to operate in a DDD or DDDR mode of operation, a method of operating said pacemaker when coupled to a heart of a patient so as to generate a ventricular stimulation pulse (V-pulse) during a given cardiac cycle prior to natural ventricular activity, yet at a time delayed sufficiently from any preceding atrial activity to assure efficient cardiac output, said pacemaker including means for sensing P-waves and R-waves, and means for generating V-pulses and A-pulses, said method comprising the steps of: (a) determining the natural conduction time of the heart, t PR or t AR , where t PR represents the natural conduction time following a natural atrial event (P-wave), and t AR represents the natural conduction time of the heart following an atrial stimulation pulse (A-pulse); (b) automatically setting a PV interval, for use by said pacemaker following a P-wave, and an AV interval, for use by said pacemaker following an A-pulse, to a prescribed amount less than said natural conduction time, t PR or t AR , respectively; (c) performing at least one pacing cycle in said DDD or DDDR mode of operation using the PV and AV intervals to define the time period between an atrial event and the generation of a V-pulse; (d) automatically adjusting said PV and AV intervals to make them a prescribed amount less than the PV or AV interval used most recently by said pacemaker in the event an R-wave is sensed during said at least one pacing cycle; and (e) automatically adjusting said PV and AV intervals to make them a prescribed amount greater than the PV or AV interval used most recently by said pacemaker, up to a predetermined maximum PV or AV interval, in the event no R-wave is sensed for a specified number of cardiac cycles.

Claim 28

Dependent Claim 304 words

In a dual-chamber implantable pacemaker programmed to operate in a DDD or DDDR mode of operation, a method of operating said pacemaker when coupled to a heart of a patient so as to generate a ventricular stimulation pulse (V-pulse) during a given cardiac cycle prior to natural ventricular activity, yet at a time delayed sufficiently from any preceding atrial activity to assure efficient cardiac output, said pacemaker including means for sensing P-waves and R-waves, and means for generating V-pulses and A-pulses, said method comprising the steps of: (a) determining the natural conduction time of the heart, t PR or t AR , where t PR represents the natural conduction time following a natural atrial event (P-wave), and t AR represents the natural conduction time of the heart following an atrial stimulation pulse (A-pulse); (b) automatically setting a PV interval, for use by said pacemaker following a P-wave, and an AV interval, for use by said pacemaker following an A-pulse, to a prescribed amount less than said natural conduction time, t PR or t AR , respectively; (c) performing at least one pacing cycle in said DDD or DDDR mode of operation using the PV and AV intervals to define the time period between an atrial event and the generation of a V-pulse; (d) automatically adjusting said PV and AV intervals to make them a prescribed amount less than the PV or AV interval used most recently by said pacemaker in the event an R-wave is sensed during said at least one pacing cycle; and (e) automatically adjusting said PV and AV intervals to make them a prescribed amount greater than the PV or AV interval used most recently by said pacemaker, up to a predetermined maximum PV or AV interval, in the event no R-wave is sensed for a specified number of cardiac cycles.

Claim 29

Dependent Claim 65 words

The method, as set forth in claim 23, wherein step (a) comprises measuring one of said t PR or t AR natural conduction times, depending upon which of said A-pulse or P-wave occurs first, and computing the other of said t PR or t AR natural conduction times as a function of said measured one of said t PR or t AR natural conduction times.

Claim 30

Dependent Claim 91 words

The method, as set forth in claim 24, wherein computing the other of said t PR or t AR natural conduction times once one has been measured comprises defining t AR to be a prescribed amount greater than t PR , whereby once one of said t PR or t AR natural conduction times has been measured, the other of said t PR or t AR natural conduction times is computed to be less than or greater than the measured value of t PR or t AR by said prescribed amount.

Claim 31

Dependent Claim 58 words

The method, as set forth in claim 23, wherein step (a) comprises measuring both t PR and t AR , where t PR is measured as the time interval between the occurrence of a P-wave and a subsequent R-wave, and t AR is measured as the time interval between the generation of an A-pulse and a subsequent R-wave.

Claim 32

Dependent Claim 43 words

The method, as set forth in claim 23, wherein step (b) comprises setting the PV interval to be a first prescribed amount less than t PR , and setting the AV interval to be a second prescribed amount less than t AR .

Claim 33

Dependent Claim 45 words

The method, as set forth in claim 27, wherein said first prescribed amount is the same as said second prescribed amount, whereby the difference between said PV interval and said AV interval is the same as the difference between t AR and t PR .

Claim 34

Dependent Claim 37 words

The method, as set forth in claim 27, wherein said first prescribed amount and said second prescribed amount are computed as a function of the most recent measured values of t PR and t AR , respectively.

