Patent US5246437A successfully refreshed from Google Patents.
US5246437A
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Cell treatment apparatus and method
Assignee: Individual
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Filing: 1992-04-10
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Granted: 1993-09-21
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Expires: 2012-04-10
Abstract
Abstract A catheter arrangement and associated method provides for the application of a cell treatment agent, such as genetic material or drugs to be inserted within the cells of a patient in vivo. The catheter arrangement uses an optical fiber having a prism at its tip. Laser energy from the optical fiber is directed by the prism through a window portion on a side of the catheter. The window portion has a plurality of holes so as to divide the laser energy into a plurality of microbeams. The microbeams porate cell walls of the patient's cells. A treatment agent channel in the catheter allows the treatment agent to be provided directly to the same holes through which the microbeams pass such that the treatment agent is very efficiently applied to the porations in the cell walls.
Inventors
- 👤 George S. Abela
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:42
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B17/00; A61B17/22; A61B2017/22038; A61B2017/22082; A61B2018/2255; A61B2018/2272
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
122 words
An apparatus for patient treatment comprising: a laser catheter including an optical fiber, a body having a wall with a grating portion having grating means disposed therein to pass laser energy from said optical fiber in the form of a plurality of at least three distinct beams, and a treatment agent channel inside said body, each of said beams passing out of said grating portion with a width of less than 200 microns for poration of a patient's cells in vivo, said treatment agent channel in fluid communication with said grating means and operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams.
Claim 2
Independent Claim
122 words
An apparatus for patient treatment comprising: a laser catheter including an optical fiber, a body having a wall with a grating portion having grating means disposed therein to pass laser energy from said optical fiber in the form of a plurality of at least three distinct beams, and a treatment agent channel inside said body, each of said beams passing out of said grating portion with a width of less than 200 microns for poration of a patient's cells in vivo, said treatment agent channel in fluid communication with said grating means and operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams.
Claim 3
Dependent Claim
26 words
The apparatus of claim 1 wherein said plurality of distinct beams include at least three beams passing through said grating portion in the same general direction.
Claim 4
Dependent Claim
30 words
The apparatus of claim 2 wherein said grating portion has a plurality of openings, each opening corresponding on a one-to-one basis with one beam of said plurality of distinct beams.
Claim 5
Dependent Claim
18 words
The apparatus of claim 3 wherein each of said openings has a width of less than 100 microns.
Claim 6
Dependent Claim
65 words
The apparatus of claim 1 wherein said grating portion has a plurality of openings through which laser energy may pass and wherein said treatment agent channel is connected to said plurality of openings for supplying treatment agent by way of said plurality of openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 7
Dependent Claim
39 words
The apparatus of claim 5 further comprising a flushing solution catheter connected to said laser catheter and having a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 8
Dependent Claim
27 words
The apparatus of claim 6 wherein said flushing solution catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for controlling said balloon.
Claim 9
Dependent Claim
82 words
The apparatus of claim 1 wherein said grating portion is on a side of said body, wherein said grating portion has a plurality of openings, each opening corresponding on a one-to-one basis with one beam of said plurality of distinct beams, and wherein said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 10
Independent Claim
142 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window portion disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window portion passing laser energy for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams, said treatment catheter further including a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient, and wherein said window portion includes grating means which pass laser energy in a plurality of distinct beams, each of which has a width of less than 100 microns.
Claim 11
Independent Claim
142 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window portion disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window portion passing laser energy for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams, said treatment catheter further including a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient, and wherein said window portion includes grating means which pass laser energy in a plurality of distinct beams, each of which has a width of less than 100 microns.
Claim 12
Dependent Claim
37 words
The apparatus of claim 9 wherein said grating means has a plurality of openings, each opening corresponding on a one-to-one basis with one beam of a plurality of distinct beams in which said laser energy is disposed.
Claim 13
Dependent Claim
45 words
The apparatus of claim 10 wherein said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 14
Dependent Claim
59 words
The apparatus of claim 11 wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon, said window portion is on a side of said body, and wherein said window portion passes laser energy in a plurality of distinct beams, each having a width of less than 100 microns.
Claim 15
Independent Claim
217 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window portion disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window portion passing laser energy in a form including at least one beam passing through an opening of less than 200 microns in said window portion, said treatment agent channel disposed to supply treatment agent by way of said opening to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said laser energy and wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon and said window portion is on a side of said body and wherein said window portion has a grating means with a plurality of openings, each opening corresponding on a one-to-one basis with one beam of a plurality of distinct beams in which said laser energy is disposed, and each opening connected to said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 16
Independent Claim
217 words
An apparatus for patient treatment comprising: a treatment catheter including an optical fiber, a body having a wall with a window portion disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window portion passing laser energy in a form including at least one beam passing through an opening of less than 200 microns in said window portion, said treatment agent channel disposed to supply treatment agent by way of said opening to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said laser energy and wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon and said window portion is on a side of said body and wherein said window portion has a grating means with a plurality of openings, each opening corresponding on a one-to-one basis with one beam of a plurality of distinct beams in which said laser energy is disposed, and each opening connected to said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 17
Dependent Claim
57 words
The apparatus of claim 13 wherein said treatment catheter includes a laser catheter having said optical fiber, said body and said treatment agent channel and a flushing solution catheter connected to said laser catheter and having a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 18
Dependent Claim
25 words
The apparatus of claim 13 wherein each beam has a width of less than 100 microns and each opening is less than 100 microns across.
