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Patent US5314688A successfully refreshed from Google Patents.
US5314688A
Expired / Lapsed
US
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Local delivery of dipyridamole for the treatment of proliferative diseases
Assignee: Eli Lilly and Co
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Filing: 1993-02-09
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Granted: 1994-05-24
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Expires: 2013-02-09
Abstract
Abstract A method of inhibiting cell proliferation in mammals which comprises the local delivery of an inhibitory amount of dipyridamole. Inhibiting cell proliferation is useful for the treatment of proliferative diseases such as vascular restonesis, scleroderma, psoriasis, and rheumatoid arthritis. This method includes the local delivery of dipyridamole to the proliferative site by various techniques including local delivery catheters, site specific carriers, implants, direct injection, or direct application.
Inventors
- 👤 Raymond F. Kauffman
- 👤 Jai P. Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61P; A61P29/00; A61P35/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
44 words
A method of inhibiting cell proliferation in mammals in need thereof, which comprises the local delivery of a therapeutic amount of dipyridamole sufficient to inhibit cell proliferation wherein the local delivery is by a local delivery catheter, a site specific carrier, or an implant.
Claim 2
Independent Claim
44 words
A method of inhibiting cell proliferation in mammals in need thereof, which comprises the local delivery of a therapeutic amount of dipyridamole sufficient to inhibit cell proliferation wherein the local delivery is by a local delivery catheter, a site specific carrier, or an implant.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the cells inhibited are vascular smooth muscles cells.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the cells inhibited are fibroblast.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the cells inhibited are mesenchymal.
Claim 6
Dependent Claim
11 words
The method of claim 2 wherein the implant is a stent.
Claim 7
Dependent Claim
18 words
The method of claim 2 wherein the implant is a microparticle having a diameter less than 10 um.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-05-23 | 1997-11-22 | 1998-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-05-23 | 2001-11-22 | 2002-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-05-23 | 2005-11-22 | 2006-05-24 | $7700.00 | Window Closed / Lapsed |