Electroencephalograph instrument for mass screening

Claim 2

An electroencephalographic (EEG) system comprising: (a) a plurality of EEG electrodes, including a fiducial electrode, adapted to be removably secured to the scalp of the patient, each EEG electrode being a portion of a brain wave signal channel; (b) an amplifier means to amplify the analog microvolt level brain wave signals from the EEG electrodes in each brain wave channel, the amplifier means consisting of a plurality of fewer amplifiers than two-thirds the number of the EEG electrodes; (c) electronic switching means to sample the larger number of electrodes by the smaller number of amplifiers; (d) an analog/digital converter connected to the amplifiers to produce therefrom EEG data consisting of amplified and digitized brain wave signals; (e) a micro-processor based computer system means connected to the analog/digital converter to analyze the EEG data; (f) a patient stimulator means connected to and controlled by the computer system means to provide a selected pattern of stimulation to the patient to evoke the patient's brain wave responses in a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; g) a computer memory means connected to the computer system means to store the test scores of normal groups to a set of evoked potential tests corresponding to the evoked potential tests given to the patient; (h) test score pair comparison means in the computer system means to form at least 24 pairs of test scores, each pair comprising two test scores from duplicated tests; to compare one test score of each pair with the other test score of the same pair, and to accept for further analysis only those pairs in which the two test scores of the pair are sufficiently alike within a predetermined definition; (i) normal comparison means in the computer system to compare accepted pairs of test scores with the normal group test scores of (g) and to identify, as being abnormal, those accepted pairs of test sources which are significantly deviant from the normal group test scores of (g); (j) signal means to signal the finding by (i) of abnormal test scores of the patient.

Claim 3

A system as in claim 1 wherein the test score pair comparison means of (h) arranges the test scores of each pair into respective odd and even matrices, each matrix consisting of rows and columns of test scores with the test scores of each pair being at corresponding locations in each matrix.

Claim 4

A system as in claim 1 wherein in (h) there are at least 48 pairs of the test scores.

Claim 5

A system as in claim 1 and including an EOG electrode adapted to be removably positioned proximate an eye of the patient to detect blinking, the EOG electrode being part of an EOG channel.

Claim 6

A system as in claim 4 and including means in the computer system of (e) to quantify the EEG data by spectral analysis using FFT (Fast Fourier Transform) and to detect artifact by regressing out the EOG channel from every EEG channel by comparison of the EOG channel and each EEG channel and to reject any intervals in which the voltage exceeds a multiple of the r m s voltage equal to 6×the standard deviation of means amplitude.

Claim 7

A system as in claim 1 and including mean feature means in the computer system of (e) to analyze the EEG data separately in the delta, theta, alpha and beta bands of brain wave frequencies and separately in each of the bands for each of the features of absolute power, relative power coherence and symmetry for each of the EEG channels and for homologous pairs of EEG channels to provide a set of mean feature values.

Claim 8

A system as in claim 6 and including correction means in the computer system of (e) to correct the mean feature values for Gaussianity.

Claim 9

A system as in claim 6 and including means to store age regression equations and to correct the mean feature values according to the age of the patient using the stored age-regression equations.

Claim 10

A system as in claim 1 including software means to join EEG data, meeting a predetermined definition of being artifact-free, into a continuous artifact-free record and to slice the joined artifact-free record into at least 48 segments each of at least 1 second in duration.

Claim 12

A system as in claim 1 wherein the computer system of (e) includes means to analyze the EEG data signals by average response computation.

Claim 13

A system as in claim 1 and further comprising a display means connected to the computer system to display the analog brain waves amplified by the amplifiers.

Claim 14

A system as in claim 1 wherein the significantly deviant level of (h) is defined to be at the P<0.01 level.

