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US5118528A
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Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles
Assignee: Centre National de la Recherche Scientifique
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Filing: 1990-10-04
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Granted: 1992-06-02
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Expires: 2010-10-04
Abstract
Abstract The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance, and (4) is desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to produce a powder of nanoparticles.
Inventors
- 👤 Curt Fessi
- 👤 Jean-Philippe Devissaguet
- 👤 Francis Puisieux
- 👤 Curt Thies
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K9/5146; A61K9/5153; A61K9/5192; C; C08; C08J; C08J3/00; C08J3/12; C08J3/14; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/773; Y10S977/775; Y10S977/84; Y10S977/849; Y10S977/86; Y10S977/875; Y10S977/895; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
172 words
A process for the preparation of dispersible colloidal systems of a substance in the form of spherical particles of the matrix type and of a size less than 500 nm (nanoparticles), comprising: combining (1) a first liquid phase consisting essentially of a solution of a film-forming material and a biologically active substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, and (2) a greater volume of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the film-forming material and biologically active substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the film-forming material and biologically active substance being miscible in all proportions with the solvent or mixture of solvents for the film-forming material and biologically active substance; thereby substantially instantaneously to precipitate from said solvent and said non-solvent composite particles of said film-forming material and biologically active substance to produce a colloidal suspension of composite nanoparticles.
Claim 2
Dependent Claim
172 words
A process for the preparation of dispersible colloidal systems of a substance in the form of spherical particles of the matrix type and of a size less than 500 nm (nanoparticles), comprising: combining (1) a first liquid phase consisting essentially of a solution of a film-forming material and a biologically active substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, and (2) a greater volume of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the film-forming material and biologically active substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the film-forming material and biologically active substance being miscible in all proportions with the solvent or mixture of solvents for the film-forming material and biologically active substance; thereby substantially instantaneously to precipitate from said solvent and said non-solvent composite particles of said film-forming material and biologically active substance to produce a colloidal suspension of composite nanoparticles.
Claim 3
Dependent Claim
48 words
The process according to claim 1, further comprising removing at least a portion of the solvent or the mixture of solvents and of the non-solvent or mixture of non-solvents thereby to produce a colloidal suspension of nanoparticles of a desired concentration, or to produce a powder of nanoparticles.
Claim 4
Dependent Claim
17 words
The process according to claim 2, wherein said solvents and non-solvents are substantially completely removed by lyophilization.
Claim 5
Dependent Claim
21 words
The process according to claim 1, wherein said combining step comprises adding said first liquid phase to said second liquid phase.
Claim 6
Dependent Claim
28 words
The process according to claim 1, wherein a lesser amount of non-solvent is used to form said second phase than solvent used to prepare said first liquid phase.
Claim 7
Dependent Claim
21 words
The process according to claim 1, wherein said colloidal suspension comprises 0.1 to 10% by weight of at least one surfactant.
Claim 8
Dependent Claim
27 words
The process according to claim 6, wherein said at least one surfactant is present in said colloidal suspension in an amount of 0.2 to 2% by weight.
Claim 9
Dependent Claim
13 words
The process according to claim 1, wherein said film-forming material is a polymer.
Claim 10
Dependent Claim
25 words
The process according to claim 8, wherein said polymer is present in said first liquid phase in an amount of 0.1 to 10% by weight.
Claim 11
Dependent Claim
19 words
The process according to claim 9, wherein the concentration of the polymer is between 0.2 and 2% by weight.
Claim 12
Dependent Claim
19 words
The process according to claim 8, wherein a second substance is bound to the nanoparticles of said colloidal suspension.
Claim 13
Dependent Claim
15 words
The process according to claim 11, wherein said second substance is a biologically active substance.
Claim 14
Dependent Claim
15 words
The process according to claim 1, wherein said biologically active substance is a fatty substance.
Claim 15
Dependent Claim
16 words
The process according to claim 1, wherein the nanoparticles have a diameter of about 200 nm.
Claim 16
Dependent Claim
144 words
A process for the preparation of dispersible colloidal systems of a substance in the form of spherical particles of the matrix type and of a size less than 500 nm (nanoparticles), comprising: combining (1) a first liquid phase consisting essentially of a solution of a polymer in a solvent or in a mixture of solvents to which may be added one or more surfactants, and (2) a greater volume of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the polymer and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the polymer being miscible in all proportions with the solvent or mixture of solvents for the polymer; thereby substantially instantaneously to precipitate from said solvent and said non-solvent particles of said polymer to produce a colloidal suspension of nanoparticles.
Claim 17
Dependent Claim
144 words
A process for the preparation of dispersible colloidal systems of a substance in the form of spherical particles of the matrix type and of a size less than 500 nm (nanoparticles), comprising: combining (1) a first liquid phase consisting essentially of a solution of a polymer in a solvent or in a mixture of solvents to which may be added one or more surfactants, and (2) a greater volume of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the polymer and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the polymer being miscible in all proportions with the solvent or mixture of solvents for the polymer; thereby substantially instantaneously to precipitate from said solvent and said non-solvent particles of said polymer to produce a colloidal suspension of nanoparticles.
Claim 18
Dependent Claim
12 words
The process according to claim 15, wherein the polymer is polylactic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-02 | 1995-12-02 | 1996-06-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-02 | 1999-12-02 | 2000-06-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-02 | 2003-12-02 | 2004-06-02 | $7700.00 | Window Closed / Lapsed |