US4963344A
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Method to enhance NMR imaging using chelated paramagnetic ions
Assignee: Bayer Pharma AG
•
Filing: 1989-06-23
•
Granted: 1990-10-16
•
Expires: 2009-06-23
Abstract
Abstract Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid.
Inventors
- 👤 Heinz Gries
- 👤 Douwe Rosenberg
- 👤 Hanns-Joachim Weinmann
- 👤 Ulrich Speck
- 👤 Wolfgang Mutzel
- 👤 Georg-Alexander Hayden
- 👤 Heinrich Pfeiffer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:24
CPC Classifications
C; C07; C07C; C07C323/00; C07C323/23; C07C323/24; C07C323/25; A; A61; A61K; A61K49/00; A61K49/04; A61K49/06; A61K49/08; A61K49/085; A61K49/10; A61K49/101; A61K49/103; A61K49/105; A61K49/106; A61K49/108; A61K49/14; A61K49/143; A61K49/16; A61K49/18; A61K49/1806; A61K49/1809; A61K49/1812; C07D; C07D257/00; C07D257/02; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808; C07F9/3817; C07F9/3839; C07F9/386; G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 178
Claim 1
Independent Claim
86 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissue undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible chelate complex of an ion of a lanthanide element of atomic numbers 58-70; and a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
86 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissue undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible chelate complex of an ion of a lanthanide element of atomic numbers 58-70; and a pharmaceutically acceptable carrier.
Claim 3
Independent Claim
109 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible chelate complex of an ion and, as a ligand, an acyclic or cyclic complexing agent containing organic nitrogen, phosphorus, oxygen or sulfur, the complexed ion being an ion of a lanthanide element of atomic numbers 58-70; and a pharmaceutically acceptable carrier.
Claim 4
Independent Claim
109 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible chelate complex of an ion and, as a ligand, an acyclic or cyclic complexing agent containing organic nitrogen, phosphorus, oxygen or sulfur, the complexed ion being an ion of a lanthanide element of atomic numbers 58-70; and a pharmaceutically acceptable carrier.
Claim 5
Independent Claim
32 words
A method of enhancing NMR imageability of a patient comprising administering to the patient an amount, effective to enhance NMR image contrast, of a physiologically compatible chelate complex of a paramagnetic ion.
Claim 6
Independent Claim
32 words
A method of enhancing NMR imageability of a patient comprising administering to the patient an amount, effective to enhance NMR image contrast, of a physiologically compatible chelate complex of a paramagnetic ion.
Claim 7
Independent Claim
46 words
A method of enhancing NMR imageability of a patient comprising administering to the patient an amount, effective to enhance NMR image contrast, of a physiologically compatible chelate complex of a paramagnetic ion having as a ligand a complexing agent containing organic nitrogen, phosphorous, oxygen or sulfur.
Claim 8
Independent Claim
46 words
A method of enhancing NMR imageability of a patient comprising administering to the patient an amount, effective to enhance NMR image contrast, of a physiologically compatible chelate complex of a paramagnetic ion having as a ligand a complexing agent containing organic nitrogen, phosphorous, oxygen or sulfur.
Claim 9
Dependent Claim
16 words
A method of claim 3, wherein the complex is formulated together with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
16 words
A method of claim 4, wherein the complex is formulated together with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
15 words
A method of claim 5, wherein said ion is an element of atomic numbers 58-70.
Claim 12
Dependent Claim
15 words
A method of claim 6, wherein said ion is an element of atomic numbers 58-70.
Claim 13
Dependent Claim
18 words
A method of claim 5, wherein said ion is an element of atomic numbers 21-29, 42 or 44.
Claim 14
Dependent Claim
18 words
A method of claim 6, wherein said ion is an element of atomic numbers 21-29, 42 or 44.
Claim 15
Independent Claim
44 words
A method of conducting NMR imaging, comprising NMR imaging a patient to whom there has been administered an amount effective to enhance NMR image contrast of a physiologically compatible chelate complex of a paramagnetic ion, whereby an NMR image of enhanced contrast is obtained.
Claim 16
Independent Claim
44 words
A method of conducting NMR imaging, comprising NMR imaging a patient to whom there has been administered an amount effective to enhance NMR image contrast of a physiologically compatible chelate complex of a paramagnetic ion, whereby an NMR image of enhanced contrast is obtained.
