US4973580A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Depolymerized dermatan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity and pharmaceutical compositions containing such
Assignee: OPOCRIN SpA LABORATORIO FARMACOBIOLOGICO
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Filing: 1989-05-10
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Granted: 1990-11-27
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Expires: 2009-05-10
Abstract
Abstract Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates, hyaluronic acid, by a radicalic reaction in an aqueous solution, at a temperature ranging between 20° and 70° C., in the presence of a catalyst selected in the group consisting of Cu++, Fe++, Cr+++, Cr 2 O 7 - as well as the resulting oligosaccharides and their related pharmaceutical compositions. The products exhibit high antithrombotic activity, little or no anticoagulant activity, high fibinolytic activity an antiinflammatory activity.
Inventors
- 👤 Giuseppe Mascellani
- 👤 Pietro Bianchini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:10
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; A; A61; A61P; A61P29/00; A61P7/00; A61P7/02; C08B37/0075; C08B37/0078
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
20 words
The oligosaccharide fraction from dermatan sulfate which has molecular weight 4800 daltons, U-aXa 2.5 U.I./mg. and UAPTT 1.3 U.I./mg, ##EQU3##
Claim 2
Dependent Claim
20 words
The oligosaccharide fraction from dermatan sulfate which has molecular weight 4800 daltons, U-aXa 2.5 U.I./mg. and UAPTT 1.3 U.I./mg, ##EQU3##
Claim 3
Dependent Claim
31 words
The oligosaccharide fraction from dermatan sulfate which has: a 6,000 D molecular weight, SO 3 - /COO - ratio 0.9÷1.2, AXa 1÷10 U/mg, and antithrombotic, thrombolytic, fibrinolytic, antiinfammatory activities in vivo.
Claim 4
Dependent Claim
31 words
The oligosaccharide fraction from dermatan sulfate which has: a 6,000 D molecular weight, SO 3 - /COO - ratio 0.9÷1.2, AXa 1÷10 U/mg, and antithrombotic, thrombolytic, fibrinolytic, antiinfammatory activities in vivo.
Claim 5
Dependent Claim
40 words
A pharmaceutical composition with an antithrombotic, antiinfammatory, fibrinolytic activity, comprising as the active ingredient, the oligosaccharide fraction according to claim 2, and pharmaceutically acceptable excipients, in the form of a sterile injectable solution or a suspension, capsule, tablet or syrup.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-26 | 1994-05-28 | 1994-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-26 | 1998-05-28 | 1998-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-26 | 2002-05-28 | 2002-11-27 | $7700.00 | Window Closed / Lapsed |