US5143716A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
Assignee: ImaRx Therapeutics Inc
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Filing: 1991-02-01
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Granted: 1992-09-01
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Expires: 2011-02-01
Abstract
Abstract Methods of providing an image of the gastrointestional region of a patient and diagnosing the presence of any tumorous tissue in that region using contrast media comprising a combination of at least one polyphosphorylated aliphatic or polyphosphorylated alicyclic compound and at least one paramagnetic ion, wherein the aliphatic and alicyclic compounds comprise at least five carbon atoms, is described. Also described are diagnostic kits for gastrointestinal imaging which include the subject contrast media.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:51
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/126; A61K49/128; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
76 words
A method of providing an image of the gastrointestinal region of a patient comprising (a) administering to the patient, orally or rectally, a diagnostically effective amount of a contrast medium comprising (i) a polyphosphorylated compound selected from the group consisting of polyphosphorylated sugar alcohols, polyphosphorylated monosaccharides, and polyphosphorylated disaccharides comprising at least five carbon atoms, and (ii) a paramagnetic ion, and (b) scanning the patient using magnetic resonance imaging to obtain visible images of that region.
Claim 2
Independent Claim
76 words
A method of providing an image of the gastrointestinal region of a patient comprising (a) administering to the patient, orally or rectally, a diagnostically effective amount of a contrast medium comprising (i) a polyphosphorylated compound selected from the group consisting of polyphosphorylated sugar alcohols, polyphosphorylated monosaccharides, and polyphosphorylated disaccharides comprising at least five carbon atoms, and (ii) a paramagnetic ion, and (b) scanning the patient using magnetic resonance imaging to obtain visible images of that region.
Claim 3
Dependent Claim
58 words
A method according to claim 1 wherein said polyphosphorylated compound is selected from the group consisting of polyphosphorylated inositol, polyphosphorylated mannitol, polyphosphorylated sorbitol, polyphosphorylated pentaerythritol, polyphosphorylated galacitol, polyphosphorylated adonitol, polyphosphorylated arabitol, polyphosphorylated xylitol, polyphosphorylated glucose, polyphosphorylated fructose, polyphosphorylated mannose, polyphosphorylated idose, polyphosphorylated galactose, polyphosphorylated allose, polyphosphorylated altrose, polyphosphorylated arabinose, polyphosphorylated sucrose, polyphosphorylated maltose, polyphosphorylated cellobiose, and polyphosphorylated lactose.
Claim 4
Dependent Claim
13 words
A method according to claim 2 wherein said polyphosphorylated compound is inositol hexaphosphate.
Claim 5
Dependent Claim
22 words
A method according to claim 1 wherein said paramagnetic ion is selected from the group consisting of transition, lanthanide and actinide elements.
Claim 6
Dependent Claim
30 words
A method according to claim 4 wherein said paramagnetic ion is selected from the group consisting of Gd(III), Mn(II), Cu(II), Cr(III), Fe(II), Fe(III), Co(II), Er(II), Ni(II), Eu(III), Yb(III), and Dy(III).
Claim 7
Dependent Claim
20 words
A method according to claim 5 wherein said paramagnetic ion is selected from the group consisting of Fe(III) and Mn(II).
Claim 8
Dependent Claim
28 words
A method according to claim 1 wherein said polyphosphorylated compound is inositol hexaphosphate and wherein said paramagnetic ion is selected from the group consisting of Fe(III) and Mn(II).
Claim 9
Dependent Claim
15 words
A method according to claim 1 wherein said polyphosphorylated compound is a polyphosphorylated sugar alcohol.
Claim 10
Dependent Claim
14 words
A method according to claim 1 wherein said polyphosphorylated compound is a polyphosphorylated monosaccharide.
Claim 11
Dependent Claim
14 words
A method according to claim 1 wherein said polyphosphorylated compound is a polyphosphorylated disaccharide.
Claim 12
Dependent Claim
56 words
A method according to claim 1 wherein said polyphosphorylated compound is selected from the group consisting of polyphosphorylated mannitol, polyphosphorylated sorbitol, polyphosphorylated pentaerythritol, polyphosphorylated galacitol, polyphosphorylated adonitol, polyphosphorylated arabitol, polyphosphorylated xylitol, polyphosphorylated glucose, polyphosphorylated fructose, polyphosphorylated mannose, polyphosphorylated idose, polyphosphorylated galactose, polyphosphorylated allose, polyphosphorylated altrose, polyphosphorylated arabinose, polyphosphorylated sucrose, polyphosphorylated maltose, polyphosphorylated cellobiose, and polyphosphorylated lactose.