Claim 17
Independent Claim
57 words
A method of conducting NMR imaging, comprising NMR imaging a patient to whom there has been administered an amount effective to enhance NMR image contrast of a physiologically compatible chelate complex of a paramagnetic ion having as ligand a complexing agent containing organic nitrogen, phosphorous, oxygen or sulfur, whereby an NMR image of enhanced contrast is obtained.
Claim 18
Independent Claim
57 words
A method of conducting NMR imaging, comprising NMR imaging a patient to whom there has been administered an amount effective to enhance NMR image contrast of a physiologically compatible chelate complex of a paramagnetic ion having as ligand a complexing agent containing organic nitrogen, phosphorous, oxygen or sulfur, whereby an NMR image of enhanced contrast is obtained.
Claim 19
Dependent Claim
16 words
A method of claim 11, wherein the complex is formulated together with a pharmaceutically acceptable carrier.
Claim 20
Dependent Claim
16 words
A method of claim 12, wherein the complex is formulated together with a pharmaceutically acceptable carrier.
Claim 21
Dependent Claim
15 words
A method of claim 13, wherein said ion is an element of atomic numbers 58-70.
Claim 22
Dependent Claim
15 words
A method of claim 14, wherein said ion is an element of atomic numbers 58-70.
Claim 23
Dependent Claim
18 words
A method of claim 13, wherein said ion is an element of atomic numbers 21-29, 42 or 44.
Claim 24
Dependent Claim
18 words
A method of claim 14, wherein said ion is an element of atomic numbers 21-29, 42 or 44.
Claim 25
Dependent Claim
11 words
A method of claim 1, wherein the paramagnetic ion is Gd(III).
Claim 26
Dependent Claim
11 words
A method of claim 2, wherein the paramagnetic ion is Gd(III).
Claim 27
Dependent Claim
11 words
A method of claim 5, wherein the paramagnetic ion is Gd(III).
Claim 28
Dependent Claim
11 words
A method of claim 6, wherein the paramagnetic ion is Gd(III).
Claim 29
Dependent Claim
11 words
A method of claim 13, wherein the paramagnetic ion is Gd(III).
Claim 30
Dependent Claim
11 words
A method of claim 14, wherein the paramagnetic ion is Gd(III).
Claim 31
Dependent Claim
11 words
A method of claim 5, wherein the paramagnetic ion is Mn(II).
Claim 32
Dependent Claim
11 words
A method of claim 6, wherein the paramagnetic ion is Mn(II).
Claim 33
Dependent Claim
11 words
A method of claim 13, wherein the paramagnetic ion is Mn(II).
Claim 34
Dependent Claim
11 words
A method of claim 14, wherein the paramagnetic ion is Mn(II).
Claim 35
Dependent Claim
11 words
A method of claim 5, wherein the paramagnetic ion is iron.
Claim 36
Dependent Claim
11 words
A method of claim 6, wherein the paramagnetic ion is iron.
Claim 37
Dependent Claim
11 words
A method of claim 13, wherein the paramagnetic ion is iron.
Claim 38
Dependent Claim
11 words
A method of claim 14, wherein the paramagnetic ion is iron.
Claim 39
Dependent Claim
15 words
A method of claim 1, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 40
Dependent Claim
15 words
A method of claim 2, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 41
Dependent Claim
15 words
A method of claim 5, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 42
Dependent Claim
15 words
A method of claim 6, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 43
Dependent Claim
15 words
A method of claim 13, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 44
Dependent Claim
15 words
A method of claim 14, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 45
Dependent Claim
19 words
A method of claim 1, wherein no free acid or free base groups are present in the chelate complex.
Claim 46
Dependent Claim
19 words
A method of claim 2, wherein no free acid or free base groups are present in the chelate complex.
Claim 47
Dependent Claim
19 words
A method of claim 5, wherein no free acid or free base groups are present in the chelate complex.
Claim 48
Dependent Claim
19 words
A method of claim 6, wherein no free acid or free base groups are present in the chelate complex.
Claim 49
Dependent Claim
19 words
A method of claim 13, wherein no free acid or free base groups are present in the chelate complex.
Claim 50
Dependent Claim
19 words
A method of claim 14, wherein no free acid or free base groups are present in the chelate complex.
Claim 51
Dependent Claim
20 words
A method of claim 1, wherein a free acid or a free base group is present in the chelate complex.
