Patent US4967749A successfully refreshed from Google Patents.
US4967749A
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Hemodynamically responsive system for and method of treating a malfunctioning heart
Assignee: Medtronic Inc
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Filing: 1988-08-18
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Granted: 1990-11-06
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Expires: 2008-08-18
Abstract
Abstract A system for and method of treating a malfunctioning heart is based on hemodynamics, the pressure at a site in a patient's circulatory system being sensed. A signal is developed representative of short term mean arterial pressure (MAP), mean right atrial pressure (MRAP), mean right ventricle pressure (MRVP), mean left atrial pressure (MLAP), mean left ventrical pressure (MLVP) or mean central venous pressure (MCVP). A signal representative of fixed baseline pressure is provided and if the short term current mean pressure differs therefrom by a predetermined value, an indication of hemodynamic compromise, cardioversion/defibrillation is effected. In a second embodiment, the determination of whether the difference between fixed baseline pressure and mean current pressure is undertaken after a rate criteria (for example a heart rate above 155 b.p.m.) has been met. In a third embodiment, the rate and pressure criteria both must exist at the same time, before cardioverting/difibrillation is initiated. In a fourth embodiment, a microprocessor is used. The system may be integrated with antitachycardia and/or antibradycardia pacemakers.
Inventors
- 👤 Todd J. Cohen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:50
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/365; A61N1/36514; A61N1/36564; A61N1/38; A61N1/39; A61N1/3918; A61N1/3956; A61N1/3962; A61N1/39622
Claims Analysis
Total Claims: 58
Claim 1
Independent Claim
139 words
A system for treating a malfunctioning heart, the system including storage means for storing electrical energy, electrode means for electrically coupling the storage means to the heart, pressure responsive sensing means for sensing pressure at a site in a circulatory system, means for providing a first signal representative of fixed baseline pressure; means responsive to output from said sensing means for developing a second signal representing mean current pressure over a period of given length, and means responsive to output from the means for providing the first signal and output from the means for developing the second signal for charging and enabling discharge of the electrical energy stored by said storage means across said electrode means and into the heart upon change in the mean current pressure of at least a predetermined amount from the representative fixed baseline pressure.
Claim 2
Independent Claim
139 words
A system for treating a malfunctioning heart, the system including storage means for storing electrical energy, electrode means for electrically coupling the storage means to the heart, pressure responsive sensing means for sensing pressure at a site in a circulatory system, means for providing a first signal representative of fixed baseline pressure; means responsive to output from said sensing means for developing a second signal representing mean current pressure over a period of given length, and means responsive to output from the means for providing the first signal and output from the means for developing the second signal for charging and enabling discharge of the electrical energy stored by said storage means across said electrode means and into the heart upon change in the mean current pressure of at least a predetermined amount from the representative fixed baseline pressure.
Claim 3
Dependent Claim
51 words
The system of claim 1, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline right atrial pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing right atrial pressure.
Claim 4
Dependent Claim
58 words
The system of claim 2, including means responsive to the first signal and to the second signal for providing a control signal indicative of mean current right atrial pressure increasing by at least a predetermined amount from representative fixed baseline right atrial pressure, and wherein said means for charging and enabling discharge is responsive to the control signal.
Claim 5
Dependent Claim
51 words
The system of claim 1, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline right ventricular pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing right ventricular pressure.
Claim 6
Dependent Claim
57 words
The system of claim 4, including means responsive to the first signal and to the second signal for providing a control signal indicative of mean right ventricular pressure increasing by at least a predetermined amount from representative fixed baseline right ventricular pressure, and wherein said means for charging and enabling discharge is responsive to the control signal.
Claim 7
Dependent Claim
51 words
The system of claim 1, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline central venous pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing central venous pressure.
Claim 8
Dependent Claim
58 words
The system of claim 6, including means responsive to the first signal and to the second signal for providing a control output signal indicative of mean central venous pressure increasing by at least a predetermined amount from representative fixed baseline central venous pressure, and wherein said means for charging and enabling discharge is responsive to the control signal.
Claim 9
Dependent Claim
51 words
The system of claim 1, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline left atrial pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing left atrial pressure.
Claim 10
Dependent Claim
57 words
The system of claim 8, including means responsive to the first signal and to the second signal for providing a control signal indicative of mean left atrial pressure increasing by at least a predetermined amount from representative fixed baseline left atrial pressure, and wherein said means for charging and enabling discharge is responsive to the control signal.
Claim 11
Dependent Claim
51 words
The system of claim 1, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline left ventricular pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing left ventricular pressure.
