Patent US2392324A successfully refreshed from Google Patents.
Patent US5222953A successfully refreshed from Google Patents.
US5222953A
Expired / Lapsed
US
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Apparatus for interstitial laser therapy having an improved temperature sensor for tissue being treated
Assignee: Novian Health Inc
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Filing: 1991-10-02
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Granted: 1993-06-29
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Expires: 2011-10-02
Abstract
Abstract Improved apparatus for carrying out minimally invasive interstitial laser hyperthermia to induce coagulation necrosis in tissue masses located deeply within the body of a subject. Among examples are malignant tumors in the liver or breast. Low power laser radiation is introduced through an optical fiber extending through a cannula or probe guided into place by medical imaging techniques and inserted directly into the target tissue mass. A thermocouple is secured to the outside of the cannula to sense the temperature of the target tissue irradiated by the laser energy. The thermocouple is located slightly behind the distal end of the cannula and the entire probe assembly is gold plated enabling it to respond primarily to heat transmitted by conduction from the tissue and not by radiation from the laser. In one operating mode described, after the probe is inserted into the tumor, the probe is withdrawn while laser energy is administered at a rate sufficient to maintain the temperature at the thermocouple within a predetermined therapeutic range. In one motorized embodiment, a motor withdraws the cannula at a predetermined speed while the laser is firing, to maintain an effectively high uniform tissue temperature. In another automatic embodiment, the motor speed is controlled in response to the tissue temperature sensed by the thermocouple on the outside of the cannula. This leaves a cylindrical core of necrotic tumor tissue in the wake of the probe as it is drawn through the target tissue.
Inventors
- 👤 Kambiz Dowlatshahi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:29
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/06; A61N5/0601; A61B; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00084; A61B2017/00092; A61B17/22; A61B2017/22072; A61B2017/22074; A61B2017/22077; A61B18/00; A61B18/18; A61B18/20; A61B2018/2005
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
140 words
Apparatus for interstitial laser therapy comprising in combination: a thin cannula for insertion in a tissue mass, said cannula having a lumen extending axially between proximal and distal end portions and a distally facing central axial opening at the distal end communicating with the lumen, said lumen being adapted to receive an optical fiber for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted; a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and said temperature sensing means is proximally spaced from the outside distal end of the cannula to be out of a direct line of view with said central axial opening.
Claim 2
Dependent Claim
140 words
Apparatus for interstitial laser therapy comprising in combination: a thin cannula for insertion in a tissue mass, said cannula having a lumen extending axially between proximal and distal end portions and a distally facing central axial opening at the distal end communicating with the lumen, said lumen being adapted to receive an optical fiber for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted; a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and said temperature sensing means is proximally spaced from the outside distal end of the cannula to be out of a direct line of view with said central axial opening.
Claim 3
Dependent Claim
67 words
Apparatus for interstitial laser therapy according to claim 1 in which an optical fiber is disposed in said lumen and the distal end of the optical fiber is substantially flush with the distal end of the cannula and effective when laser energy is applied to the proximal end of the optical fiber to emit laser energy distally and axially from the distal end of the optical fiber.
Claim 4
Dependent Claim
153 words
Apparatus for interstitial laser therapy comprising in combination: a thin cannula for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions and being adapted to receive an optical fiber for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted; a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and said temperature sensing means and at least the immediately adjacent surface of the cannula having a highly reflective surface having reflectivity in the order of magnitude of gold plating; whereby the temperature sensing means is sensitive primarily to heat received by conduction and not by reflection from tissue in which the distal end portion of the cannula is inserted.
Claim 5
Dependent Claim
153 words
Apparatus for interstitial laser therapy comprising in combination: a thin cannula for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions and being adapted to receive an optical fiber for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted; a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and said temperature sensing means and at least the immediately adjacent surface of the cannula having a highly reflective surface having reflectivity in the order of magnitude of gold plating; whereby the temperature sensing means is sensitive primarily to heat received by conduction and not by reflection from tissue in which the distal end portion of the cannula is inserted.
