Patent US4990132A successfully refreshed from Google Patents.
US4990132A
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Method and apparatus for plasmapheresis
Assignee: OMEGA MEDICINTEKNIK A SWEDISH CORP AB
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Filing: 1987-05-13
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Granted: 1991-02-05
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Expires: 2007-05-13
Abstract
Abstract A method for plasmapheresis includes withdrawal of a quantity of blood from a blood donor to an annular primary container forming part of a closed flexible processing assembly positioned in a processing space provided in a centrifuge rotor and conformed to the processing assembly. During the withdrawal, the rotor is caused to perform an oscillating movement for agitating the blood whereupon the blood is centrifuged in the primary container to be separated into blood cells and plasma. While the centrifugation is going on, the primary container is compressed to expel the plasma fraction to a secondary container. Liquid diluent is then fed to the primary container to resuspend the blood cell fraction while agitation is again accomplished by oscillating the rotor, whereupon the blood cell fraction is returned to the blood donor. The apparatus is a closed flexible processing assembly for use in carrying out the method according to the invention and includes an annular primary container, a secondary container positioned in the central region of the annular primary container, a collapsible connecting duct connecting the portion of the primary container closest to the center of rotation with the secondary container, and a flexible tube connected to the primary container.
Inventors
- 👤 Peter Unger
- 👤 Eric Westberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:02
CPC Classifications
B; B04; B04B; B04B5/00; B04B5/04; B04B5/0407; B04B5/0428; A; A61; A61M; A61M1/00; A61M1/14; A61M1/30; A61M1/301; A61M1/304; A61M1/34; A61M1/3496; A61M1/36; A61M1/3693; A61M1/3696; A61M1/3698; A61M1/02; A61M1/025; G; G01; G01N; G01N1/00; G01N1/28; G01N1/40; G01N1/4022; G01N2001/4027; G01N35/00; G01N2035/00465; G01N2035/00495
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
140 words
A method for carrying out plasmapheresis comprising the steps of: withdrawing a quantity of blood from a blood donor to an annular primary container forming part of a closed flexible processing assembly positioned in a processing space in the rotor of a centrifuge, said processing space being conformed to the processing assembly; agitating the motor during withdrawal of the blood and thereby also agitating the blood; centrifuging the blood in the primary container and thereby separating the blood into blood cells and plasma; compressing the primary container during centrifuging and thereby expelling the plasma to a secondary container disposed in a central region of the annular primary container; simultaneously feeding liquid dilutent to the primary container and agitating said primary container with the rotor and thereby resuspending said blood cells, and returning the suspended blood cells to the blood donor.
Claim 2
Independent Claim
140 words
A method for carrying out plasmapheresis comprising the steps of: withdrawing a quantity of blood from a blood donor to an annular primary container forming part of a closed flexible processing assembly positioned in a processing space in the rotor of a centrifuge, said processing space being conformed to the processing assembly; agitating the motor during withdrawal of the blood and thereby also agitating the blood; centrifuging the blood in the primary container and thereby separating the blood into blood cells and plasma; compressing the primary container during centrifuging and thereby expelling the plasma to a secondary container disposed in a central region of the annular primary container; simultaneously feeding liquid dilutent to the primary container and agitating said primary container with the rotor and thereby resuspending said blood cells, and returning the suspended blood cells to the blood donor.
Claim 3
Dependent Claim
59 words
A method according to claim 1, wherein the step of centrifuging the blood is further defined by centrifuging the blood at a first speed with a collapsible connecting duct between the primary container and the secondary container being closed and increasing the rotational speed of the rotor to a second rotational speed at which the connecting duct is open.
Claim 4
Dependent Claim
30 words
A method according to claim 1, comprising the additional step of subjecting the processing space of the rotor to a vacuum during the withdrawal of blood to the primary container.
Claim 5
Dependent Claim
29 words
A method according to claim 1, comprising the additional step of pressurizing the processing space of the rotor during the returning of the blood cells to the blood donor.
Claim 6
Dependent Claim
161 words
In a closed flexible processing assembly for use in carrying out plasmapheresis by withdrawing a quantity of blood from a blood donor into a primary container, centrifugally separating the blood in the primary container into a plasma fraction and a blood cell fraction, transferring the plasma fraction from the primary container into a secondary container, and returning the blood cell fraction from the primary container to the donor, the improvement of said processing assembly being adapted to be received in a processing space in a centrifuge rotor and comprising the following: an annular primary container; a secondary container surrounded by the primary container; a tubular connecting duct providing communication of the radially inner portion of the primary container with the secondary container; and a flexible tube connected to the primary container for conveying blood into the primary container; wherein said primary and secondary containers comprise pieces of plastic foil joined together by an outer annular joint and an inner annular joint.
Claim 7
Dependent Claim
161 words
In a closed flexible processing assembly for use in carrying out plasmapheresis by withdrawing a quantity of blood from a blood donor into a primary container, centrifugally separating the blood in the primary container into a plasma fraction and a blood cell fraction, transferring the plasma fraction from the primary container into a secondary container, and returning the blood cell fraction from the primary container to the donor, the improvement of said processing assembly being adapted to be received in a processing space in a centrifuge rotor and comprising the following: an annular primary container; a secondary container surrounded by the primary container; a tubular connecting duct providing communication of the radially inner portion of the primary container with the secondary container; and a flexible tube connected to the primary container for conveying blood into the primary container; wherein said primary and secondary containers comprise pieces of plastic foil joined together by an outer annular joint and an inner annular joint.
Claim 8
Dependent Claim
27 words
A processing assembly according to claim 5, wherein said tubular connecting duct includes a check valve permitting liquid flow from the primary container to the secondary container.
Claim 9
Dependent Claim
24 words
A processing assembly according to claim 5, wherein said inner annular joint is perforated whereby said containers can readily by disconnected from one another.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-04 | 1994-08-06 | 1995-02-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-04 | 1998-08-06 | 1999-02-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-04 | 2002-08-06 | 2003-02-05 | $7700.00 | Window Closed / Lapsed |