Claim 15

An electroencephalographic (EEG) system comprising: (a) a plurality of EEG electrodes adapted to be removably secured to the scalp of a patient, including a fiducial electrode, each EEG electrode being a portion of a brain wave signal channel; (b) an amplifier means to amplify the analog microvolt level brain wave signals form the EEG electrodes in each channel, the amplifier means consisting of a plurality of amplifiers which are fewer amplifiers than two-thirds the number of electrodes; (c) switching means to sample the larger number of EEG electrodes by the smaller number of amplifiers; (d) an analog/digital converter connected to the amplifiers to produce therefrom EEG data consisting of amplified and digitized brain wave signals; (e) a micro-processor based computer system connected to the analog/digital converter to analyze the EEG data; (f) a patient stimulator means connected to and controlled by the computer system to provide a selected pattern of stimulation to the patient to evoke the patient's brain wave responses in a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; (g) a computer memory means connected to the computer system to store the test scores of normal groups to a set of evoked potential tests corresponding to the evoked potential tests given to the patient; (h) an EOG (electro-oculogram) electrode adapted to be removably attached to the patient's skin proximate the patient's eye and EOG amplification means to amplify the signals from the EOG electrode, the EOG amplification means connected to the analog/digital converter and the EOG electrode and EOG amplification means constituting an EOG channel; (i) quantification means in the computer system of (e) to quantify the EEG data by spectral analysis using FFT (Fast Fourier Transform) and to detect artifact by regressing out the EOG channel from every EEG channel by comparison of the EOG channel and each EEG channel; and to reject any of the intervals in which the voltage exceeds a multiple of the r m s voltage equal to 6×the standard deviation of means amplitude; (j) test score pair comparison means in the computer system to form at least 24 pairs of test scores, each pair comprising two test scores from duplicated tests, to compare one test score of each pair with the other test score of the same pair to arrange the test scores of each pair into respective odd and even matrices each matrix consisting of rows and columns of test scores with the test scores of each pair being at the corresponding location in each matrix; and to accept for further analysis only those pairs in which the two test scores of the pair are sufficiently alike within a predetermined definition; (k) normal comparison means in the computer system to compare accepted pairs of test scores with the normal group test scores of (g) and to identify, as being abnormal, those accepted pairs of test scores which are significantly deviant from the normal group test scores of (g); and (1) signal means to signal the finding by (k) of abnormal test scores of the patient.

Claim 16

An electroencephalographic (EEG) system comprising: (a) a plurality of EEG electrodes adapted to be removably secured to the scalp of a patient, including a fiducial electrode, each EEG electrode being a portion of a brain wave signal channel; (b) an amplifier means to amplify the analog microvolt level brain wave signals form the EEG electrodes in each channel, the amplifier means consisting of a plurality of amplifiers which are fewer amplifiers than two-thirds the number of electrodes; (c) switching means to sample the larger number of EEG electrodes by the smaller number of amplifiers; (d) an analog/digital converter connected to the amplifiers to produce therefrom EEG data consisting of amplified and digitized brain wave signals; (e) a micro-processor based computer system connected to the analog/digital converter to analyze the EEG data; (f) a patient stimulator means connected to and controlled by the computer system to provide a selected pattern of stimulation to the patient to evoke the patient's brain wave responses in a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; (g) a computer memory means connected to the computer system to store the test scores of normal groups to a set of evoked potential tests corresponding to the evoked potential tests given to the patient; (h) an EOG (electro-oculogram) electrode adapted to be removably attached to the patient's skin proximate the patient's eye and EOG amplification means to amplify the signals from the EOG electrode, the EOG amplification means connected to the analog/digital converter and the EOG electrode and EOG amplification means constituting an EOG channel; (i) quantification means in the computer system of (e) to quantify the EEG data by spectral analysis using FFT (Fast Fourier Transform) and to detect artifact by regressing out the EOG channel from every EEG channel by comparison of the EOG channel and each EEG channel; and to reject any of the intervals in which the voltage exceeds a multiple of the r m s voltage equal to 6×the standard deviation of means amplitude; (j) test score pair comparison means in the computer system to form at least 24 pairs of test scores, each pair comprising two test scores from duplicated tests, to compare one test score of each pair with the other test score of the same pair to arrange the test scores of each pair into respective odd and even matrices each matrix consisting of rows and columns of test scores with the test scores of each pair being at the corresponding location in each matrix; and to accept for further analysis only those pairs in which the two test scores of the pair are sufficiently alike within a predetermined definition; (k) normal comparison means in the computer system to compare accepted pairs of test scores with the normal group test scores of (g) and to identify, as being abnormal, those accepted pairs of test scores which are significantly deviant from the normal group test scores of (g); and (1) signal means to signal the finding by (k) of abnormal test scores of the patient.

