US5034265A
Expired / Lapsed
US
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Plasma gas discharge treatment for improving the compatibility of biomaterials
Assignee: Washington Research Foundation
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Filing: 1989-08-21
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Granted: 1991-07-23
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Expires: 2009-08-21
Abstract
Abstract A method of treating articles to improve their biocompatibility is disclosed. A polymeric substrate material is positioned within a reactor vessel and exposed to plasma gas discharge in the presence of an atmosphere of an inert gas and then in the presence of an organic gas, such as a fluorinated hydrocarbon gas, which forms a thin, biocompatible surface covalently bonded to the surface of the substrate. The method is particularly useful in the treatment of vascular graft materials to produce grafts that are both thrombi- and emboli-resistant.
Inventors
- 👤 Allan S. Hoffman
- 👤 Andrew M. Garfinkle
- 👤 Buddy D. Ratner
- 👤 Stephen R. Hanson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:14
CPC Classifications
B; B05; B05D; B05D1/00; B05D1/62; A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L; A61L27/00; A61L27/50; A61L27/507; A61L33/00; A61L33/0076; A61L33/0088; A61L33/0094; B05D3/00; B05D3/14; B05D3/141; B05D3/142; C; C08; C08L; C08L27/00; C08L27/02; C08L27/12; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921; Y10T; Y10T428/00; Y10T428/31504; Y10T428/3154; Y10T428/31544; Y10T442/00; Y10T442/20; Y10T442/2549
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
119 words
A method of making a vascular prosthesis from a woven or knit polymeric substrate material whose surface exposed to blood is treated to render the vascular prosthesis both thrombi- and emboli-resistant, comprising: exposing the surface of the woven or knit substrate material to be exposed to blood to a radio frequency plasma gas discharge in the presence of a fluorinated hydrocarbon gas, wherein the fluorinated hydrocarbon gas forms a thin coating on the surface exposed to blood of the woven or knit polymeric substrate, said thin coating characterized as highly cross-linked, covalently bound to the woven or knit polymeric substrate material, and not changing the mechanical behavior of the woven or knit polymeric substrate material or its surface texture.
Claim 2
Independent Claim
119 words
A method of making a vascular prosthesis from a woven or knit polymeric substrate material whose surface exposed to blood is treated to render the vascular prosthesis both thrombi- and emboli-resistant, comprising: exposing the surface of the woven or knit substrate material to be exposed to blood to a radio frequency plasma gas discharge in the presence of a fluorinated hydrocarbon gas, wherein the fluorinated hydrocarbon gas forms a thin coating on the surface exposed to blood of the woven or knit polymeric substrate, said thin coating characterized as highly cross-linked, covalently bound to the woven or knit polymeric substrate material, and not changing the mechanical behavior of the woven or knit polymeric substrate material or its surface texture.
Claim 3
Dependent Claim
35 words
The method of claim 1 wherein the fluorinated hydrocarbon gas is present at a pressure of from 0.1 to 1.0 torr, and wherein the radio frequency plasma discharge energy is from 5 to 100 watts.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the fluorinated hydrocarbon gas is tetrafluoroethylene.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the woven polymeric substrate material is a woven or knit polyethylene terephthalate.
Claim 6
Dependent Claim
92 words
A surface modified vascular graft material whose treated surface, when exposed to blood, is both thrombi- and emboli-resistant over extended periods of time, comprising: a woven or knit polyethylene terephthalate substrate material having a thin, covalently bonded coating on the treated surface, wherein the coating consists essentially of a highly cross-linked fluorocarbon polymer resulting from a radio frequency plasma discharge polymerization process conducted in a fluorinated hydrocarbon gaseous atmosphere, and wherein the coating does not change the mechanical behavior of the woven or knit polyethylene terephthalate substrate material or its surface texture.
Claim 7
Dependent Claim
92 words
A surface modified vascular graft material whose treated surface, when exposed to blood, is both thrombi- and emboli-resistant over extended periods of time, comprising: a woven or knit polyethylene terephthalate substrate material having a thin, covalently bonded coating on the treated surface, wherein the coating consists essentially of a highly cross-linked fluorocarbon polymer resulting from a radio frequency plasma discharge polymerization process conducted in a fluorinated hydrocarbon gaseous atmosphere, and wherein the coating does not change the mechanical behavior of the woven or knit polyethylene terephthalate substrate material or its surface texture.
Claim 8
Dependent Claim
18 words
The surface modified vascular graft material of claim 5 wherein the fluorinated hydrocarbon gaseous atmosphere consists of tetrafluoroethylene.
Claim 9
Dependent Claim
46 words
The surface modified vascular graft material of claim 5 wherein the fluorinated hydrocarbon gaseous atmosphere has a pressure in the reactor vessel from 0.1 to 1.0 torr, and wherein the electric glow discharge polymerization process uses a frequency energy range of from 5 to 50 watts.
Claim 10
Independent Claim
126 words
A method for making a surface modified woven or knit substrate material characterized by having a coated surface, when exposed to blood, is both thrombi- and emboli-resistant over extended periods of time, comprising: exposing a surface of the woven or knit substrate material to a plasma gas discharge in the presence of an inert gas to etch and activate the surface of the woven substrate; and exposing the etched and activated surface of the woven or knit substrate to a plasma gas discharge in the presence of a fluorinated hydrocarbon gas, wherein the surface becomes coated by a thin, covalently bound fluorocarbon polymer, characterized by being highly cross-linked and by not changing the mechanical behavior of the woven or knit substrate material or its surface texture.
Claim 11
Independent Claim
126 words
A method for making a surface modified woven or knit substrate material characterized by having a coated surface, when exposed to blood, is both thrombi- and emboli-resistant over extended periods of time, comprising: exposing a surface of the woven or knit substrate material to a plasma gas discharge in the presence of an inert gas to etch and activate the surface of the woven substrate; and exposing the etched and activated surface of the woven or knit substrate to a plasma gas discharge in the presence of a fluorinated hydrocarbon gas, wherein the surface becomes coated by a thin, covalently bound fluorocarbon polymer, characterized by being highly cross-linked and by not changing the mechanical behavior of the woven or knit substrate material or its surface texture.
Claim 12
Dependent Claim
18 words
The method of claim 8 wherein the inert gas is argon and the fluorinated hydrocarbon gas is tetrafluoroethylene.
Claim 13
Dependent Claim
17 words
The method of claim 8 wherein the woven or knit substrate is a fabric of polyethylene terephthalate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-22 | 1995-01-21 | 1995-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-22 | 1999-01-21 | 1999-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-22 | 2003-01-21 | 2003-07-23 | $7700.00 | Window Closed / Lapsed |