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US5030722A
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Odorant-binding protein from rat
Assignee: Johns Hopkins University
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Filing: 1988-03-30
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Granted: 1991-07-09
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Expires: 2008-03-30
Abstract
Abstract DNA molecules are taught which code for an odorant-binding protein which is synthesized solely in the lateral nasal gland. This protein, because of the broad range of odorants which it binds, can be used in many techniques for trapping odorants in either a liquid or solid medium. This protein bears some structural homology with other carriers of small lipophilic molecules from many other species; the carriers are known to transport specific lipophilic molecules.
Inventors
- 👤 Solomon H. Snyder
- 👤 Jonathan Pevsner
- 👤 Randall Reed
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:49
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/645; C07K14/705
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
46 words
A DNA molecule which is free of introns which encodes an odorant-binding protein, wherein said sequence hybridizes with the DNA sequence of FIG. 1 and encodes a protein with odorant binding activity, wherein odorant binding activity is defined by the ability to specifically bind 2-isobutyl-3-methoxypyrazine (IBMP).
Claim 2
Dependent Claim
46 words
A DNA molecule which is free of introns which encodes an odorant-binding protein, wherein said sequence hybridizes with the DNA sequence of FIG. 1 and encodes a protein with odorant binding activity, wherein odorant binding activity is defined by the ability to specifically bind 2-isobutyl-3-methoxypyrazine (IBMP).
Claim 3
Dependent Claim
22 words
A DNA sequence of claim 1 which encodes a rat odorant binding protein having the amino acid sequence shown in FIG. 1.
Claim 4
Dependent Claim
16 words
The DNA sequence of claim 2 which has the nucleic acid sequence shown in FIG. 1.
Claim 5
Dependent Claim
14 words
The DNA sequence of claim 1 which is operably linked to a transcriptional promoter.
Claim 6
Dependent Claim
16 words
The DNA sequence of claim 1 which is operably linked to a heterologous translational start site.
Claim 7
Dependent Claim
16 words
The DNA sequence of claim 5 in which the transcriptional promoter is functional in E. coli.
Claim 8
Dependent Claim
16 words
The DNA sequence of claim 5, in which the transcriptional promoter is functional in eukaryotic cells.
References Cited (Backward Citations)
US4578355A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-08 | 1995-01-07 | 1995-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-08 | 1999-01-07 | 1999-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-08 | 2003-01-07 | 2003-07-09 | $7700.00 | Window Closed / Lapsed |