Abstract A bone cement composition has adjustable rheological properties, high strength, and produces a uniform radiological image. The cement comprises beads containing a polymerization initiator in controllable concentrations from 0% to 5% or more by weight. These same beads or others may also contain an opacifier. The polymerization initiator and the opacifier may be selectively distributed throughout the beads or at specific radial locations in the beads or within the beads in specific strata. They may also be selectively placed in beads of a particular advantageous size range. Furthermore, in other embodiments of the invention, other advantageous additives can be incorporated in the beads such as dyes, antibiotics, bone growth factors, and other pharmacological or therapeutic agents.
A method of manufacturing beads for incorporation into the dry component of a bone cement comprising the steps of: (a) forming a first opacifier containing bead by solidifying a first liquid comprising a liquified polymer combined with an opacifier; (b) coating the first bead to form a second, layered bead by coating the first bead with a second liquid comprising a liquified polymer combined with a polymerization initiator and solidifying the coating.
Claim 2
Independent Claim
72 words
A method of manufacturing beads for incorporation into the dry component of a bone cement comprising the steps of: (a) forming a first opacifier containing bead by solidifying a first liquid comprising a liquified polymer combined with an opacifier; (b) coating the first bead to form a second, layered bead by coating the first bead with a second liquid comprising a liquified polymer combined with a polymerization initiator and solidifying the coating.