Claim 12
Dependent Claim
57 words
The system of claim 10, including means responsive to the first signal and to the second signal for providing a control signal indicative of mean left ventricular pressure increasing by at least a predetermined amount from representative fixed baseline left ventricular pressure, and wherein said means for charging and enabling discharge is responsive to the control signal.
Claim 13
Dependent Claim
49 words
The system of claim 1, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline aterial pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing arterial pressure.
Claim 14
Dependent Claim
55 words
The system of claim 12, including means responsive to the first signal and to the second signal for providing a control signal indicative of representative fixed arterial pressure dropping by at least a predetermined amount from mean baseline arterial pressure, and wherein said means for charging and enabling discharge is responsive to the control signal.
Claim 15
Dependent Claim
31 words
The system of claim 1, including microprocessor means for developing a control signal to control the means for charging and enabling discharge of the electrical energy stored by the storage means.
Claim 16
Dependent Claim
64 words
The system of claim 1, including means responsive to the first signal and to the second signal for providing a control signal to control the means for charging and enabling discharge of the electrical energy stored by the storage means, the control signal being indicative of mean blood pressure at the site departing from representative fixed baseline pressure by at least a predetermined amount.
Claim 17
Independent Claim
229 words
A system for treating a malfunctioning heart, the system comprising electrical means for sensing heart rate and producing a first control signal upon the heart rate exceeding a predetermined rate; pressure responsive sensing means for sensing pressure at a site in a circulatory system, means for providing a first signal representative of fixed baseline pressure, means responsive to output from said sensing means for developing a pressure-related second signal representing mean current pressure at the site over a period of given length and for producing a second control signal indicative of the mean current pressure at the site departing from fixed baseline pressure by at least a predetermined amount; controllable antitachycardia pacemaking means for supplying pacing signals to the heart; controllable cardioverting/defibrillating means including storage means for storing electrical energy and electrode means for applying electrical energy from the storage means to the heart to cardiovert or to defibrillate same; control circuit means responsive to the first control signal and to the second control signal for enabling said antitachycardia pacemaking means in response to presence of the first control signal and contemporaneous absence of the second control signal and for enabling said cardioverting/defibrillating means in response to contemporaneous presence of both the first control signal and the second control signal; and means for discharging electrical energy stored by said storage means across said electrode means and into the heart.
Claim 18
Independent Claim
229 words
A system for treating a malfunctioning heart, the system comprising electrical means for sensing heart rate and producing a first control signal upon the heart rate exceeding a predetermined rate; pressure responsive sensing means for sensing pressure at a site in a circulatory system, means for providing a first signal representative of fixed baseline pressure, means responsive to output from said sensing means for developing a pressure-related second signal representing mean current pressure at the site over a period of given length and for producing a second control signal indicative of the mean current pressure at the site departing from fixed baseline pressure by at least a predetermined amount; controllable antitachycardia pacemaking means for supplying pacing signals to the heart; controllable cardioverting/defibrillating means including storage means for storing electrical energy and electrode means for applying electrical energy from the storage means to the heart to cardiovert or to defibrillate same; control circuit means responsive to the first control signal and to the second control signal for enabling said antitachycardia pacemaking means in response to presence of the first control signal and contemporaneous absence of the second control signal and for enabling said cardioverting/defibrillating means in response to contemporaneous presence of both the first control signal and the second control signal; and means for discharging electrical energy stored by said storage means across said electrode means and into the heart.
Claim 19
Dependent Claim
57 words
The system according to claim 16, including means responsive to output from said electrical means for sensing heart rate for developing a discharge-synchronizing signal synchronized to an R-wave, and wherein said means for discharging electrical energy across said electrode means and into the heart includes means for synchronizing the discharge with the discharge-synchronizing signal to effect cardioversion.
Claim 20
Dependent Claim
37 words
The system according to claim 17, wherein said means for discharging electrical energy across said electrode means and into the heart effects discharge on a nonsynchronized basis, in the absence of the synchronization signal, to effect defibrillation.
Claim 21
Dependent Claim
29 words
The system according to claim 16, wherein said means for discharging electrical energy across said electrodes and into the heart effects discharge on a nonsynchronized basis to effect defibrillation.
Claim 22
Dependent Claim
51 words
The system of claim 16, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline right atrial pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing right atrial pressure.
Claim 23
Dependent Claim
43 words
The system of claim 20, including means responsive to the first signal and to the pressure-related second signal for providing the second control signal indicative of mean right atrial pressure increasing by at least a predetermined amount from fixed baseline right atrial pressure.
Claim 24
Dependent Claim
51 words
The system of claim 16, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline right ventricular pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing right ventricular pressure.
