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US5104403A
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Vascular prosthesis containing in the wall microcapsules, including hormone-producing cells
Assignee: GIOVANNI BROTZU PIAZZA GARIBALDI
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Filing: 1990-07-05
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Granted: 1992-04-14
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Expires: 2010-07-05
Abstract
Abstract A vascular prosthesis having a low porosity outer material such as FTFE, and an inner synthetic tubular mesh. Semi-permeable microcapsules that contain hormone-producing cells, are placed between the outer material and the inner mesh. The microcapsules are preferably made of polysaccharides or amino-acid polymers.
Inventors
- 👤 Giovanni Brotzu
- 👤 Riccardo Calafiore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:03
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/54; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/40; A61L2300/43; A61L2300/60; A61L2300/62; A61L2300/622; A61L2300/64
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
80 words
A vascular prosthesis comprising an outer material having a low porosity and an inner tubular porous mesh of synthetic material said porous mesh having a porosity to allow oxygen and hormones to pass therethrough; and microcapsules disposed between said outer material and said inner tubular mesh, said microcapsules being made of a semi-permeable material and containing hormone-producing cells whereby hematic flow through said vascular prosthesis allows for metabolism of the cells and circulation of the hormones secreted by said cells.
Claim 2
Dependent Claim
80 words
A vascular prosthesis comprising an outer material having a low porosity and an inner tubular porous mesh of synthetic material said porous mesh having a porosity to allow oxygen and hormones to pass therethrough; and microcapsules disposed between said outer material and said inner tubular mesh, said microcapsules being made of a semi-permeable material and containing hormone-producing cells whereby hematic flow through said vascular prosthesis allows for metabolism of the cells and circulation of the hormones secreted by said cells.
Claim 3
Dependent Claim
15 words
The prosthesis according to claim 10, wherein said tubular mesh comprises polyester or polytetrafluoroethylene fibers.
Claim 4
Dependent Claim
20 words
The prosthesis according to claim 10, wherein said tubular mesh has an internal diameter of between 4 and 14 mm.
Claim 5
Dependent Claim
23 words
The prosthesis according to claim 10, wherein the free space between the filaments of said tubular mesh is between 10 and 300 micron.
Claim 6
Dependent Claim
12 words
The prosthesis according to claim 1, wherein said outer material comprises PTFE.
Claim 7
Dependent Claim
18 words
The prosthesis according to claim 1, wherein said microcapsules are comprised of a polysaccharide or an amino-acid polymer.
Claim 8
Dependent Claim
13 words
The prosthesis according to claim 1, wherein said microcapsules contain Langerhans islands cells.
References Cited (Backward Citations)
US4409331A
Cited
EP0393788A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-14 | 1995-10-14 | 1996-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-14 | 1999-10-14 | 2000-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-14 | 2003-10-14 | 2004-04-14 | $7700.00 | Window Closed / Lapsed |