Claim 17

A system as in claim 14 and including mean feature means in the computer system of (e) to analyze the EEG data separately in the delta, theta, alpha and beta bands of brain wave frequencies and separately in each of the bands for each of the features of absolute power, relative power coherence and symmetry for each of the EEG channels and for homologous pairs of EEG channels to provide a set of mean feature values.

Claim 18

A system as in claim 15 and including correction means in the computer system of (e) to correct the mean feature values for Gaussianity.

Claim 19

A system as in claim 15 and including means to store age regression equations and to correct the mean feature values according to the age of the patient using the stored age-regression equations.

Claim 20

A system as in claim 14 including software means to join the EEG data, meeting a predetermined definition of being artifact-free into a continuous artifact-free record and to slice the artifact-free record into at least 48 segments each of at least 1 second in duration.

Claim 21

A system as in claim 14 wherein the computer system of (e) includes means to perform a spectral analysis of the EEG data using FFT (Fast Fourier Transform).

Claim 22

A system as in claim 14 wherein the computer system of (e) includes means to analyze the EEG data signals by average response computation.

Claim 23

A system as in claim 14 and further comprising a display means connected to the computer system to display the analog brain waves amplified by the amplifiers.

Claim 24

A system as in claim 14 wherein the significantly deviant level of (h) is defined to be at the P<0.01 level.

Claim 25

An eletroencephalographic (EEG) and electrocardiographic (EKG) system comprising: (a) a plurality of EEG electrodes adapted to be removably secured to the scalp of the patient, including a fiducial electrode, each EEG electrode being a portion of a brain wave signal channel, and a plurality of EKG electrodes adapted to be removably secured to the skin of the patient to detect heart beats; (b) a preamplifier means connected to the EEG electrodes to amplify the analog microvolt level brain wave signals from the EEG electrodes in each of the channels; (c) a plurality of EKG amplifiers adapted at times to be removably connected to the plurality of EEG electrodes and adapted to be removably connected at other times to the EKG electrodes, the number of EKG amplifiers being less than two-thirds the number of EEG electrodes; (d) switching means to sample the larger number of EEG electrodes by the smaller number of EKG amplifiers; (e) an analog/digital converter means connected to the EKG amplifiers to produce EEG data consisting of amplified and digitized brain wave signals; (f) a micro-processor based computer system means connected to the analog/digital converter to analyze the EEG data; (g) a patient stimulator means connected to and controlled by the compute system means to provide a selected pattern of stimulation to the patient to evoke the patient's brain wave responses in a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; (h) a computer memory means connected to the computer system means to store the test scores of normal groups to a set of evoked potential tests corresponding to the tests given to the patient; (i) means in the computer system means to compare the test scores of each patient with normal group mean test scores stored in the computer memory means; and (j) display means to display the results of the test score comparisons and EKG heartbeat waveshapes.

Claim 26

An eletroencephalographic (EEG) and electrocardiographic (EKG) system comprising: (a) a plurality of EEG electrodes adapted to be removably secured to the scalp of the patient, including a fiducial electrode, each EEG electrode being a portion of a brain wave signal channel, and a plurality of EKG electrodes adapted to be removably secured to the skin of the patient to detect heart beats; (b) a preamplifier means connected to the EEG electrodes to amplify the analog microvolt level brain wave signals from the EEG electrodes in each of the channels; (c) a plurality of EKG amplifiers adapted at times to be removably connected to the plurality of EEG electrodes and adapted to be removably connected at other times to the EKG electrodes, the number of EKG amplifiers being less than two-thirds the number of EEG electrodes; (d) switching means to sample the larger number of EEG electrodes by the smaller number of EKG amplifiers; (e) an analog/digital converter means connected to the EKG amplifiers to produce EEG data consisting of amplified and digitized brain wave signals; (f) a micro-processor based computer system means connected to the analog/digital converter to analyze the EEG data; (g) a patient stimulator means connected to and controlled by the compute system means to provide a selected pattern of stimulation to the patient to evoke the patient's brain wave responses in a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; (h) a computer memory means connected to the computer system means to store the test scores of normal groups to a set of evoked potential tests corresponding to the tests given to the patient; (i) means in the computer system means to compare the test scores of each patient with normal group mean test scores stored in the computer memory means; and (j) display means to display the results of the test score comparisons and EKG heartbeat waveshapes.