Claim 6
Dependent Claim
156 words
In apparatus for interstitial laser therapy including a thin cannula having a lumen for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions and an optical fiber in said lumen for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted, the improvement comprising: a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and said temperature sensing means and at least the immediately adjacent surface of the cannula having a highly reflective surface having reflectivity in the order of magnitude of gold plating; whereby the temperature sensing means is sensitive primarily to heat received by conduction and not by reflection from tissue in which the distal end of the cannula is inserted.
Claim 7
Dependent Claim
156 words
In apparatus for interstitial laser therapy including a thin cannula having a lumen for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions and an optical fiber in said lumen for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted, the improvement comprising: a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and said temperature sensing means and at least the immediately adjacent surface of the cannula having a highly reflective surface having reflectivity in the order of magnitude of gold plating; whereby the temperature sensing means is sensitive primarily to heat received by conduction and not by reflection from tissue in which the distal end of the cannula is inserted.
Claim 8
Dependent Claim
124 words
In apparatus for interstitial laser therapy including a thin cannula having a lumen for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions and an optical fiber in said lumen for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted, the improvement comprising: a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and motor-driven means connected to the cannula for withdrawing the cannula at predetermined speed from tissue in which the distal end portion of the cannula is inserted.
Claim 9
Dependent Claim
124 words
In apparatus for interstitial laser therapy including a thin cannula having a lumen for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions and an optical fiber in said lumen for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted, the improvement comprising: a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith to sense temperature of a tissue mass in which the distal end portion of the cannula is inserted; and motor-driven means connected to the cannula for withdrawing the cannula at predetermined speed from tissue in which the distal end portion of the cannula is inserted.
Claim 10
Dependent Claim
64 words
In apparatus for interstitial laser therapy, the improvement of claim 5 including temperature indicating means connected to said temperature sensing means to read a temperature sensed thereby, and automatic means for controlling the motor-driven means in response to the temperature indicating means to regulate speed of withdrawal of the cannula for maintaining temperature at the temperature sensing element within a predetermined therapeutic temperature range.
Claim 11
Dependent Claim
82 words
In apparatus for interstitial laser therapy, the improvement of claim 5 including temperature indicating means connected to said temperature sensing means to read a temperature sensed thereby laser generating means; means for transmitting laser energy from said laser generating means into said optical fiber; and automatic means for regulating the laser energy transmitted to the optical fiber in response to the temperature indicating means to thereby maintain the temperature of tissue sensed by said sensing means within a predetermined therapeutic temperature range.
Claim 12
Dependent Claim
176 words
Apparatus for interstitial laser therapy comprising in combination: a thin cannula for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions, said cannula having a distal end opening at the distal end of the lumen which is adapted to receive an optical fiber for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted; a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith, said temperature sensing means facing distally toward tissue beyond said distal end portion to sense temperature of such tissue heated by a laser beam transmitted through said distal end opening; and said temperature sensing means is spaced sufficiently from the outside distal end of the cannula that it is shaded from direct view of said opening and therefore is essentially non-responsive to laser energy emitted through said distal end opening; whereby said temperature sensing means is primarily responsive to temperature of tissue beyond said distal end portion.
Claim 13
Dependent Claim
176 words
Apparatus for interstitial laser therapy comprising in combination: a thin cannula for insertion in a tissue mass, said cannula having a lumen extending between proximal and distal end portions, said cannula having a distal end opening at the distal end of the lumen which is adapted to receive an optical fiber for transmitting laser energy into a tissue mass in which the distal end portion of the cannula is inserted; a temperature sensing means secured to the outside of the distal end portion of the cannula and movable therewith, said temperature sensing means facing distally toward tissue beyond said distal end portion to sense temperature of such tissue heated by a laser beam transmitted through said distal end opening; and said temperature sensing means is spaced sufficiently from the outside distal end of the cannula that it is shaded from direct view of said opening and therefore is essentially non-responsive to laser energy emitted through said distal end opening; whereby said temperature sensing means is primarily responsive to temperature of tissue beyond said distal end portion.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |