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US5270047A
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US
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Local delivery of dipyridamole for the treatment of proliferative diseases
Assignee: Eli Lilly and Co
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Filing: 1991-11-21
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Granted: 1993-12-14
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Expires: 2011-11-21
Abstract
Abstract A method of inhibiting cell proliferation in mammals which comprises the local delivery of an inhibitory amount of dipyridamole. Inhibiting cell proliferation is useful for the treatment of proliferaive diseases such as vascular restonesis, scleroderma, psoriasis, and rheumatoid arthritis. This method includes the local delivery of dipyridamole to the proliferative site by various techniques including local delivery catheters, site specific carriers, implants, direct injection, or direct application.
Inventors
- 👤 Raymond F. Kauffman
- 👤 Jai P. Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61P; A61P29/00; A61P35/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
24 words
A method of inhibiting cell proliferation in mammals which comprises the local delivery of a therapeutic amount of dipyridamole sufficient to inhibit cell proliferation.
Claim 2
Independent Claim
24 words
A method of inhibiting cell proliferation in mammals which comprises the local delivery of a therapeutic amount of dipyridamole sufficient to inhibit cell proliferation.
Claim 3
Dependent Claim
16 words
The method of use of claim 1 wherein the cells inhibited are vascular smooth muscle cells.
Claim 4
Dependent Claim
14 words
The method of use of claim 1 wherein the cells inhibited are fibroblast cells.
Claim 5
Dependent Claim
14 words
The method of use of claim 1 wherein the cells inhibited are mesenchymal cells.
Claim 6
Dependent Claim
17 words
The method of use of claim 1 where the local delivery is by means of direct application.
Claim 7
Dependent Claim
17 words
The method of use of claim 2 where the local delivery is by means of direct application.
Claim 8
Dependent Claim
17 words
The method of use of claim 3 where the local delivery is by means of direct application.
Claim 9
Dependent Claim
17 words
The method of use of claim 4 where the local delivery is by means of direct application.
Claim 10
Independent Claim
47 words
A method of inhibiting cell proliferation in mammals which comprises the local delivery of a therapeutic amount of dipyridamole sufficient to inhibit cell proliferation wherein said cellular proliferation is induced by growth factors comprising platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and/or fibroblast growth factor (FGF).
Claim 11
Independent Claim
47 words
A method of inhibiting cell proliferation in mammals which comprises the local delivery of a therapeutic amount of dipyridamole sufficient to inhibit cell proliferation wherein said cellular proliferation is induced by growth factors comprising platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and/or fibroblast growth factor (FGF).
References Cited (Backward Citations)
US4824436A
Cited
EP0383429A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-12-13 | 1997-06-14 | 1997-12-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-12-13 | 2001-06-14 | 2001-12-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-12-13 | 2005-06-14 | 2005-12-14 | $7700.00 | Window Closed / Lapsed |