Claim 25
Dependent Claim
43 words
The system of claim 22, including means responsive to the first signal and to the pressure-related second signal for providing the second control signal indicative of mean right ventricular pressure increasing by at least a predetermined amount from fixed baseline right ventricular pressure.
Claim 26
Dependent Claim
51 words
The system of claim 16, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline central venous pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing central venous pressure.
Claim 27
Dependent Claim
43 words
The system of claim 24, including means responsive to the first signal and to the pressure-related second signal for providing the second control output signal indicative of mean central venous pressure increasing at least a predetermined amount from fixed baseline central venous pressure.
Claim 28
Dependent Claim
51 words
The system of claim 16, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline left atrial pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing left atrial pressure.
Claim 29
Dependent Claim
43 words
The system of claim 26, including means responsive to the first signal and to the pressure-related second signal for providing the second control signal indicative of mean left atrial pressure increasing by at least a predetermined amount from fixed baseline left atrial pressure.
Claim 30
Dependent Claim
51 words
The system of claim 16, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline left ventricular pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing left ventricular pressure.
Claim 31
Dependent Claim
43 words
The system of claim 28, including means responsive to the first signal and to the pressure-related second signal for providing the second control signal indicative of mean left ventricular pressure increasing by at least a predetermined amount from fixed baseline left ventricular pressure.
Claim 32
Dependent Claim
49 words
The system of claim 16, wherein said means for providing a first signal comprises means for providing a first signal representative of fixed baseline arterial pressure, and wherein said pressure responsive sensing means for sensing pressure at a site in a circulatory system comprises means for sensing arterial pressure.
Claim 33
Dependent Claim
45 words
The system of claim 30, including means responsive to the first signal and to the pressure-related second signal for providing the second control signal indicative of mean arterial pressure reaching a predetermined level below fixed baseline arterial pressure, the second control signal indicating hemodynamic compromise.
Claim 34
Dependent Claim
77 words
In a method of treating a malfunctioning heart, the method including a step of sensing pressure at a site in a circulatory system, an improvement comprising providing a representation of fixed baseline pressure, determining mean current pressure from the sensed pressure at the site over a period of given length, and delivering cardioverting/defibrillating electrical energy to the heart in response to change of at least a predetermined magnitude in the mean current pressure from fixed baseline pressure.
Claim 35
Dependent Claim
77 words
In a method of treating a malfunctioning heart, the method including a step of sensing pressure at a site in a circulatory system, an improvement comprising providing a representation of fixed baseline pressure, determining mean current pressure from the sensed pressure at the site over a period of given length, and delivering cardioverting/defibrillating electrical energy to the heart in response to change of at least a predetermined magnitude in the mean current pressure from fixed baseline pressure.
Claim 36
Dependent Claim
65 words
The method of claim 32, wherein the step of sensing pressure at at a site in a circulatory system comprises sensing right atrial pressure, and the method includes sensing heart rate, said step of delivering cardioverting/defibrillating electrical energy being taken upon the heart rate exceeding a given rate and current mean right atrial pressure exceeding baseline right atrial pressure by at least the predetermined magnitude.
Claim 37
Dependent Claim
64 words
The method of claim 32, wherein the step of sensing pressure at a site in a circulatory system comprises sensing right ventricular pressure, and the method includes sensing heart rate, said step of delivering cardioverting/defibrillating electrical energy being taken upon the heart rate exceeding a given rate and current mean right ventricular pressure exceeding baseline right ventricle pressure by at least the predetermined magnitude.
Claim 38
Dependent Claim
65 words
The method of claim 32, wherein the step of sensing pressure at a site in a circulatory system comprises sensing central venous pressure, and the method includes sensing heart rate, said step of delivering cardioverting/defibrillating electrical energy being taken upon the heart rate exceeding a given rate and current mean central venous pressure exceeding fixed baseline central venous pressure by at least the predetermined magnitude.
Claim 39
Dependent Claim
65 words
The method of claim 32, wherein the step of sensing pressure at a site in a circulatory system comprises sensing left atrial pressure, and the method includes sensing heart rate, said step of delivering cardioverting/defibrillating electrical energy being taken upon the heart rate exceeding a given rate and current mean left atrial pressure exceeding fixed baseline left atrial pressure by at least the predetermined magnitude.
Claim 40
Dependent Claim
66 words
The method of claim 32, wherein the step of sensing pressure at a site in a circulatory system comprises sensing left ventricular pressure, and the method includes sensing heart rate, said step of delivering cardioverting/defibrillating electrical energy being taken upon the heart rate exceeding a given rate and the current mean left ventricular pressure exceeding fixed baseline left ventricular pressure by at least the predetermined magnitude.