Claim 52
Dependent Claim
20 words
A method of claim 2, wherein a free acid or a free base group is present in the chelate complex.
Claim 53
Dependent Claim
20 words
A method of claim 5, wherein a free acid or a free base group is present in the chelate complex.
Claim 54
Dependent Claim
20 words
A method of claim 6, wherein a free acid or a free base group is present in the chelate complex.
Claim 55
Dependent Claim
20 words
A method of claim 13, wherein a free acid or a free base group is present in the chelate complex.
Claim 56
Dependent Claim
20 words
A method of claim 14, wherein a free acid or a free base group is present in the chelate complex.
Claim 57
Dependent Claim
34 words
A method of claim 1, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 58
Dependent Claim
34 words
A method of claim 2, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 59
Dependent Claim
34 words
A method of claim 5, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 60
Dependent Claim
34 words
A method of claim 6, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 61
Dependent Claim
34 words
A method of claim 13, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 62
Dependent Claim
34 words
A method of claim 14, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 63
Dependent Claim
16 words
A method of claim 1, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 64
Dependent Claim
16 words
A method of claim 1, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 65
Dependent Claim
16 words
A method of claim 5, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 66
Dependent Claim
16 words
A method of claim 6, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 67
Dependent Claim
16 words
A method of claim 13, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 68
Dependent Claim
16 words
A method of claim 14, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 69
Dependent Claim
16 words
A method of claim 1, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 70
Dependent Claim
16 words
A method of claim 2, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 71
Dependent Claim
16 words
A method of claim 5, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 72
Dependent Claim
16 words
A method of claim 6, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 73
Dependent Claim
16 words
A method of claim 13, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 74
Dependent Claim
16 words
A method of claim 14, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 75
Dependent Claim
35 words
A method of claim 1, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 76
Dependent Claim
35 words
A method of claim 2, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 77
Dependent Claim
35 words
A method of claim 5, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 78
Dependent Claim
35 words
A method of claim 6, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 79
Dependent Claim
35 words
A method of claim 13, wherein said chelate comlex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 80
Dependent Claim
35 words
A method of claim 14, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 81
Dependent Claim
36 words
A method of claim 1, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 82
Dependent Claim
36 words
A method of claim 2, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 83
Dependent Claim
36 words
A method of claim 5, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 84
Dependent Claim
36 words
A method of claim 6, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 85
Dependent Claim
36 words
A method of claim 13, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 86
Dependent Claim
36 words
A method of claim 14, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 87
Dependent Claim
34 words
A method of claim 1, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 88
Dependent Claim
34 words
A method of claim 2, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 89
Dependent Claim
34 words
A method of claim 5, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 90
Dependent Claim
34 words
A method of claim 6, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 91
Dependent Claim
34 words
A method of claim 13, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 92
Dependent Claim
34 words
A method of claim 14, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 93
Dependent Claim
15 words
A method of claim 1, wherein the chelate complex is not bound to a protein.
Claim 94
Dependent Claim
15 words
A method of claim 2, wherein the chelate complex is not bound to a protein.
Claim 95
Dependent Claim
15 words
A method of claim 5, wherein the chelate complex is not bound to a protein.
Claim 96
Dependent Claim
15 words
A method of claim 6, wherein the chelate complex is not bound to a protein.
Claim 97
Dependent Claim
15 words
A method of claim 13, wherein the chelate complex is not bound to a protein.
Claim 98
Dependent Claim
15 words
A method of claim 14, wherein the chelate complex is not bound to a protein.
Claim 99
Dependent Claim
11 words
A method of claim 29, wherein the paramagnetic ion is Fe(II).
Claim 100
Dependent Claim
11 words
A method of claim 30, wherein the paramagnetic ion is Fe(II).
Claim 101
Dependent Claim
11 words
A method of claim 31, wherein the paramagnetic ion is Fe(II).
Claim 102
Dependent Claim
11 words
A method of claim 32, wherein the paramagnetic ion is Fe(II).
Claim 103
Independent Claim
89 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissue undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible chelate complex of an ion of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier.
Claim 104
Independent Claim
89 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissue undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible chelate complex of an ion of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier.
Claim 105
Independent Claim
112 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic physiologically compatible chelate complex of an ion and, as a ligand, an acyclic or cyclic complexing agent containing organic nitrogen, phosphorus, oxygen or sulfur, the complexed ion being an ion of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier.
