US4981692A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic treatment by intramammary infusion
Assignee: Elan Pharmaceuticals LLC
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Filing: 1987-08-18
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Granted: 1991-01-01
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Expires: 2007-08-18
Abstract
Abstract A method of treating, by intramammary infusion of liposomes, Brucella spp. infections in an animal by administration of a therapeutically effective amount of aminoglycoside in liposome form, also being a method of administering a therapeutic agent in liposome form to a proximal mammary lymph node or mammary tissue of an animal.
Inventors
- 👤 Mircea Popescu
- 👤 Christine E. Swenson
- 👤 Sterling C. Johnson
- 👤 Robert P. Lenk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:28
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/10; A61K9/127; C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/226; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
23 words
A method of treating infections in an animal by administration of a therapeutically effective amount of aminoglycoside in liposome form by intramammary infusion.
Claim 2
Independent Claim
23 words
A method of treating infections in an animal by administration of a therapeutically effective amount of aminoglycoside in liposome form by intramammary infusion.
Claim 3
Independent Claim
25 words
A method of treating Brucella spp. infections in an animal by administration of a therapeutically effective amount of aminoglycoside in liposome form by intramammary infusion.
Claim 4
Independent Claim
25 words
A method of treating Brucella spp. infections in an animal by administration of a therapeutically effective amount of aminoglycoside in liposome form by intramammary infusion.
Claim 5
Dependent Claim
10 words
The method of claim 2 wherein the aminoglycoside is streptomycin.
Claim 6
Dependent Claim
20 words
The method of claim 3 wherein the streptomycin is administered at from about 35 to about 50 mg/kg body weight.
Claim 7
Dependent Claim
21 words
The method of claim 3 wherein the streptomycin is administered in a dose regimen of about 2 to about 5 doses.
Claim 8
Dependent Claim
20 words
The method of claim 3 wherein the liposomes comprise at least about equal amounts of lipid and streptomycin sulfate (w/w).
Claim 9
Dependent Claim
16 words
The method of claim 2 further comprising administration of a therapeutically effective amount of a tetracycline.
Claim 10
Dependent Claim
10 words
The method of claim 7 wherein the tetracycline is oxytetracycline.
Claim 11
Dependent Claim
20 words
The method of claim 8 wherein the oxytetracycline is administered at from about 10 to about 30 mg/kg body weight.
Claim 12
Dependent Claim
12 words
The method of claim 2 wherein the liposomes are stable plurilamellar vesicles.
Claim 13
Dependent Claim
10 words
The method of claim 10 wherein the liposomes comprise phosphatidylcholine.
Claim 14
Independent Claim
26 words
A method of administering a therapeutic agent to a proximal mammary lymph node of an animal comprising intramammary infusion of said therapeutic agent in liposome form.
Claim 15
Independent Claim
26 words
A method of administering a therapeutic agent to a proximal mammary lymph node of an animal comprising intramammary infusion of said therapeutic agent in liposome form.
Claim 16
Dependent Claim
13 words
The method of claim 12 wherein the therapeutic agent is an anti-infective agent.
Claim 17
Dependent Claim
12 words
The method of claim 13 wherein the anti-infective agent is an imidazole.
Claim 18
Dependent Claim
12 words
The method of claim 13 wherein the anti-infective agent is a β-lactam.
Claim 19
Dependent Claim
13 words
The method of claim 12 wherein the therapeutic agent is an antineoplastic agent.
Claim 20
Dependent Claim
11 words
The method of claim 16 wherein the antineoplastic agent is doxorubicin.
Claim 21
Dependent Claim
11 words
The method of claim 16 wherein the antineoplastic agent is cisplatin.
Claim 22
Dependent Claim
11 words
The method of claim 16 wherein the antineoplastic agent is 5-fluorouracil
Claim 23
Dependent Claim
12 words
The method of claim 12 wherein the liposomes are stable plurilamellar vesicles.
Claim 24
Dependent Claim
10 words
The method of claim 12 wherein the liposomes comprise phosphatidylcholine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-31 | 1994-07-02 | 1995-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-31 | 1998-07-02 | 1999-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-31 | 2002-07-02 | 2003-01-01 | $7700.00 | Window Closed / Lapsed |