US4973666A
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Peptide fragments containing HP and LP cross-links
Assignee: Washington Research Foundation
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Filing: 1987-11-06
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Granted: 1990-11-27
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Expires: 2007-11-06
Abstract
Abstract A method for assaying bone resorption rates by quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is also described.
Inventors
- 👤 David R. Eyre
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:29
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/02; C07K14/00; C07K14/435; C07K14/78; C07K16/00; C07K16/18; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6887; G01N2333/00; G01N2333/435; G01N2333/46; G01N2333/47; G01N2333/4701; G01N2333/4712; G01N2333/78; G01N2800/00; G01N2800/10; G01N2800/101; G01N2800/102; G01N2800/105; G01N2800/108; Y; Y10; Y10S; Y10S435/00; Y10S435/975; Y10S436/00; Y10S436/811; Y10S436/822; Y10S530/00; Y10S530/827; Y10S530/834
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
28 words
A purified peptide fragment consisting essentially of the amino acid sequence ##STR5## is hydroxylsyl pyridinoline or lysyl pyridinoline, and Gln is glutamine or wholly cyclized pyrrolidone carboxylic acid.
Claim 2
Dependent Claim
28 words
A purified peptide fragment consisting essentially of the amino acid sequence ##STR5## is hydroxylsyl pyridinoline or lysyl pyridinoline, and Gln is glutamine or wholly cyclized pyrrolidone carboxylic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-26 | 1994-05-28 | 1994-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-26 | 1998-05-28 | 1998-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-26 | 2002-05-28 | 2002-11-27 | $7700.00 | Window Closed / Lapsed |