US5197466A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for volumetric interstitial conductive hyperthermia
Assignee: Cook Research Inc
•
Filing: 1992-01-07
•
Granted: 1993-03-30
•
Expires: 2012-01-07
Abstract
Abstract A system and method for producing volumetric conductive hyperthermia for the treatment of a cancerous tumor in a patient. The location and volume of the tumor are determined with the aid of a CT scanning system, and an array of probes each containing a heat-emitting element is formed by interstitial implantation in the tumor in a predetermined pattern for volumetric heating using a template for guiding the probes into parallel alignment in the tumor. The template is affixed with respect to the patient's body and with respect to the imaging plane of the CT scanning system. After implantation, the probes are connected to a manifold which is in turn connected to an external control system capable of independently controlling the probes while monitoring various analog and digital values representative of system performance.
Inventors
- 👤 J. Alexander Marchosky
- 👤 Christopher J. Moran
- 👤 Neal E. Fearnot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:29
CPC Classifications
A; A61; A61F; A61F7/00; A61F7/12; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1007; H; H02; H02J; H02J50/00; H02J50/10; A61B; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00084; A61F2007/0093; A61F2007/126; A61N2005/1011; A61N2005/1012; A61N5/1027; H02J2105/00; H02J2105/40; H02J2105/46; H02J7/00; H02J7/80; H02J7/82
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
106 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: an implantable, heat-emitting source responsive to power applied thereto for producing thermally conductive heat in a predetermined thermally conducted temperature distribution in said tissue mass when implanted in said tissue mass; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the power applied to said heat-emitting source for controlling the power applied to said heat-emitting source.
Claim 2
Independent Claim
106 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: an implantable, heat-emitting source responsive to power applied thereto for producing thermally conductive heat in a predetermined thermally conducted temperature distribution in said tissue mass when implanted in said tissue mass; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the power applied to said heat-emitting source for controlling the power applied to said heat-emitting source.
Claim 3
Independent Claim
95 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: implantable, heat-emitting means responsive to power applied thereto for producing thermally conductive heat in a predetermined thermally conducted temperature distribution in said tissue mass when implanted in said tissue mass in a predetermined pattern; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the power applied to said heat-emitting means for controlling the power applied to said heat-emitting means.
Claim 4
Independent Claim
95 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: implantable, heat-emitting means responsive to power applied thereto for producing thermally conductive heat in a predetermined thermally conducted temperature distribution in said tissue mass when implanted in said tissue mass in a predetermined pattern; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the power applied to said heat-emitting means for controlling the power applied to said heat-emitting means.
Claim 5
Dependent Claim
21 words
The system of claim 2 further comprising means for implanting said heat-emitting means in said tissue mass in said predetermined pattern.
Claim 6
Dependent Claim
19 words
The system of claim 2 wherein said heat-emitting means includes a plurality of probes each including a heater element.
Claim 7
Dependent Claim
25 words
The system of claim 4 wherein each of said plurality of probes further includes a tapered tip for implanting the probe in said tissue mass.
Claim 8
Dependent Claim
26 words
The system of claim 4 wherein each of said probes includes a temperature sensor of said sensor means for measuring an internal temperature of the probe.
Claim 9
Dependent Claim
29 words
The system of claim 6 wherein said control means is responsive to the internal temperature of each of said probes for controlling the power applied to said heater elements.
Claim 10
Dependent Claim
67 words
The system of claim 7 wherein each of said probes includes an outer surface and wherein said control means is responsive to the internal temperature of each of said probes for controlling the power applied to each of said heater elements to produce at least a predetermined temperature along the outer surface of the probe contributing to said predetermined thermally conducted temperature distribution in said tissue mass.
Claim 11
Dependent Claim
53 words
The system of claim 8 wherein each of said heater elements includes a resistive heating wire wound in a cylindrical tubular form, the power applied to each of the resistive heating wires being controlled by said control means to produce said at least a predetermined temperature along the outer surface of the probe.
