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US5132101A
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Acetylene-cumulene porphycene compounds for photodynamic therapy
Assignee: Cytopharm Inc
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Filing: 1990-09-06
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Granted: 1992-07-21
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Expires: 2010-09-06
Abstract
Abstract Dihydro- and tetrahydro-acetylene-cumulene porphycene compounds having the structure shown below <IMAGE> <IMAGE> are useful as photogynamic therapy agents.
Inventors
- 👤 Emanuel Vogel
- 👤 Alexander D. Cross
- 👤 Norbert Jux
- 👤 Eduardo Rodriguez-Val
- 👤 Stefan Boehm
- 👤 Wolfgang Hennig
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:18
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/22; A; A61; A61K; A61K41/00; A61K41/0057; A61K41/0076
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
42 words
An acetylene-cumulene porphycene compound having the structure shown below: ##STR13## wherein R is C 6-20 aryl, straight-chain or branched C 1-20 alkyl or alkoxyalkyl of the formula R'--O--(CH 2 ) x --, where R' is C 1-6 alkyl and x is 1-6.
Claim 2
Dependent Claim
42 words
An acetylene-cumulene porphycene compound having the structure shown below: ##STR13## wherein R is C 6-20 aryl, straight-chain or branched C 1-20 alkyl or alkoxyalkyl of the formula R'--O--(CH 2 ) x --, where R' is C 1-6 alkyl and x is 1-6.
Claim 3
Dependent Claim
11 words
The compound of claim 1, wherein R is C 1-10 alkyl.
Claim 4
Dependent Claim
11 words
The compound of claim 1, wherein R is C 1-6 alkyl.
Claim 5
Dependent Claim
41 words
A compound having the structure shown below: ##STR14## wherein R is a C 6-20 aryl, straight-chain or branched C 1-20 alkyl or alkoxyalkyl of the formula R'--O--(CH 2 ) x --, where R' is C 1-6 alkyl and x is 1-6.
Claim 6
Dependent Claim
41 words
A compound having the structure shown below: ##STR14## wherein R is a C 6-20 aryl, straight-chain or branched C 1-20 alkyl or alkoxyalkyl of the formula R'--O--(CH 2 ) x --, where R' is C 1-6 alkyl and x is 1-6.
Claim 7
Dependent Claim
11 words
The compound of claim 4, wherein R is C 1-10 alkyl.
Claim 8
Dependent Claim
11 words
The compound of claim 5, wherein R is C 1-6 alkyl.
Claim 9
Dependent Claim
52 words
A pharmaceutical composition comprising an effective amount of a compound having the structure shown below: ##STR15## wherein R is C 6-20 aryl, straight-chain or branched C 1-20 alkyl or alkoxyalkyl of the formula R'--O--(CH 2 ) x -- where R' is C 1-6 alkyl, x is 1-6, and a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
52 words
A pharmaceutical composition comprising an effective amount of a compound having the structure shown below: ##STR15## wherein R is C 6-20 aryl, straight-chain or branched C 1-20 alkyl or alkoxyalkyl of the formula R'--O--(CH 2 ) x -- where R' is C 1-6 alkyl, x is 1-6, and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
11 words
The composition of claim 7, wherein R is C 1-10 alkyl.
Claim 12
Dependent Claim
11 words
The composition of claim 8, wherein R is C 1-6 alkyl.
Claim 13
Dependent Claim
19 words
The composition of claim 7, wherein said carrier is a penetrating solvent which enhances percutaneous penetration of said compound.
Claim 14
Independent Claim
77 words
A method of photodynamic therapy, comprising the steps of administering to a mammal in need thereof, an effective amount of a having the formula shown below: ##STR16## wherein R is C 6-20 aryl, straight-chain or branched C 1-20 alkyl, or alkoxyalkyl of the formula R'--O--(CH 2 ) x --, where R' is C 1-6 alkyl and x is 1-6, and irradiating said animal with light at a wavelength in the absorption spectrum of said reduced acetylene-cumulene porphycene.
Claim 15
Independent Claim
77 words
A method of photodynamic therapy, comprising the steps of administering to a mammal in need thereof, an effective amount of a having the formula shown below: ##STR16## wherein R is C 6-20 aryl, straight-chain or branched C 1-20 alkyl, or alkoxyalkyl of the formula R'--O--(CH 2 ) x --, where R' is C 1-6 alkyl and x is 1-6, and irradiating said animal with light at a wavelength in the absorption spectrum of said reduced acetylene-cumulene porphycene.
Claim 16
Dependent Claim
11 words
The method of claim 11, wherein said administering is topical administration.
Claim 17
Dependent Claim
15 words
The method of claim 11, wherein said administering is enteral, parenteral, intramuscular or oral administration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-07-21 | 1996-01-20 | 1996-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-21 | 2000-01-20 | 2000-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-21 | 2004-01-20 | 2004-07-21 | $7700.00 | Window Closed / Lapsed |