Claim 41
Dependent Claim
67 words
The method of claim 32, wherein the step of sensing pressure at a site in a circulatory system comprises sensing arterial pressure, and the method includes sensing heart rate, said step of delivering cardioverting/defibrillating electrical energy being taken upon the heart rate exceeding a given rate and mean current arterial pressure departing from fixed baseline arterial pressure by at least the predetermined magnitude in a decreasing direction.
Claim 42
Dependent Claim
50 words
The method of claim 32, wherein the step of sensing pressure at a site in a circulatory system comprises sensing right atrial pressure, said step of delivering cardioverting/defibrillating electrical energy being taken upon mean current right atrial pressure exceeding fixed baseline right atrial pressure by at least the predetermined magnitude.
Claim 43
Dependent Claim
50 words
The method of claim 32, wherein the step of sensing pressure at a point in a circulatory system comprises sensing right ventricular pressure, said step of delivering cardioverting/defibrillating electrical energy being taken upon mean current right ventricular pressure exceeding fixed baseline right ventricular pressure by at least the predetermined magnitude.
Claim 44
Dependent Claim
50 words
The method of claim 32, wherein the step of sensing pressure at a point in a circulatory system comprises sensing central venous pressure, said step of delivering cardioverting/defibrillating electrical energy being taken upon mean current central venous pressure exceeding fixed baseline central venous pressure by at least the predetermined magnitude.
Claim 45
Dependent Claim
50 words
The method of claim 32, wherein the step of sensing pressure at a point in a circulatory system comprises sensing left atrial pressure, said step of delivering cardioverting/defibrillating electrical energy being taken upon mean current left atrial pressure exceeding fixed baseline left atrial pressure by at least the predetermined magnitude.
Claim 46
Dependent Claim
50 words
The method of claim 32, wherein the step of sensing pressure at a point in a circulatory system comprises sensing left ventricular pressure, said step of delivering cardioverting/defibrillating electrical energy being taken upon mean current left ventricular pressure exceeding fixed baseline left ventricular pressure by at least the predetermined magnitude.
Claim 47
Dependent Claim
51 words
The method of claim 32, wherein the step of sensing pressure at a point in a circulatory system comprises sensing arterial pressure, said step of cardioverting/defibrillating electrical energy being taken upon mean current arterial pressure departing from fixed baseline arterial pressure by at least the predetermined magnitude in a decreasing direction.
Claim 48
Independent Claim
108 words
A system for treating a malfunctioning heart, the system including means for providing cardioverting/defibrillating electrical energy, pressure responsive sensing means for sensing pressure at a site in a circulatory system, means for providing a fixed signal representative of fixed baseline pressure, means responsive to output from said pressure responsive sensing means for developing a further signal representing mean pressure over a period of given length, and means responsive to the fixed signal and to the further signal for delivering the cardioverting/defibrillating electrical energy into the heart upon occurrence of departure of the further signal from the fixed signal by at least a predetermined magnitude indicative of hemodynamic compromise.
Claim 49
Independent Claim
108 words
A system for treating a malfunctioning heart, the system including means for providing cardioverting/defibrillating electrical energy, pressure responsive sensing means for sensing pressure at a site in a circulatory system, means for providing a fixed signal representative of fixed baseline pressure, means responsive to output from said pressure responsive sensing means for developing a further signal representing mean pressure over a period of given length, and means responsive to the fixed signal and to the further signal for delivering the cardioverting/defibrillating electrical energy into the heart upon occurrence of departure of the further signal from the fixed signal by at least a predetermined magnitude indicative of hemodynamic compromise.
Claim 50
Independent Claim
186 words
A system for treating a malfunctioning heart, the system comprising electrical means for sensing heart rate and producing a first control signal whenever the rate exceeds a predetermined rate; pressure responsive means for sensing pressure at a site in a circulatory system; means for providing a fixed signal representative of fixed baseline pressure; means responsive to output from the pressure responsive means for developing a further signal representing mean pressure over a period of given length; means responsive to the first signal and to the further signal for developing a second control signal upon departure of the further signal from the first signal by at least a predetermined magnitude; controllable antitachycardia pacemaking means for supplying pacing signals to the heart; means for producing controllable cardioverting/defibrillating electrical energy; control circuit means responsive to the first control signal and to the second control signal for enabling said antitachycardia pacemaking means upon presence of the first control signal and absence of the second control signal and for enabling said means for producing the cardioverting/defibrillating electrical energy upon contemporaneous presence of the first control signal and the second control signal.