Claim 12
Independent Claim
143 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of implantable probes each including a heater element, each of said heater elements being responsive to power applied thereto for producing thermally conductive heat in an individual, predetermined, thermally conducted temperature distribution in said tissue mass; said plurality of implantable probes also including a plurality of temperature sensors each for measuring temperature thereabout; and control means responsive to the temperature measured about each of said temperature sensors and the power applied to each of said heater elements when said plurality of probes are implanted in said tissue mass in a determinable pattern for controlling the power applied to each of said heater elements to produce a combinational, predetermined, thermally conducted temperature distribution in said tissue mass resulting from the individual temperature distributions.
Claim 13
Independent Claim
143 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of implantable probes each including a heater element, each of said heater elements being responsive to power applied thereto for producing thermally conductive heat in an individual, predetermined, thermally conducted temperature distribution in said tissue mass; said plurality of implantable probes also including a plurality of temperature sensors each for measuring temperature thereabout; and control means responsive to the temperature measured about each of said temperature sensors and the power applied to each of said heater elements when said plurality of probes are implanted in said tissue mass in a determinable pattern for controlling the power applied to each of said heater elements to produce a combinational, predetermined, thermally conducted temperature distribution in said tissue mass resulting from the individual temperature distributions.
Claim 14
Dependent Claim
17 words
The system of claim 9 further comprising template means for guiding said probes into said tissue mass.
Claim 15
Dependent Claim
52 words
The system of claim 9 wherein each of said heater elements includes a resistive heating wire wound in a cylindrical tubular form, the power applied to each of the resistive heating wires being controlled by said control means to produce at least a predetermined temperature along an outer surface of the probe.
Claim 16
Independent Claim
101 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of implantable probes each having an outer surface and including a heater element therein for producing thermally conductive heat; each of said probes also including a temperature sensor for determining an outer surface temperature of the probe; and control means responsive to the outer surface temperature determined by each of said sensors and a thermal conduction property of said tissue mass for controlling the power applied to said heater elements to produce a predetermined minimum temperature throughout said tissue mass.
Claim 17
Independent Claim
101 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of implantable probes each having an outer surface and including a heater element therein for producing thermally conductive heat; each of said probes also including a temperature sensor for determining an outer surface temperature of the probe; and control means responsive to the outer surface temperature determined by each of said sensors and a thermal conduction property of said tissue mass for controlling the power applied to said heater elements to produce a predetermined minimum temperature throughout said tissue mass.
Claim 18
Dependent Claim
27 words
The system of claim 13 wherein said control means is responsive to thermal conductivity of said tissue mass for controlling the power applied to said heater elements.
Claim 19
Dependent Claim
26 words
The system of claim 13 wherein said control means is responsive to perfusion of said tissue mass for controlling the power applied to said heater elements.
Claim 20
Dependent Claim
31 words
The system of claim 13 wherein said control means is responsive to a minimum tissue carry through temperature of said tissue mass for controlling the power applied to said heater elements.
Claim 21
Dependent Claim
29 words
The system of claim 13 wherein said control means is responsive to thermal conductivity and perfusion of said tissue mass for controlling the power applied to said heater elements.
Claim 22
Dependent Claim
44 words
The system of claim 13 wherein each of said heater elements includes a cylindrical shape, the power applied to each of the heater elements being controlled by said control means to produce at least a predetermined temperature along the outer surface of the probe.
Claim 23
Independent Claim
111 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: heat-emitting probe means shaped for interstitial implantation in said tissue mass and responsive to power applied thereto for radiating thermally conducted heat therefrom at a predetermined surface temperature; temperature sensor means for determining surface temperature of said probe means when implanted in said tissue mass; and control means responsive to the surface temperature determined by said temperature sensor means for controlling the power applied to said heat-emitting probe means when interstitially implanted in said tissue mass in a predetermined pattern for producing a predetermined thermally conducted temperature distribution in said tissue mass.
