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US5145674A
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Biologically-active compounds comprising a biologically-active anionic portion and a water-insoluble, inorganic cationic portion
Assignee: Dow Chemical Co
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Filing: 1991-04-30
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Granted: 1992-09-08
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Expires: 2011-04-30
Abstract
Abstract A biologically-active compound which includes an inorganic mixed metal cationic portion having anion exchange properties and an anionic portion containing a biologically-active anion. The mixed metal cationic portion can be an oxide, hydroxide, or both, and can be fully hydrated, partially hydrated, or not hydrated. The biologically-active anion can be, e.g., an antibiotic, an analgesic, an antimicrobial, a pharmaceutical, an antioxidant, or an agricultural chemical such as a herbicide or a pesticide. These biologically-active compounds can have controlled-release properties and can be produced by relatively simple processes, using for the cationic portion relatively common starting materials. These biologically-active compounds are useful, for example, in compositions to form pharmaceuticals, antioxidants, or herbicides, and can be incorporated into a polymeric material to form a shaped body, such as a plastic film which can be utilized to form bags for food storage or transportation. Also included are processes for making the biologically-active compounds.
Inventors
- 👤 George A. Lane
- 👤 Harold E. Rossow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60; A61K31/28; A61K31/33; A61K31/335; A61K31/365; A61K31/375; C; C07; C07C; C07C57/00; C07C57/30; C07C59/00; C07C59/40; C07C59/42; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07C59/70; C07F; C07F5/00; C07F5/06; C07F5/069; C07F7/00; C07F7/003
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
26 words
A biologically-active compound, comprising a biologically-active analgesic anion and a water-insoluble, inorganic cationic portion which contains two different metals, the cationic portion having anion exchange properties.
Claim 2
Dependent Claim
26 words
A biologically-active compound, comprising a biologically-active analgesic anion and a water-insoluble, inorganic cationic portion which contains two different metals, the cationic portion having anion exchange properties.
Claim 3
Dependent Claim
146 words
A biologically-active compound having the chemical formula: M.sup.1.sub.1-x Q.sup.a+1.sub.x O.sub.y (OH).sub.z A.sup.-1.sub.d A.sup.-2.sub.e A.sup.-3.sub.f A.sup.-4.sub.g. nH.sub.2 O wherein M is a metal element having a positive valence of a, Q is a metal element having a positive valence of a+1, A -1 , A -2 , A -3 , A -4 , are each exchangeable anions having a valence of -1, -2, -3, and -4, respectively, at least one of the exchangeable anions being an analgesic anion, a is 2, 3, 4, or 5, x is greater than zero and less than or equal to about 0.5, Y, z, d, e, f, and g are each greater than or equal to zero, 2Y+z is equal to a, d+2e+3F+4g is grater than zero and less than or equal to x, and n is greater than or equal to zero and less than or equal to about 10.
Claim 4
Dependent Claim
146 words
A biologically-active compound having the chemical formula: M.sup.1.sub.1-x Q.sup.a+1.sub.x O.sub.y (OH).sub.z A.sup.-1.sub.d A.sup.-2.sub.e A.sup.-3.sub.f A.sup.-4.sub.g. nH.sub.2 O wherein M is a metal element having a positive valence of a, Q is a metal element having a positive valence of a+1, A -1 , A -2 , A -3 , A -4 , are each exchangeable anions having a valence of -1, -2, -3, and -4, respectively, at least one of the exchangeable anions being an analgesic anion, a is 2, 3, 4, or 5, x is greater than zero and less than or equal to about 0.5, Y, z, d, e, f, and g are each greater than or equal to zero, 2Y+z is equal to a, d+2e+3F+4g is grater than zero and less than or equal to x, and n is greater than or equal to zero and less than or equal to about 10.
Claim 5
Dependent Claim
30 words
The biologically-active compound of claim 2, wherein M is selected from the group consisting of magnesium and aluminum and Q is selected from the group consisting of aluminum and titanium.
Claim 6
Dependent Claim
12 words
The biologically-active compound of claim 2 wherein the biologically-active anion is 2-(4-isobutylphenyl)propionate.
Claim 7
Dependent Claim
12 words
The biologically-active compound of claim 2, wherein the biologically-active anion is acetylsalicylate.
Claim 8
Dependent Claim
30 words
The biologically-active compound of claim 2, wherein the exchangeable anions include a biologically-non-active anion which has the capability of modifying the release of the biologically-active anion from the biologically-active compound.
Claim 9
Dependent Claim
28 words
The biologically-active compound of claim 6, wherein the biologically-non-active anion is selected from the group consisting of halides, hydroxides, nitrites, nitrates, phosphates, carbonates, sulfates, permanganates, carboxylates, and sulfonates.
Claim 10
Dependent Claim
146 words
A biologically-active compound having the chemical formula: M.sup.1.sub.1-x Q.sup.a+1.sub.x O.sub.y (OH).sub.z A.sup.-1.sub.d.nH.sub.2 O wherein M is a metal element having a positive valence of a and being selected from the group consisting of magnesium and aluminum, Q is a metal element having a positive valence of a+1 and being selected from the group consisting of aluminum and titanium, A -1 is an exchangeable anion having a valence of -1 and includes an anion selected from the group consisting of 2-(4-isobutylphenyl) propionate and acetylsalicylate a is 2 or 3, x is greater than zero and less than or equal to about 0.5, y and z are each greater than or equal to zero, 2Y+z is equal to a, d is greater than zero and less than or equal to x, and n is greater than or equal to zero and less than or equal to about 10.
Claim 11
Dependent Claim
146 words
A biologically-active compound having the chemical formula: M.sup.1.sub.1-x Q.sup.a+1.sub.x O.sub.y (OH).sub.z A.sup.-1.sub.d.nH.sub.2 O wherein M is a metal element having a positive valence of a and being selected from the group consisting of magnesium and aluminum, Q is a metal element having a positive valence of a+1 and being selected from the group consisting of aluminum and titanium, A -1 is an exchangeable anion having a valence of -1 and includes an anion selected from the group consisting of 2-(4-isobutylphenyl) propionate and acetylsalicylate a is 2 or 3, x is greater than zero and less than or equal to about 0.5, y and z are each greater than or equal to zero, 2Y+z is equal to a, d is greater than zero and less than or equal to x, and n is greater than or equal to zero and less than or equal to about 10.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-09-08 | 1996-03-09 | 1996-09-08 | $2000.00 | Window Closed / Lapsed |
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