Claim 13
Independent Claim
83 words
A method for diagnosing the presence of diseased tissue in the gastrointestinal region of a patient comprising (a) administering to the patient, orally or rectally, a diagnostically effective amount of a contrast medium comprising (i) a polyphosphorylated compound selected from the group consisting of polyphosphorylated sugar alcohols, polyphosphorylated monosaccharides, and polyphosphorylated disaccharides comprising at leave five carbon atoms, and (ii) a paramagnetic ion, and (b) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue in the patient.
Claim 14
Independent Claim
83 words
A method for diagnosing the presence of diseased tissue in the gastrointestinal region of a patient comprising (a) administering to the patient, orally or rectally, a diagnostically effective amount of a contrast medium comprising (i) a polyphosphorylated compound selected from the group consisting of polyphosphorylated sugar alcohols, polyphosphorylated monosaccharides, and polyphosphorylated disaccharides comprising at leave five carbon atoms, and (ii) a paramagnetic ion, and (b) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue in the patient.
Claim 15
Dependent Claim
58 words
A method according to claim 12 wherein said polyphosphorylated compound is selected from the group consisting of polyphosphorylated inositol, polyphosphorylated mannitol, polyphosphorylated sorbitol, polyphosphorylated pentaerythritol, polyphosphorylated galacitol, polyphosphorylated adonitol, polyphosphorylated arabitol, polyphosphorylated xylitol, polyphosphorylated glucose, polyphosphorylated fructose, polyphosphorylated mannose, polyphosphorylated idose, polyphosphorylated galactose, polyphosphorylated allose, polyphosphorylated altrose, polyphosphorylated arabinose, polyphosphorylated sucrose, polyphosphorylated maltose, polyphosphorylated cellobiose, and polyphosphorylated lactose.
Claim 16
Dependent Claim
13 words
A method according to claim 13 wherein said polyphosphorylated compound is inositol hexaphosphate.
Claim 17
Dependent Claim
22 words
A method according to claim 12 wherein said paramagnetic ion is selected from the group consisting of transition, lanthanide and actinide elements.
Claim 18
Dependent Claim
30 words
A method according to claim 15 wherein said paramagnetic ion is selected from the group consisting of Gd(III), Mn(II), Cu(II), Cr(III), Fe(II), Fe(III), Co(II), Er(II), Ni(II), Eu(III), Yb(III), and Dy(III).
Claim 19
Dependent Claim
20 words
A method according to claim 16 wherein said paramagnetic ion is selected from the group consisting of Fe(III) and Mn(II).
Claim 20
Dependent Claim
28 words
A method according to claim 12 wherein said polyphosphorylated compound is inositol hexaphosphate and wherein said paramagnetic ion is selected from the group consisting of Fe(III) and Mn(II).
Claim 21
Dependent Claim
15 words
A method according to claim 12 wherein said polyphosphorylated compound is a polyphosphorylated sugar alcohol.
Claim 22
Dependent Claim
14 words
A method according to claim 12 wherein said polyphosphorylated compound is a polyphosphorylated monosaccharide.
Claim 23
Dependent Claim
14 words
A method according to claim 12 wherein said polyphosphorylated compound is a polyphosphorylated disaccharide.
Claim 24
Dependent Claim
56 words
A method according to claim 12 wherein said polyphosphorylated compound is selected from the group consisting of polyphosphorylated mannitol, polyphosphorylated sorbitol, polyphosphorylated pentaerythritol, polyphosphorylated galacitol, polyphosphorylated adonitol, polyphosphorylated arabitol, polyphosphorylated xylitol, polyphosphorylated glucose, polyphosphorylated fructose, polyphosphorylated mannose, polyphosphorylated idose, polyphosphorylated galactose, polyphosphorylated allose, polyphosphorylated altrose, polyphosphorylated arabinose, polyphosphorylated sucrose, polyphosphorylated maltose, polyphosphorylated cellobiose, and polyphosphorylated lactose.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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