Claim 24
Independent Claim
111 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: heat-emitting probe means shaped for interstitial implantation in said tissue mass and responsive to power applied thereto for radiating thermally conducted heat therefrom at a predetermined surface temperature; temperature sensor means for determining surface temperature of said probe means when implanted in said tissue mass; and control means responsive to the surface temperature determined by said temperature sensor means for controlling the power applied to said heat-emitting probe means when interstitially implanted in said tissue mass in a predetermined pattern for producing a predetermined thermally conducted temperature distribution in said tissue mass.
Claim 25
Dependent Claim
18 words
The system of claim 19 further comprising template means for guiding said probe means into said tissue mass.
Claim 26
Dependent Claim
54 words
The system of claim 19 wherein each of said heat-emitting probe means includes a resistive heating wire wound in a cylindrical tubular form, the power applied to each of the resistive heating wires being controlled by said control means to produce at least a predetermined temperature along an outer surface of the probe means.
Claim 27
Independent Claim
106 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass having a temperature distribution in a patient, comprising: interstitially implantable, heat-emitting probe means responsive to power applied thereto for producing thermally conductive heat to change said temperature distribution of said tissue mass; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the power applied to said probe means for controlling the power applied to said interstitially implantable, heat-emitting probe means for producing thermally conductive heat to change said temperature distribution of said tissue mass.
Claim 28
Independent Claim
106 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass having a temperature distribution in a patient, comprising: interstitially implantable, heat-emitting probe means responsive to power applied thereto for producing thermally conductive heat to change said temperature distribution of said tissue mass; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the power applied to said probe means for controlling the power applied to said interstitially implantable, heat-emitting probe means for producing thermally conductive heat to change said temperature distribution of said tissue mass.
Claim 29
Dependent Claim
54 words
The system of claim 22 wherein each of said heat-emitting probe means includes a resistive heating wire wound in a cylindrical tubular form, the power applied to each of the resistive heating wires being controlled by said control means to produce at least a predetermined temperature along an outer surface of the probe means.
Claim 30
Independent Claim
111 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: implantable, heat-emitting probe means responsive to energy applied thereto for producing thermally conductive heat in a predetermined thermally conducted temperature distribution in said tissue mass when interstitially implanted in said tissue mass in a predetermined pattern; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the energy applied to said probe means for controlling the energy applied to said implantable, heat-emitting probe means to produce said predetermined thermally conducted temperature distribution in said tissue mass.
Claim 31
Independent Claim
111 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: implantable, heat-emitting probe means responsive to energy applied thereto for producing thermally conductive heat in a predetermined thermally conducted temperature distribution in said tissue mass when interstitially implanted in said tissue mass in a predetermined pattern; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the energy applied to said probe means for controlling the energy applied to said implantable, heat-emitting probe means to produce said predetermined thermally conducted temperature distribution in said tissue mass.
Claim 32
Independent Claim
145 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of interstitially implantable probes each including a heat-emitting element, each of said heat-emitting elements being responsive to energy applied thereto for producing thermally conductive heat in an individual, predetermined, thermally conducted temperature distribution in said tissue mass; said plurality of interstitially implantable probes also including a plurality of temperature sensors each for measuring temperature thereabout; control means responsive to the temperature measured about each of said temperature sensors and the energy applied to each of said heat-emitting elements when said plurality of probes are interstitially implanted in said tissue mass in a determinable pattern for controlling the energy applied to each of said heat-emitting elements to produce a combinational, predetermined, thermally conducted temperature distribution in said tissue mass resulting from the individual temperature distributions.
Claim 33
Independent Claim
145 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of interstitially implantable probes each including a heat-emitting element, each of said heat-emitting elements being responsive to energy applied thereto for producing thermally conductive heat in an individual, predetermined, thermally conducted temperature distribution in said tissue mass; said plurality of interstitially implantable probes also including a plurality of temperature sensors each for measuring temperature thereabout; control means responsive to the temperature measured about each of said temperature sensors and the energy applied to each of said heat-emitting elements when said plurality of probes are interstitially implanted in said tissue mass in a determinable pattern for controlling the energy applied to each of said heat-emitting elements to produce a combinational, predetermined, thermally conducted temperature distribution in said tissue mass resulting from the individual temperature distributions.