Claim 27

A system as in claim 23 and further including a test score pair comparison means in the computer system means (e) to form at least 24 pairs of test scores, each pair comprising two test scores from duplicated tests, to compare one test score of each pair with the other test score of the same pair, and to accept for further analysis only those pairs in which the two test scores of the pair are sufficiently alike within a predetermined definition; wherein the accepted pairs of test scores are compared in (i) with the normal group test scores of (h) to identify, as being abnormal, those accepted pairs of test sources which are significantly deviant from the normal group test scores of (h).

Claim 28

A system as in claim 24 wherein the test score comparison means arranges the test scores of each pair into respective odd and even matrices, each matrix consisting of rows and columns of test scores, with the test scores of each pair being at corresponding locations in each matrix.

Claim 29

A system as in claim 23 including an EOG (electro-oculogram) electrode adapted to be removably positioned proximate an eye of the patient to detect blinking.

Claim 30

A system as in claim 26 and including means in the computer system of (e) to quantify the EEG data by spectral analysis using FFT (Fast Fourier Transform) and to detect artifact by regressing out the EOG channel from every EEG channel by comparison of the EOG channel and each EEG channel; and to reject any intervals in which the voltage exceeds a multiple of the r m s voltage equal to 6×the standard deviation of means amplitude.

Claim 31

A system as in claim 23 and including mean feature means in the computer system of (e) to analyze the EEG data separately in the delta, theta, alpha and beta bands of brain wave frequencies and separately in each of the bands for each of the features of absolute power, relative power coherence and symmetry for each of the EEG channels and for homologous pairs of EEG channels to provide a set of mean feature values.

Claim 32

A system as in claim 28 and including correction means in the computer system of (e) to correct the mean feature values for Gaussianity.

Claim 33

A system as in claim 28 and including means to store age regression equations and to correct the mean feature values according to the age of the patient using the stored age-regression equations.

Claim 34

A system as in claim 23 including software means such that the EEG data meeting a predetermined definition of being artifact-free is joined into a continuous artifact-free record and then sliced into at least 48 segments each of at least 1 second in duration.

Claim 35

A system as in claim 23 wherein the computer system of (e) includes means to perform a spectral analysis of the EEG data using FFT (Fast Fourier Transform).

Claim 36

A system as in claim 23 wherein the computer system of (e) includes means to analyze the EEG data by average response computation.

Claim 37

A system as in claim 23 and further comprising a display means to display the analog brain waves amplified by the amplifiers.

Claim 38

A system as in claim 23 wherein the significantly deviant level of (h) is defined to be at the P<0.01 level.

Claim 39

An electroencephalographic (EEG) method comprising the steps of: (a) removably attaching a plurality of EEG electrodes including a fiducial electrode to the scalp of the patient, each EEG electrode being a portion of a brain wave signal channel; (b) connecting the EEG electrodes to an amplifier means to amplify the analog microvolt level brain wave signals from the EEG electrodes in each brain wave signal channel, the amplifier means consisting of a plurality of fewer amplifiers than two-thirds the number of the EEG electrodes; (c) switching the amplifiers to the EEG electrodes to sample the larger number of electrodes by the smaller number of amplifiers; (d) producing EEG data using an analog/digital converter connected to the amplifiers, the EEG data consisting of amplified and digitized brain wave signals; (e) analyzing the EEG data in a micro-processor based computer system connected to the analog/digital converter; (f) stimulating the patient in a preselected pattern of stimulations using a patient stimulator means connected to and controlled by the computer system means, the selected pattern of stimulation to the patient evoking the patient's brain wave responses to provide a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; (g) storing the test scores of normal groups to a set of evoked potential tests corresponding to the evoked potential tests given to the patient in a computer memory means connected to the computer system means; (h) comparing pairs of test scores in the computer system from at least 24 pairs of different test scores, each pair comprising two test scores from duplicated tests by comparing one test score of each pair with the other test score of the same pair; and accepting for further analysis only those pairs in which the two test scores of the pair are sufficiently alike within a predetermined definition; (i) comparing accepted pairs of test scores with the normal group test scores of (g) and identifying, as being abnormal, those accepted pairs of test sources which are significantly deviant from the normal group test scores of (g); and (j) signaling the finding by (i) of abnormal test scores of the patient.