Claim 19
Independent Claim
123 words
An apparatus for patient treatment comprising: a laser catheter including an optical fiber, a body having a wall with a window portion disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window portion having grating means for passing laser energy in the form of a plurality of distinct beams, there being at least three distinct beams, each of the three beams passes out of said window portion in the same general direction for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams.
Claim 20
Independent Claim
123 words
An apparatus for patient treatment comprising: a laser catheter including an optical fiber, a body having a wall with a window portion disposed therein to pass laser energy from said optical fiber, and a treatment agent channel inside said body, said window portion having grating means for passing laser energy in the form of a plurality of distinct beams, there being at least three distinct beams, each of the three beams passes out of said window portion in the same general direction for poration of a patient's cells in vivo, said treatment agent channel operable to supply treatment agent to a location for entry into a patient's cells in vivo after the patient's cells have been porated by said plurality of distinct beams.
Claim 21
Dependent Claim
37 words
The apparatus of claim 16 wherein said treatment catheter includes a balloon mounted thereon and a balloon channel connected to said balloon for inflating said balloon and said window portion is on a side of said body.
Claim 22
Dependent Claim
78 words
The apparatus of claim 16 wherein said window portion has a plurality of openings, each opening corresponding on a one-to-one basis with one beam of a plurality of distinct beams in which said laser energy is disposed and wherein said treatment agent channel is connected to said openings for supplying treatment agent by way of said openings for pressurized flow towards a patient's cells for entry therein after the patient's cells have been porated by said laser energy.
Claim 23
Dependent Claim
39 words
The apparatus of claim 18 further comprising a flushing solution catheter connected to said laser catheter and having a flushing solution channel terminating in a flushing solution exit for applying flushing solution to a treatment site in a patient.
Claim 24
Independent Claim
106 words
A method of treating cells of a patient in vivo comprising the steps of: applying laser energy to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and wherein the step of applying laser energy uses application of laser energy in the form of a plurality of distinct beams including at least first and second beams, said first beam applied to a first one of said cells when said second beam is applied to a second one of said cells.
Claim 25
Independent Claim
106 words
A method of treating cells of a patient in vivo comprising the steps of: applying laser energy to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and wherein the step of applying laser energy uses application of laser energy in the form of a plurality of distinct beams including at least first and second beams, said first beam applied to a first one of said cells when said second beam is applied to a second one of said cells.
Claim 26
Dependent Claim
26 words
The method of claim 20 wherein the treatment agent includes a DNA plasmid and the applying of the treatment agent causes the cells to be transfected.
Claim 27
Independent Claim
128 words
A method of treating cells of a patient in vivo comprising the steps of: applying laser energy to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and wherein the treatment agent includes a DNA plasmid and the applying of the treatment agent causes the cells to be transfected and wherein the step of applying laser energy uses application of laser energy in the form of a plurality of distinct beams including at least first and second beams, said first beam applied to a first one of said cells when said second beam is applied to a second one of said cells.
Claim 28
Independent Claim
128 words
A method of treating cells of a patient in vivo comprising the steps of: applying laser energy to the cells of the patient in vivo to cause porations in the cells; and applying a treatment agent to the cells having porations therein such that the treatment agent enters the cells through the porations; and wherein the treatment agent includes a DNA plasmid and the applying of the treatment agent causes the cells to be transfected and wherein the step of applying laser energy uses application of laser energy in the form of a plurality of distinct beams including at least first and second beams, said first beam applied to a first one of said cells when said second beam is applied to a second one of said cells.
Claim 29
Dependent Claim
39 words
The method of claim 22 further comprising the step of inserting a laser catheter into the patient and wherein said beams are applied to the cells after leaving said laser catheter with a width of less than 200 microns.
Claim 30
Dependent Claim
41 words
The method of claim 23 wherein said beams leave said laser catheter with a width of less than 100 microns and wherein there are at least 12 of said beams which exit through openings on a side of said laser catheter.
Claim 31
Dependent Claim
35 words
The method of claim 23 wherein said laser beams exit from openings on a side of said catheter and said treatment agent is forced out said openings to follow multiple paths corresponding to said beams.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-20 | 1997-03-22 | 1997-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-20 | 2001-03-22 | 2001-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-20 | 2005-03-22 | 2005-09-21 | $7700.00 | Window Closed / Lapsed |