Claim 35

Independent Claim 144 words

A method of providing ventricular pacing in order to increase cardiac output in a cardiomyopathy patient, such patient having a dual-chamber pacemaker, said pacemaker including means for sensing and pacing in both an atrial and ventricular channel, and timing means for setting an AV interval, said method comprising the steps of: (a) measuring a first time interval as the time interval between atrial channel activity and sensing in the ventricular channel for determining a natural conduction time, said atrial channel activity comprising sensing or pacing in the atrial channel; (b) automatically setting the AV interval of said pacemaker to a value that is a prescribed amount less than the natural conduction time, where said AV interval defines the time interval between atrial channel activity and pacing in the ventricular channel; and (c) pacing in the ventricular channel at the conclusion of said AV interval.

Claim 36

Independent Claim 144 words

A method of providing ventricular pacing in order to increase cardiac output in a cardiomyopathy patient, such patient having a dual-chamber pacemaker, said pacemaker including means for sensing and pacing in both an atrial and ventricular channel, and timing means for setting an AV interval, said method comprising the steps of: (a) measuring a first time interval as the time interval between atrial channel activity and sensing in the ventricular channel for determining a natural conduction time, said atrial channel activity comprising sensing or pacing in the atrial channel; (b) automatically setting the AV interval of said pacemaker to a value that is a prescribed amount less than the natural conduction time, where said AV interval defines the time interval between atrial channel activity and pacing in the ventricular channel; and (c) pacing in the ventricular channel at the conclusion of said AV interval.

Claim 37

Dependent Claim 58 words

The method, as set forth in claim 30, further comprising the step of: (d) adjusting said AV interval to a value that is said prescribed amount less than the time interval between the most recent atrial channel activity and sensing in the ventricular channel in the event that sensing occurs in the ventricular channel during said AV interval.

Claim 38

Dependent Claim 59 words

The method, as set forth in claim 31, further comprising the step of: (e) increasing said AV interval by a specified amount in the event that no sensing occurs in the ventricular channel for a prescribed number of cardiac cycles, where a cardiac cycle comprises the consecutive occurrence of atrial channel activity followed by pacing in the ventricular channel.

Claim 39

Dependent Claim 203 words

A dual-chamber pacemaker for controlling ventricular pacing in order to increase cardiac output in a patient suffering from a cardiomyopathy by preemptively stimulating the ventricular channel comprising: an atrial channel and a ventricular channel; an atrial sense amplifier that senses a P-wave in the atrial channel, said P-wave representing natural atrial activity; a ventricular sense amplifier that senses an R-wave in the ventricular channel, said R-wave representing natural ventricular activity; pulse generator means for generating a ventricular stimulation pulse (V-Pulse) in the ventricular channel and an atrial stimulation pulse (A-pulse) in the atrial channel, the sensing of a P-wave or the generating of an A-pulse, whichever occurs first, comprising atrial activity; and timing means for defining an AV time interval as the time interval between atrial activity and the generation of a V-pulse, said timing means further for measuring a natural conduction time interval as the time period between atrial activity and the sensing of an R-wave, and for automatically setting said AV time interval to a value that is less than said natural conduction time interval, whereby said pulse generator generates said V-pulse prior to the occurrence of natural ventricular activity for preemptively stimulating the ventricular channel to thereby increase cardiac output.

Claim 40

Dependent Claim 203 words

A dual-chamber pacemaker for controlling ventricular pacing in order to increase cardiac output in a patient suffering from a cardiomyopathy by preemptively stimulating the ventricular channel comprising: an atrial channel and a ventricular channel; an atrial sense amplifier that senses a P-wave in the atrial channel, said P-wave representing natural atrial activity; a ventricular sense amplifier that senses an R-wave in the ventricular channel, said R-wave representing natural ventricular activity; pulse generator means for generating a ventricular stimulation pulse (V-Pulse) in the ventricular channel and an atrial stimulation pulse (A-pulse) in the atrial channel, the sensing of a P-wave or the generating of an A-pulse, whichever occurs first, comprising atrial activity; and timing means for defining an AV time interval as the time interval between atrial activity and the generation of a V-pulse, said timing means further for measuring a natural conduction time interval as the time period between atrial activity and the sensing of an R-wave, and for automatically setting said AV time interval to a value that is less than said natural conduction time interval, whereby said pulse generator generates said V-pulse prior to the occurrence of natural ventricular activity for preemptively stimulating the ventricular channel to thereby increase cardiac output.

Claim 41

Dependent Claim 34 words

The dual-chamber pacemaker of claim 33, further comprising means for setting the AV interval to a value that, for ventricular pacing, is always less than the natural conduction time interval by a prescribed amount.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1997-08-22	1998-02-21	1998-08-23	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2001-08-22	2002-02-21	2002-08-23	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2005-08-22	2006-02-21	2006-08-23	$7700.00	Window Closed / Lapsed

Implantable pacemaker having adaptive AV interval adoptively shortened to assure ventricular pacing

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