US5266327A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enhanced suturing and means therefor
Assignee: Newcastle Innovation Ltd
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Filing: 1991-02-08
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Granted: 1993-11-30
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Expires: 2011-02-08
Abstract
Abstract The present invention relates to a surgical securing means having releaseably associated therewith a peptide, said peptide comprising the amino acid sequence: [aa].sub.n -[RG-(x).sub.n.sbsb.1 ].sub.n.sbsb.2 -[aa].sub.n.sbsb.3 wherein R is arginine; G is glycine; x is aspartate or glutamate; aa is any amino acid; and n is 0-100; n 1 is 0 or 1 n 2 is 1-100 n 3 is 0-100 and wherein said peptide is released in an amount effective to induce fibroblast-mediated collagen lattice contraction.
Inventors
- 👤 Michael V. Agrez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:59
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L; A61L17/00; A61L17/005; A61L17/06; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/14; A61L31/148; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61L2300/00; A61L2300/20; A61L2300/25; A61L2300/40; A61L2300/412
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
43 words
A surgical securing means comprising a peptide selected from the group consisting of Arg-Gly-Glu-Ser and Arg-Gly-Asp releasably coated and/or impregnated onto a surgical securing device wherein said peptide is released from said device in an amount effective to induce fibroblast-mediated collagen lattice contraction.
Claim 2
Dependent Claim
43 words
A surgical securing means comprising a peptide selected from the group consisting of Arg-Gly-Glu-Ser and Arg-Gly-Asp releasably coated and/or impregnated onto a surgical securing device wherein said peptide is released from said device in an amount effective to induce fibroblast-mediated collagen lattice contraction.
Claim 3
Dependent Claim
17 words
A surgical securing means in accordance with claim 1 wherein said surgical securing device is a suture.
Claim 4
Dependent Claim
18 words
A surgical securing means in accordance with claim 1 wherein said surgical securing device is a surgical staple.
Claim 5
Dependent Claim
18 words
A surgical securing means in accordance with claim 1 wherein said surgical securing device is an adsorbable screw.
Claim 6
Dependent Claim
19 words
A surgical securing means in accordance with claim 1, 2 or 3 wherein said surgical securing device is biodegradable.
Claim 7
Dependent Claim
40 words
A surgical securing means in accordance with claim 1 wherein said effective amount of said peptide released from said device is from about 10 to about 400 micrograms per ml. of fluid in the local environment around the securing device.
Claim 8
Dependent Claim
14 words
A surgical securing means in accordance with claim 1 wherein said peptide is Arg-Gly-Glu-Ser.
Claim 9
Dependent Claim
14 words
A surgical securing means in accordance with claim 1 wherein said peptide is Arg-Gly-Asp.
Claim 10
Independent Claim
45 words
A method of intestinal anastomosis comprising intestinal anastomosing with a surgical securing device releasably coated and/or impregnated with a peptide selected from the group consisting of Arg-Gly-Glu-Ser and Arg-Gly-Asp and wherein said peptide is released in an amount effective to induce faberblast-mediated collagen lattice contraction.
Claim 11
Independent Claim
45 words
A method of intestinal anastomosis comprising intestinal anastomosing with a surgical securing device releasably coated and/or impregnated with a peptide selected from the group consisting of Arg-Gly-Glu-Ser and Arg-Gly-Asp and wherein said peptide is released in an amount effective to induce faberblast-mediated collagen lattice contraction.
Claim 12
Dependent Claim
15 words
A method in accordance with claim 9 wherein said surgical securing device is a suture.
Claim 13
Dependent Claim
16 words
A method in accordance with claim 9 wherein said surgical securing device is a surgical staple.
Claim 14
Dependent Claim
16 words
A method in accordance with claim 9 wherein said surgical securing device is an adsorbable screw.
Claim 15
Dependent Claim
15 words
A method in claim 9, 10 or 11 wherein said surgical securing device is biodegradable.
Claim 16
Dependent Claim
38 words
A method in accordance with claim 9 wherein said effective amount of said peptide released from said device is from about 10 to about 400 micrograms per ml. of fluid in the local environment around the securing device.
Claim 17
Dependent Claim
12 words
A method in accordance with claim 9 wherein said peptide is Arg-Gly-Glu-Ser.
Claim 18
Dependent Claim
12 words
A method in accordance with claim 9 wherein said peptide is Arg-Gly-Asp.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-29 | 1997-05-31 | 1997-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-29 | 2001-05-31 | 2001-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-29 | 2005-05-31 | 2005-11-30 | $7700.00 | Window Closed / Lapsed |