Claim 106
Independent Claim
112 words
A method of imaging body tissue in a patient, comprising subjecting the patient to NMR tomography and prior to performing the NMR tomography administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic physiologically compatible chelate complex of an ion and, as a ligand, an acyclic or cyclic complexing agent containing organic nitrogen, phosphorus, oxygen or sulfur, the complexed ion being an ion of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier.
Claim 107
Dependent Claim
11 words
A method of claim 97, wherein the paramagnetic ion is Mn(II).
Claim 108
Dependent Claim
11 words
A method of claim 98, wherein the paramagnetic ion is Mn(II).
Claim 109
Dependent Claim
11 words
A method of claim 97, wherein the paramagnetic ion is iron.
Claim 110
Dependent Claim
11 words
A method of claim 98, wherein the paramagnetic ion is iron.
Claim 111
Dependent Claim
15 words
A method of claim 97, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 112
Dependent Claim
15 words
A method of claim 98, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 113
Dependent Claim
19 words
A method of claim 97, wherein no free acid or free base groups are present in the chelate complex.
Claim 114
Dependent Claim
19 words
A method of claim 98, wherein no free acid or free base groups are present in the chelate complex.
Claim 115
Dependent Claim
20 words
A method of claim 97, wherein a free acid or a free base group is present in the chelate complex.
Claim 116
Dependent Claim
20 words
A method of claim 98, wherein a free acid or a free base group is present in the chelate complex.
Claim 117
Dependent Claim
34 words
A method of claim 97, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 118
Dependent Claim
34 words
A method of claim 98, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 119
Dependent Claim
16 words
A method of claim 97, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 120
Dependent Claim
16 words
A method of claim 98, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 121
Dependent Claim
16 words
A method of claim 97, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 122
Dependent Claim
16 words
A method of claim 98, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 123
Dependent Claim
35 words
A method of claim 97, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 124
Dependent Claim
35 words
A method of claim 98, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 125
Dependent Claim
36 words
A method of claim 97, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 126
Dependent Claim
36 words
A method of claim 98, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 127
Dependent Claim
34 words
A method of claim 97, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 128
Dependent Claim
34 words
A method of claim 98, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 129
Dependent Claim
15 words
A method of claim 97, wherein the chelate complex is not bound to a protein.
Claim 130
Dependent Claim
15 words
A method of claim 98, wherein the chelate complex is not bound to a protein.
Claim 131
Dependent Claim
11 words
A method of claim 101, wherein the paramagnetic ion is Fe(II).
Claim 132
Dependent Claim
11 words
A method of claim 102, wherein the paramagnetic ion is Fe(II).
Claim 133
Dependent Claim
11 words
A method of claim 1, wherein the patient is a human.
Claim 134
Dependent Claim
11 words
A method of claim 2, wherein the patient is a human.
Claim 135
Dependent Claim
11 words
A method of claim 5, wherein the patient is a human.
Claim 136
Dependent Claim
11 words
A method of claim 6, wherein the patient is a human.
Claim 137
Dependent Claim
11 words
A method of claim 13, wherein the patient is a human.
Claim 138
Dependent Claim
11 words
A method of claim 14, wherein the patient is a human.
Claim 139
Dependent Claim
11 words
A method of claim 97, wherein the patient is a human.
Claim 140
Dependent Claim
11 words
A method of claim 98, wherein the patient is a human.
Claim 141
Independent Claim
42 words
A method of enhancing an NMR image, comprising obtaining an enhanced NMR image by NMR imaging a human to whom there has been administered an amount, effective to enhance NMR image contrast, of a physiologically compatible chelate complex of a paramagnetic ion.
Claim 142
Independent Claim
42 words
A method of enhancing an NMR image, comprising obtaining an enhanced NMR image by NMR imaging a human to whom there has been administered an amount, effective to enhance NMR image contrast, of a physiologically compatible chelate complex of a paramagnetic ion.
Claim 143
Dependent Claim
16 words
A method of claim 133, wherein the complex is formulated together with a pharmaceutically acceptable carrier.
Claim 144
Dependent Claim
15 words
A method of claim 134, wherein said ion is an element of atomic numbers 58-70.