Claim 40

An electroencephalographic (EEG) method comprising the steps of: (a) removably attaching a plurality of EEG electrodes including a fiducial electrode to the scalp of the patient, each EEG electrode being a portion of a brain wave signal channel; (b) connecting the EEG electrodes to an amplifier means to amplify the analog microvolt level brain wave signals from the EEG electrodes in each brain wave signal channel, the amplifier means consisting of a plurality of fewer amplifiers than two-thirds the number of the EEG electrodes; (c) switching the amplifiers to the EEG electrodes to sample the larger number of electrodes by the smaller number of amplifiers; (d) producing EEG data using an analog/digital converter connected to the amplifiers, the EEG data consisting of amplified and digitized brain wave signals; (e) analyzing the EEG data in a micro-processor based computer system connected to the analog/digital converter; (f) stimulating the patient in a preselected pattern of stimulations using a patient stimulator means connected to and controlled by the computer system means, the selected pattern of stimulation to the patient evoking the patient's brain wave responses to provide a set of evoked potential tests, each test being the brain wave evoked responses at a selected frequency range and at a selected electrode to a selected simulation; (g) storing the test scores of normal groups to a set of evoked potential tests corresponding to the evoked potential tests given to the patient in a computer memory means connected to the computer system means; (h) comparing pairs of test scores in the computer system from at least 24 pairs of different test scores, each pair comprising two test scores from duplicated tests by comparing one test score of each pair with the other test score of the same pair; and accepting for further analysis only those pairs in which the two test scores of the pair are sufficiently alike within a predetermined definition; (i) comparing accepted pairs of test scores with the normal group test scores of (g) and identifying, as being abnormal, those accepted pairs of test sources which are significantly deviant from the normal group test scores of (g); and (j) signaling the finding by (i) of abnormal test scores of the patient.

Claim 41

A method as in claim 36 wherein the test score comparison means of (h) arranges the test scores of each pair into respective odd and even matrices, each matrix consisting of rows and columns of test scores with the test scores of each pair being at corresponding locations in each matrix.

Claim 42

A method as in claim 36 wherein in (h) there are at least 48 pairs of the test scores.

Claim 43

A method as in claim 36 and including the step of removably positioning an EOG electrode proximate an eye of the patient to detect blinking, the EOG electrode being part of an EOG channel.

Claim 44

A method as in claim 39 and quantifying the EEG data using means in the computer system of (e) to quantify the EEG data by spectral analysis using FFT (fast Fourier Transform) and detecting artifact by regressing out the EOG channel from every EEG channel by comparison of the EOG channel and each EEG channel and rejecting any intervals in which the voltage exceeds a multiple of the r m s voltage equal to 6×the standard deviation of means amplitude.

Claim 45

A method as in claim 36 and including using mean feature means in the computer system of (e) to analyze the EEG data separately in the delta, theta alpha and beta bands of brain wave frequencies and separately in each of the bands for each of the features of absolute power, relative power coherence and symmetry for each of the EEG channels and for homologous pairs of EEG channels to provide a set of mean feature values.

Claim 46

A method as in claim 41 and including using correction means in the computer system of (e) to correct the mean feature values for Gaussianity.

Claim 47

A method as in claim 41 and including storing age regression equations in computer system memory and correcting the mean feature values according to the age of the patient.

Claim 48

A method as in claim 36 including software means to join EEG data, meeting a predetermined definition of being artifact-free, into a continuous artifact-free record and to slice the joined artifact-free record into at least 48 segments each of at least 1 second in duration.

Claim 49

A method as in claim 36 and including the step of performing a spectral analysis of the EEG data using FFT (Fast Fourier Transform) using the computer system.

Claim 50

A method as in claim 36 and including the step of analyzing the EEG data signals by average response computation using the computer system.

Claim 51

A method as in claim 36 and including displaying the analog brain waves amplified by the amplifiers in display means connected to the computer system.

Claim 52

A method as in claim 36 wherein the significantly deviant level of (h) is defined to be at the P<0.01 level.