Claim 34
Independent Claim
103 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of interstitially implantable probes each having an outer surface and including a heat-emitting element therein for producing thermally conductive heat; each of said probes also including a temperature sensor for determining an outer surface temperature of the probe; and control means responsive to the outer surface temperature determined by each of said sensors and a thermally conducted temperature distribution of said tissue mass for controlling the energy applied to said heat-emitting elements to produce a predetermined minimum temperature throughout said tissue mass.
Claim 35
Independent Claim
103 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of interstitially implantable probes each having an outer surface and including a heat-emitting element therein for producing thermally conductive heat; each of said probes also including a temperature sensor for determining an outer surface temperature of the probe; and control means responsive to the outer surface temperature determined by each of said sensors and a thermally conducted temperature distribution of said tissue mass for controlling the energy applied to said heat-emitting elements to produce a predetermined minimum temperature throughout said tissue mass.
Claim 36
Independent Claim
111 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: heat-emitting probe means shaped for interstitial implantation in said tissue mass and responsive to energy applied thereto for radiating thermally conducted heat therefrom at a predetermined surface temperature; temperature sensor means for determining surface temperature of said probe means when implanted in said tissue mass; and control means responsive to the surface temperature determined by said temperature sensor means for controlling the energy applied to said heat-emitting probe means when interstitially implanted in said tissue mass in a predetermined pattern for producing a predetermined thermally conducted temperature distribution in said tissue mass.
Claim 37
Independent Claim
111 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass in a patient, comprising: heat-emitting probe means shaped for interstitial implantation in said tissue mass and responsive to energy applied thereto for radiating thermally conducted heat therefrom at a predetermined surface temperature; temperature sensor means for determining surface temperature of said probe means when implanted in said tissue mass; and control means responsive to the surface temperature determined by said temperature sensor means for controlling the energy applied to said heat-emitting probe means when interstitially implanted in said tissue mass in a predetermined pattern for producing a predetermined thermally conducted temperature distribution in said tissue mass.
Claim 38
Independent Claim
106 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass having a temperature distribution in a patient, comprising: interstitially implantable, heat-emitting probe means responsive to energy applied thereto for producing thermally conductive heat to change said temperature distribution of said tissue mass; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the energy applied to said probe means for controlling the energy applied to said interstitially implantable, heat-emitting probe means for producing thermally conductive heat to change said temperature distribution of said tissue mass.
Claim 39
Independent Claim
106 words
A system for producing volumetric, thermally conductive hyperthermia for the treatment of a tissue mass having a temperature distribution in a patient, comprising: interstitially implantable, heat-emitting probe means responsive to energy applied thereto for producing thermally conductive heat to change said temperature distribution of said tissue mass; temperature sensor means for measuring temperature thereabout when implanted in said tissue mass; and control means responsive to the temperature measured about said sensor means and the energy applied to said probe means for controlling the energy applied to said interstitially implantable, heat-emitting probe means for producing thermally conductive heat to change said temperature distribution of said tissue mass.
Claim 40
Independent Claim
85 words
A system for producing volumetric hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of interstitially implantable probes responsive to power applied thereto for producing thermally conductive heat in said tissue mass; sensor means for determining the thermal conductivity of said tissue mass; and control means responsive to the power applied to said probes and the thermal conductivity of said tissue mass for controlling the power applied to said probes to produce a predetermined minimum temperature throughout said tissue mass.
Claim 41
Independent Claim
85 words
A system for producing volumetric hyperthermia for the treatment of a tissue mass in a patient, comprising: a plurality of interstitially implantable probes responsive to power applied thereto for producing thermally conductive heat in said tissue mass; sensor means for determining the thermal conductivity of said tissue mass; and control means responsive to the power applied to said probes and the thermal conductivity of said tissue mass for controlling the power applied to said probes to produce a predetermined minimum temperature throughout said tissue mass.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-29 | 1996-09-28 | 1997-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-29 | 2000-09-28 | 2001-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-29 | 2004-09-28 | 2005-03-30 | $7700.00 | Window Closed / Lapsed |