Abstract Novel modified polymeric materials are provided. The polymeric materials according to the invention are prepared by grafting a fluorine-containing compound onto a polyurethane polymeric substrate. The polymeric materials show superior blood compatibility in the in vitro and ex vivo tests, attributing to hydrophobic property, inertness and water-repelling property intrinsic to the grafted fluorine containing compounds. The polymeric materials according to the invention are useful as the materials for the artificial, circulatory, internal organ systems to be contacted with blood, such as artificial hearts, artificial blood vessels, artificial heart valves, artificial blood oxygenators, and artificial kidneys, or for the medical devices/instruments to be inserted into the blood vessels, such as vein catheters, artery catheters and intra-aortic balloon pumps.
A process for the preparation of modified polymeric mateirals which comprises reacting a polymeric substrate selected from the group consisting of polyurethane and copolymers thereof directly with a derivative of a fluorine-containing compound selected from the group consisting of saturated C 1 -C.sub. aliphatic perfluorocarbons having a halogen substituent at one terminal in the presence of a strong base.
Claim 2
Dependent Claim
59 words
A process for the preparation of modified polymeric mateirals which comprises reacting a polymeric substrate selected from the group consisting of polyurethane and copolymers thereof directly with a derivative of a fluorine-containing compound selected from the group consisting of saturated C 1 -C.sub. aliphatic perfluorocarbons having a halogen substituent at one terminal in the presence of a strong base.
Claim 3
Dependent Claim
29 words
The process of claim 1, wherein the strong base is selected from the group consisting of sodium and potassium hydride, sodium and potassium ethoxide, and sodium and potassium butylate.
Claim 4
Dependent Claim
15 words
A modified polymeric material with improved blood compatibility produced by the process of claim 1.
Claim 5
Dependent Claim
33 words
The modified polymeric material of claim 3, wherein the material is useful as the materials for artificial hearts, artificial blood vessels, artificial heart valves, artificial blood oxygenators, artificial kidneys or blood vessel catheters.