Claim 51
Independent Claim
186 words
A system for treating a malfunctioning heart, the system comprising electrical means for sensing heart rate and producing a first control signal whenever the rate exceeds a predetermined rate; pressure responsive means for sensing pressure at a site in a circulatory system; means for providing a fixed signal representative of fixed baseline pressure; means responsive to output from the pressure responsive means for developing a further signal representing mean pressure over a period of given length; means responsive to the first signal and to the further signal for developing a second control signal upon departure of the further signal from the first signal by at least a predetermined magnitude; controllable antitachycardia pacemaking means for supplying pacing signals to the heart; means for producing controllable cardioverting/defibrillating electrical energy; control circuit means responsive to the first control signal and to the second control signal for enabling said antitachycardia pacemaking means upon presence of the first control signal and absence of the second control signal and for enabling said means for producing the cardioverting/defibrillating electrical energy upon contemporaneous presence of the first control signal and the second control signal.
Claim 52
Dependent Claim
127 words
In a system for treating a malfunctioning heart of a patient, the system including means for delivering electrical energy to the heart and pressure responsive means for sensing pressure at a site in a circulatory system, an improvement comprising means for providing a first signal representative of fixed baseline pressure; means coupled to said pressure responsive means and responsive to output therefrom for producing a second signal representing mean pressure over a period of given length; means responsive to the first signal and to the second signal for producing a control signal upon occurrence of the second signal departing from the first signal by at least a given magnitude; and means responsive to the control signal for enabling the means for delivering electrical energy to the heart.
Claim 53
Dependent Claim
127 words
In a system for treating a malfunctioning heart of a patient, the system including means for delivering electrical energy to the heart and pressure responsive means for sensing pressure at a site in a circulatory system, an improvement comprising means for providing a first signal representative of fixed baseline pressure; means coupled to said pressure responsive means and responsive to output therefrom for producing a second signal representing mean pressure over a period of given length; means responsive to the first signal and to the second signal for producing a control signal upon occurrence of the second signal departing from the first signal by at least a given magnitude; and means responsive to the control signal for enabling the means for delivering electrical energy to the heart.
Claim 54
Independent Claim
137 words
A system for treating a malfunctioning heart of a patient, the system comprising pressure responsive means for sensing pressure at a site in a circulatory system; means for providing a first signal representing fixed baseline pressure; means coupled to said pressure responsive means and responsive to output therefrom for producing a second signal representing mean pressure over a period of given length; means responsive to the first signal and to the second signal for producing a first control signal upon occurrence of the second signal departing from the first signal by at least a given magnitude; means responsive to heart rate for producing a second control signal upon heart rate exceeding a given rate; and means responsive to at least the first control signal and to the second control signal for delivering electrical energy to the heart.
Claim 55
Independent Claim
137 words
A system for treating a malfunctioning heart of a patient, the system comprising pressure responsive means for sensing pressure at a site in a circulatory system; means for providing a first signal representing fixed baseline pressure; means coupled to said pressure responsive means and responsive to output therefrom for producing a second signal representing mean pressure over a period of given length; means responsive to the first signal and to the second signal for producing a first control signal upon occurrence of the second signal departing from the first signal by at least a given magnitude; means responsive to heart rate for producing a second control signal upon heart rate exceeding a given rate; and means responsive to at least the first control signal and to the second control signal for delivering electrical energy to the heart.
Claim 56
Dependent Claim
83 words
In a method of treating a malfunctioning heart of a patient which includes sensing change in pressure at a site in a circulatory system and delivering to the patient electrical energy, an improvement comprising providing a representation of fixed baseline pressure, determining mean current pressure from the sensed pressure over a period of given length, and wherein the step of delivering electrical energy is taken in response to a difference of at least predetermined magnitude between mean current pressure and fixed baseline pressure.
Claim 57
Dependent Claim
83 words
In a method of treating a malfunctioning heart of a patient which includes sensing change in pressure at a site in a circulatory system and delivering to the patient electrical energy, an improvement comprising providing a representation of fixed baseline pressure, determining mean current pressure from the sensed pressure over a period of given length, and wherein the step of delivering electrical energy is taken in response to a difference of at least predetermined magnitude between mean current pressure and fixed baseline pressure.
Claim 58
Dependent Claim
43 words
The method of claim 51, including determining heart rate, the step of delivering to the heart electrical energy being taken only upon the heart rate exceeding a given rate and the at least predetermined magnitude between mean current pressure and baseline pressure prevails.
References Cited (Backward Citations)
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| 7.5 Years (Year 8) | 1997-11-05 | 1998-05-07 | 1998-11-06 | $3760.00 | Window Closed / Lapsed |
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