EP0101141A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
Assignee: Hepar Industries Inc
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Filing: 1983-01-12
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Granted: —
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Expires: 2003-01-12
Abstract
Abstract Process for manufacturing low molecular weight heparin fractions from normal heparin wherein such fractions have better pharmacological and therapeutic properties than the normal heparin. The process comprises the steps of, (a) acififying normal heparin to obtain heparinic acid with a pH in the range of about 3 to about 5, and (b) depolymerizing the heparinic acid by heating in the presence of an oxidizing agent to obtain low molecular weight heparin fractions in the range of about 4,000 Dalton to about 12,000 Dalton.
Inventors
- 👤 Milton R. Smith
- 👤 Eduardo Amaya
- 👤 Fernando Fussi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 19:34
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C08B37/0078; A; A61; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
70 words
Process for obtaining low molecular weight heparin fractions having elevated pharmacological properties comprising the steps of, (a) acidifying normal heparin to obtain heparinic acid with a pH in the range of from about 3 to about 5, and (b) depolymerizing said heparinic acid by heating in the presence of an oxidizing agent to obtain low molecular weight heparin fractions in the range of about 4,000 Dalton to about 12,000 Dalton.
Claim 2
Dependent Claim
70 words
Process for obtaining low molecular weight heparin fractions having elevated pharmacological properties comprising the steps of, (a) acidifying normal heparin to obtain heparinic acid with a pH in the range of from about 3 to about 5, and (b) depolymerizing said heparinic acid by heating in the presence of an oxidizing agent to obtain low molecular weight heparin fractions in the range of about 4,000 Dalton to about 12,000 Dalton.
Claim 3
Dependent Claim
20 words
Process of claim 1 wherein said pH of step (a) is in the range of about 3.0 to about 3.5.
Claim 4
Dependent Claim
12 words
Process of claim 1 wherein said depolymerizing takes place in an autoclave.
Claim 5
Dependent Claim
14 words
. Process of claim 1 wherein said acidifying is with a cation exchange resin.
Claim 6
Dependent Claim
18 words
Process of claim 1, wherein said oxidizing agent is selected from at least one of hydrogen peroxide. f
References Cited (Backward Citations)
No citation records indexed.
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