US4565696A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Production of immunogens by antigen conjugation to liposomes
Assignee: CALIFORNIA A CORP OF, University of, Regents of
•
Filing: 1983-08-03
•
Granted: 1986-01-21
•
Expires: 2003-08-03
Abstract
Abstract Enhanced immunogenicity is achieved by covalently linking immunogens to liposomes and injecting the membrane-bound-proteins into an appropriate vertebrate host. Methods and compositions are provided for producing antibodies.
Inventors
- 👤 Timothy D. Heath
- 👤 Pang Shek
- 👤 Demetrios Papahadjopoulos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:46
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K39/385; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K2039/555; A61K2039/55511; A61K2039/55555; A61K2039/60; A61K2039/6018; Y; Y10; Y10S; Y10S424/00; Y10S424/812; Y10S435/00; Y10S435/962; Y10S436/00; Y10S436/822; Y10S436/823; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
84 words
In a method for eliciting an immune response for the production of antibodies to a predetermined antigen, wherein an immunogen containing said predetermined antigen is administered to a vertebrate host resulting in the production of antibodies, the improvement which comprises employing as the immunogen, antigen covalently bound to the membrane of a liposome, said antigen being present in at least about 25 grams of antigen per mole of lipid, where said liposome internally contains an antibody enhancing effective amount of a cell growth inhibitor.
Claim 2
Dependent Claim
84 words
In a method for eliciting an immune response for the production of antibodies to a predetermined antigen, wherein an immunogen containing said predetermined antigen is administered to a vertebrate host resulting in the production of antibodies, the improvement which comprises employing as the immunogen, antigen covalently bound to the membrane of a liposome, said antigen being present in at least about 25 grams of antigen per mole of lipid, where said liposome internally contains an antibody enhancing effective amount of a cell growth inhibitor.
Claim 3
Dependent Claim
15 words
A method according to claim 1, wherein said cell growth inhibitor is an enzyme inhibitor.
Claim 4
Dependent Claim
12 words
A method according to claim 2, wherein said enzyme inhibitor is methotrexate.
References Cited (Backward Citations)
EP0036277A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-20 | 1989-07-22 | 1990-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-20 | 1993-07-22 | 1994-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-20 | 1997-07-22 | 1998-01-21 | $7700.00 | Window Closed / Lapsed |