Claim 145
Dependent Claim
18 words
A method of claim 134, wherein said ion is an element of atomic numbers 21-29, 42 or 44.
Claim 146
Dependent Claim
11 words
A method of claim 134, wherein the paramagnetic ion is Gd(III).
Claim 147
Dependent Claim
11 words
A method of claim 134, wherein the paramagnetic ion is Mn(II).
Claim 148
Dependent Claim
11 words
A method of claim 134, wherein the paramagnetic ion is iron.
Claim 149
Dependent Claim
11 words
A method of claim 134, wherein the paramagentic ion is Fe(II).
Claim 150
Dependent Claim
15 words
A method of claim 134, wherein the paramagnetic ion is chelated by an aminopolycarboxylic acid.
Claim 151
Dependent Claim
19 words
A method of claim 134, wherein no free acid or free base groups are present in the chelate complex.
Claim 152
Dependent Claim
20 words
A method of claim 134, wherein a free acid or a free base group is present in the chelate complex.
Claim 153
Dependent Claim
34 words
A method of claim 134, wherein a free acid or a free base group of the chelate complex is in the form of a salt thereof with an inorganic or organic base or acid.
Claim 154
Dependent Claim
16 words
A method of claim 134, wherein the paramagnetic ion is chelated by an open-chain chelating agent.
Claim 155
Dependent Claim
16 words
A method of claim 134, wherein the paramagnetic ion is chelated by a cyclic chelating agent.
Claim 156
Dependent Claim
35 words
A method of claim 134, wherein said chelate complex is both a salt of said paramagnetic ion and the chelate complexing agent thereof, and also a salt with an inorganic or organic base or acid.
Claim 157
Dependent Claim
36 words
A method of claim 134, wherein said chelate complex is only a salt of said paramagnetic ion and the chelate complexing agent thereof and not also a salt with an inorganic or organic base or acid.
Claim 158
Dependent Claim
34 words
A method of claim 134, wherein the chelate complex molecule consists of a single paramagnetic ion chelated by a chelating agent which optionally is a salt with an inorganic or organic base or acid.
Claim 159
Dependent Claim
15 words
A method of claim 134, wherein the chelate complex is not bound to a protein.
Claim 160
Dependent Claim
11 words
A method of claim 1, wherein the chelate complex is nonionic.
Claim 161
Dependent Claim
11 words
A method of claim 2, wherein the chelate complex is nonionic.
Claim 162
Dependent Claim
11 words
A method of claim 5, wherein the chelate complex is nonionic.
Claim 163
Dependent Claim
11 words
A method of claim 6, wherein the chelate complex is nonionic.
Claim 164
Dependent Claim
11 words
A method of claim 13, wherein the chelate complex is nonionic.
Claim 165
Dependent Claim
11 words
A method of claim 14, wherein the chelate complex is nonionic.
Claim 166
Dependent Claim
11 words
A method of claim 23, wherein the chelate complex is nonionic.
Claim 167
Dependent Claim
11 words
A method of claim 27, wherein the chelate complex is nonionic.
Claim 168
Dependent Claim
11 words
A method of claim 31, wherein the chelate complex is nonionic.
Claim 169
Dependent Claim
11 words
A method of claim 61, wherein the chelate complex is nonionic.
Claim 170
Dependent Claim
11 words
A method of claim 67, wherein the chelate complex is nonionic.
Claim 171
Dependent Claim
11 words
A method of claim 97, wherein the chelate complex is nonionic.
Claim 172
Dependent Claim
11 words
A method of claim 98, wherein the chelate complex is nonionic.
Claim 173
Dependent Claim
11 words
A method of claim 133, wherein the chelate complex is nonionic.
Claim 174
Dependent Claim
11 words
A method of claim 137, wherein the chelate complex is nonionic.
Claim 175
Dependent Claim
11 words
A method of claim 138, wherein the chelate complex is nonionic.
Claim 176
Dependent Claim
11 words
A method of claim 139, wherein the chelate complex is nonionic.
Claim 177
Dependent Claim
11 words
A method of claim 145, wherein the chelate complex is nonionic.
Claim 178
Dependent Claim
11 words
A method of claim 146, wherein the chelate complex is nonionic.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-15 | 1994-04-16 | 1994-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-15 | 1998-04-16 | 1998-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-15 | 2002-04-16 | 2002-10-16 | $7700.00 | Window Closed / Lapsed |